The future of vaccines in the management of addictive disorders View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-10

AUTHORS

Frank M. Orson, Berma M. Kinsey, Rana A. K. Singh, Yan Wu, Tracie Gardner, Thomas R. Kosten

ABSTRACT

Conventional substance abuse treatments have had only limited success. As a result, new approaches, including vaccination to block the effects of drugs such as cocaine, nicotine, methamphetamine, and phencyclidine, are in development. Although a number of possible rationales for the effects of antidrug vaccines have been suggested, the most straightforward and intuitive mechanism would involve binding of the drug by antibodies in the bloodstream, thereby blocking entry or reducing the rate of entry of the drug into the central nervous system. The theoretical parameters that would influence vaccine-induced drug pharmacodynamics are presented in this review, along with the current status on vaccine development for nicotine, cocaine, methamphetamine, and phencyclidine. More... »

PAGES

381-387

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11920-007-0049-z

DOI

http://dx.doi.org/10.1007/s11920-007-0049-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013109203

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17915077


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