What is antiphospholipid syndrome? View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-12

AUTHORS

Doruk Erkan, Michael D. Lockshin

ABSTRACT

The description of antiphospholipid syndrome (APS) is vascular thrombosis and/or pregnancy morbidity occurring in persons with antiphospholipid antibodies (aPL). However, because of an unclear etiopathogenesis and the heterogeneous nature of aPL and of aPL-related clinical manifestations, a single, unambiguous definition of APS does not exist. In this paper, we describe a structured approach to APS, discuss the controversies, and offer descriptions of APS that include: an autoimmune systemic disease with a spectrum of (mostly thrombotic) clinical manifestations, an overdiagnosed disease when aPL is present but has no proven direct causative role in the clinical manifestations, and a disease of controversies that requires clarification of etiology and mechanisms and riskstratified controlled clinical studies. More... »

PAGES

451-457

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11926-004-0024-1

DOI

http://dx.doi.org/10.1007/s11926-004-0024-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051365266

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15527704


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