Vibrational Spectroscopic Imaging for the Evaluation of Matrix and Mineral Chemistry View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-09-21

AUTHORS

S. Gamsjaeger, R. Mendelsohn, A. L. Boskey, S. Gourion-Arsiquaud, K. Klaushofer, E. P. Paschalis

ABSTRACT

Metabolic bone diseases manifesting fragility fractures (such as osteoporosis) are routinely diagnosed based on bone mineral density (BMD) measurements, and the effect of various therapies also evaluated based on the same outcome. Although useful, it is well recognized that this metric does not fully account for either fracture incidence or the effect of various therapies on fracture incidence, thus, the emergence of bone quality as a contributing factor in the determination of bone strength. Infrared and Raman vibrational spectroscopic techniques are particularly well-suited for the determination of bone quality as they provide quantitative and qualitative information of the mineral and organic matrix bone components, simultaneously. Through the use of microspectroscopic techniques, this information is available in a spatially resolved manner, thus, the outcomes may be easily correlated with outcomes from techniques such as histology, histomorphometry, and nanoindentation, linking metabolic status with material properties. More... »

PAGES

454-464

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11914-014-0238-8

    DOI

    http://dx.doi.org/10.1007/s11914-014-0238-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1041212222

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25240579


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