Bone, Inflammation, and Inflammatory Bowel Disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-12

AUTHORS

Manasi Agrawal, Shitij Arora, Jianjun Li, Rabin Rahmani, Li Sun, Adam F. Steinlauf, Jeffrey I. Mechanick, Mone Zaidi

ABSTRACT

Osteoporosis is a leading cause of morbidity in patients with inflammatory bowel disease (IBD). Bone loss is an early systemic process and occurs even before clinical disease manifests. Bone disease is attributed to vitamin D deficiency, steroid use, and/or systemic inflammation. In this review, we discuss the molecular pathways of bone loss mediated by inflammatory cytokines and other mediators. Further research will hopefully clarify the mechanisms of inflammation-induced bone loss in IBD and guide effective treatment modalities. More... »

PAGES

251

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11914-011-0077-9

DOI

http://dx.doi.org/10.1007/s11914-011-0077-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002697037

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21935582


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