Cannabinoids for Neuropathic Pain View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-10

AUTHORS

Perry G. Fine, Mark J. Rosenfeld

ABSTRACT

Treatment options for neuropathic pain have limited efficacy and use is fraught with dose-limiting adverse effects. The endocannabinoid system has been elucidated over the last several years, demonstrating a significant interface with pain homeostasis. Exogenous cannabinoids have been demonstrated to be effective in a range of experimental neuropathic pain models, and there is mounting evidence for therapeutic use in human neuropathic pain conditions. This article reviews the history, pharmacologic development, clinical trials results, and the future potential of nonsmoked, orally bioavailable, nonpsychoactive cannabinoids in the management of neuropathic pain. More... »

PAGES

451

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11916-014-0451-2

DOI

http://dx.doi.org/10.1007/s11916-014-0451-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022415827

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25160710


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