Exploiting the WNT Signaling Pathway for Clinical Purposes View Full Text


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Article Info

DATE

2017-04-21

AUTHORS

Mark L. Johnson, Robert R. Recker

ABSTRACT

Purpose of ReviewThe goal of this paper is to evaluate critically the literature published over the past 3 years regarding the Wnt signaling pathway. The Wnt pathway was found to be involved in bone biology in 2001–2002 with the discovery of a (G171V) mutation in the lipoprotein receptor-related protein 5 (LRP5) that resulted in high bone mass and another mutation that completely inactivated Lrp5 function and resulted in osteoporosis pseudoglioma syndrome (OPPG). The molecular biology has been complex, and very interesting. It has provided many opportunities for exploitation to develop new clinical treatments, particularly for osteoporosis. More clinical possibilities include: treatments for fracture healing, corticosteroid osteoporosis, osteogenesis imperfecta, and others. In addition, we wish to provide historical information coming from distant publications (~350 years ago) regarding bone biology that have been confirmed by study of Wnt signaling.Recent FindingsA recent finding is the development of an antibody to sclerostin that is under study as a treatment for osteoporosis.SummaryDevelopment of treatments for other forms of osteoporosis, such as corticosteroid osteoporosis, is also underway. The full range of the applications of the work is not yet been achieved. More... »

PAGES

153-161

References to SciGraph publications

  • 2013-06-11. Involvement of WNT/β-catenin Signaling in the Treatment of Osteoporosis in CALCIFIED TISSUE INTERNATIONAL
  • 2000-09. arrow encodes an LDL-receptor-related protein essential for Wingless signalling in NATURE
  • 2013-09-04. Estrogen receptors/' roles in the control of mechanically adaptive bone (re)modeling in BONEKEY REPORTS
  • 1993-02. Osteocytes, strain detection, bone modeling and remodeling in CALCIFIED TISSUE INTERNATIONAL
  • 1986. The Law of Bone Remodelling in NONE
  • 2013-01-29. Serum extracellular secreted antagonists of the canonical Wnt/β-catenin signaling pathway in patients with Cushing’s syndrome in OSTEOPOROSIS INTERNATIONAL
  • 2011-05-15. Mechanical loading-related changes in osteocyte sclerostin expression in mice are more closely associated with the subsequent osteogenic response than the peak strains engendered in OSTEOPOROSIS INTERNATIONAL
  • 2014-01-30. Developments in Sclerostin Biology: Regulation of Gene Expression, Mechanisms of Action, and Physiological Functions in CURRENT OSTEOPOROSIS REPORTS
  • 2011-06-10. Long-term treatment with raloxifene, but not bisphosphonates, reduces circulating sclerostin levels in postmenopausal women in OSTEOPOROSIS INTERNATIONAL
  • 1998-01. Perspectives: Some Roles of Mechanical Usage, Muscle Strength, and the Mechanostat in Skeletal Physiology, Disease, and Research in CALCIFIED TISSUE INTERNATIONAL
  • 2013-02-06. WNT signaling in bone homeostasis and disease: from human mutations to treatments in NATURE MEDICINE
  • 2016-07-25. Wnt5a mediated canonical Wnt signaling pathway activation in orthodontic tooth movement: possible role in the tension force-induced bone formation in JOURNAL OF MOLECULAR HISTOLOGY
  • 2016-04-26. TGF-β and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease in BONE RESEARCH
  • 2012-01-10. LRP5 and bone mass regulation: Where are we now? in BONEKEY REPORTS
  • 2006-06-21. Bone Biomechanical Properties in EP4 Knockout Mice in CALCIFIED TISSUE INTERNATIONAL
  • 2015-06-07. LRP receptor family member associated bone disease in REVIEWS IN ENDOCRINE AND METABOLIC DISORDERS
  • 2000-09. An LDL-receptor-related protein mediates Wnt signalling in mice in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11914-017-0357-0

    DOI

    http://dx.doi.org/10.1007/s11914-017-0357-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1084992277

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28432596


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