Trends in Management of Oligometastatic Hormone-Sensitive Prostate Cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-05

AUTHORS

Gargi Kothari, Piet Ost, Patrick Cheung, Pierre Blanchard, Alison C. Tree, Nicholas J. van As, Simon S. Lo, Drew Moghanaki, Andrew Loblaw, Shankar Siva

ABSTRACT

PURPOSE OF REVIEW: Systemic therapy for patients with hormone-sensitive oligometastatic prostate cancer is non-curative and associated with toxicities. Meanwhile, this population presents unique clinical opportunities to improve outcomes, including the demonstrated benefits of radiotherapy to the primary tumor or oligometastatic sites. RECENT FINDINGS: Recently published randomized studies have demonstrated benefits with the addition of radiotherapy to the primary disease or metastatic lesions in patients with synchronous or metachronous disease. The introduction of novel PET imaging has improved the sensitivity and specificity for detecting metastatic disease and provides an opportunity to better select patients who will benefit from local therapy. The data presented in this review supports revisiting practice guidelines for patients with hormone-sensitive metastatic prostate cancer, particularly in relation to the role of radiotherapy to the primary tumor and sites of oligometastatic disease. Future trials will aim to further establish the role of metastasis-directed therapies in metachronous, synchronous, and castrate-resistant disease. More... »

PAGES

43

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11912-019-0791-5

    DOI

    http://dx.doi.org/10.1007/s11912-019-0791-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113042094

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30919165


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