Atypical Femoral Fractures, Bisphosphonates, and Mechanical Stress View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-06

AUTHORS

Per Aspenberg, Jörg Schilcher

ABSTRACT

Atypical fractures are stress fractures occurring in the femoral shaft and closely related to bisphosphonate use. We here discuss their radiographic definition and different putative etiologies, apart from mechanical stress. Long time reduction of skeletal remodeling because of bisphosphonate use is thought to allow time for the bone to deteriorate mechanically, resulting in reduced toughness. However, the risk of atypical fracture diminishes rapidly after cessation of treatment, which suggests more acute effects of bisphosphonate use. Microdamage normally accumulates at areas of high stress. Possibly, ongoing bisphosphonate use reduces the ability to resorb and replace areas of microdamage by targeted remodeling. This could lead to crack propagation beyond a point of no return, ending in macroscopic stress fracture. More... »

PAGES

189-193

References to SciGraph publications

  • 1989-11. Transient-steady state phenomena in microdamage physiology: A proposed algorithm for lamellar bone in CALCIFIED TISSUE INTERNATIONAL
  • 2012-01. The Effect of Long-term Alendronate Treatment on Cortical Thickness of the Proximal Femur in CLINICAL ORTHOPAEDICS AND RELATED RESEARCH®
  • 2012-12. Atypical fractures do not have a thicker cortex in OSTEOPOROSIS INTERNATIONAL
  • 2012-09. Low-energy diaphyseal femoral fractures associated with bisphosphonate use and severe curved femur: a case series in JOURNAL OF BONE AND MINERAL METABOLISM
  • 2012-12. Comment on Compston: Pathophysiology of atypical femoral fractures and osteonecrosis of the jaw in OSTEOPOROSIS INTERNATIONAL
  • 2007-09. Bilateral femoral insuffiency fractures treated with inflatable intramedullary nails: a case report in ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
  • 2009-08. Association of low-energy femoral fractures with prolonged bisphosphonate use: a case control study in OSTEOPOROSIS INTERNATIONAL
  • 2008-09. Collagen maturity, glycation induced-pentosidine, and mineralization are increased following 3-year treatment with incadronate in dogs in OSTEOPOROSIS INTERNATIONAL
  • 2009-07. Women and men with hip fractures have a longer femoral neck moment arm and greater impact load in a sideways fall in OSTEOPOROSIS INTERNATIONAL
  • 2009-09. Low-Energy Femoral Fractures Associated with the Long-Term Use of Bisphosphonates in DRUG SAFETY
  • 2008-05. Alendronate Reduces Bone Toughness of Ribs without Significantly Increasing Microdamage Accumulation in Dogs Following 3 Years of Daily Treatment in CALCIFIED TISSUE INTERNATIONAL
  • 2008-01. Bone quality: the material and structural basis of bone strength in JOURNAL OF BONE AND MINERAL METABOLISM
  • 2007-06. Nanoscale heterogeneity promotes energy dissipation in bone in NATURE MATERIALS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11914-014-0200-9

    DOI

    http://dx.doi.org/10.1007/s11914-014-0200-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1042404381

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24615358


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    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11914-014-0200-9'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11914-014-0200-9'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11914-014-0200-9'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11914-014-0200-9'


     

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