Targeting DNA Repair Defects for Precision Medicine in Prostate Cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-05

AUTHORS

Alejandro Athie, Sara Arce-Gallego, Macarena Gonzalez, Rafael Morales-Barrera, Cristina Suarez, Teresa Casals Galobart, Gonzalo Hernandez Viedma, Joan Carles, Joaquin Mateo

ABSTRACT

PURPOSE OF REVIEW: Genomic studies of localized and metastatic prostate cancer have identified a high prevalence of clinically actionable alterations including mutations in DNA repair genes. In this manuscript, we review the current knowledge on DNA repair defects in prostate cancer and provide an overview of how these alterations can be targeted towards a personalized prostate cancer management. RECENT FINDINGS: Twenty to 25% of metastatic prostate cancers harbor defects in DNA repair genes, most commonly in the homologous recombination genes. These defects confer increased sensitivity to platinum chemotherapy or poly (ADP-ribose) polymerase (PARP) inhibitors. Recent trials also support a synergistic effect of combining these therapies with androgen receptor-targeting agents. Identification of mismatch-repair defects could result in defining a prostate cancer population who may benefit from immune checkpoint inhibitors. These data have implications for family testing and early diagnosis, as many of these mutations are linked to inherited risk of prostate cancer. The DNA damage repair pathways are clinically relevant in prostate cancer, being a target for precision medicine; combination with standard-of-care androgen receptor (AR)-targeting agents may be synergistic. More... »

PAGES

42

References to SciGraph publications

  • 2017-12. Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer in NATURE COMMUNICATIONS
  • 2014-11. Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens in NATURE
  • 2005-04. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy in NATURE
  • 2011-07. Unraveling the mechanism of BRCA2 in homologous recombination in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2014-12. Complex MSH2 and MSH6 mutations in hypermutated microsatellite unstable advanced prostate cancer in NATURE COMMUNICATIONS
  • 2014-03. Frequent germline deleterious mutations in DNA repair genes in familial prostate cancer cases are associated with advanced disease in BRITISH JOURNAL OF CANCER
  • 2005-04. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase in NATURE
  • 2018-09. Copy number signatures and mutational processes in ovarian carcinoma in NATURE GENETICS
  • 2015-05. DNA damage response and prostate cancer: defects, regulation and therapeutic implications in ONCOGENE
  • 2008-01. Homologous recombination in DNA repair and DNA damage tolerance in CELL RESEARCH
  • 2011-10. BRCA2 is a moderate penetrance gene contributing to young-onset prostate cancer: implications for genetic testing in prostate cancer patients in BRITISH JOURNAL OF CANCER
  • 2016-04. Substantial interindividual and limited intraindividual genomic diversity among tumors from men with metastatic prostate cancer in NATURE MEDICINE
  • 2017-06. Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients in NATURE MEDICINE
  • 2012-07. The mutational landscape of lethal castration-resistant prostate cancer in NATURE
  • 2013-08. Signatures of mutational processes in human cancer in NATURE
  • 2018-05. The long tail of oncogenic drivers in prostate cancer in NATURE GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11912-019-0790-6

    DOI

    http://dx.doi.org/10.1007/s11912-019-0790-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113048234

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30919167


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Hospital Universitari Vall d'Hebron", 
              "id": "https://www.grid.ac/institutes/grid.411083.f", 
              "name": [
                "Prostate Cancer Translational Research Group, Vall d\u2019Hebron Institute of Oncology (VHIO), Cellex Center, Natzaret 115-117, 08035, Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Athie", 
            "givenName": "Alejandro", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital Universitari Vall d'Hebron", 
              "id": "https://www.grid.ac/institutes/grid.411083.f", 
              "name": [
                "Prostate Cancer Translational Research Group, Vall d\u2019Hebron Institute of Oncology (VHIO), Cellex Center, Natzaret 115-117, 08035, Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Arce-Gallego", 
            "givenName": "Sara", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital Universitari Vall d'Hebron", 
              "id": "https://www.grid.ac/institutes/grid.411083.f", 
              "name": [
                "Prostate Cancer Translational Research Group, Vall d\u2019Hebron Institute of Oncology (VHIO), Cellex Center, Natzaret 115-117, 08035, Barcelona, Spain", 
                "Department of Medical Oncology, Vall d\u2019Hebron University Hospital, Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gonzalez", 
            "givenName": "Macarena", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital Universitari Vall d'Hebron", 
              "id": "https://www.grid.ac/institutes/grid.411083.f", 
              "name": [
                "Prostate Cancer Translational Research Group, Vall d\u2019Hebron Institute of Oncology (VHIO), Cellex Center, Natzaret 115-117, 08035, Barcelona, Spain", 
                "Department of Medical Oncology, Vall d\u2019Hebron University Hospital, Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Morales-Barrera", 
            "givenName": "Rafael", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital Universitari Vall d'Hebron", 
              "id": "https://www.grid.ac/institutes/grid.411083.f", 
              "name": [
                "Prostate Cancer Translational Research Group, Vall d\u2019Hebron Institute of Oncology (VHIO), Cellex Center, Natzaret 115-117, 08035, Barcelona, Spain", 
                "Department of Medical Oncology, Vall d\u2019Hebron University Hospital, Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Suarez", 
            "givenName": "Cristina", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital Universitari Vall d'Hebron", 
              "id": "https://www.grid.ac/institutes/grid.411083.f", 
              "name": [
                "Prostate Cancer Translational Research Group, Vall d\u2019Hebron Institute of Oncology (VHIO), Cellex Center, Natzaret 115-117, 08035, Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Casals Galobart", 
            "givenName": "Teresa", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital Universitari Vall d'Hebron", 
              "id": "https://www.grid.ac/institutes/grid.411083.f", 
              "name": [
                "Prostate Cancer Translational Research Group, Vall d\u2019Hebron Institute of Oncology (VHIO), Cellex Center, Natzaret 115-117, 08035, Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hernandez Viedma", 
            "givenName": "Gonzalo", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital Universitari Vall d'Hebron", 
              "id": "https://www.grid.ac/institutes/grid.411083.f", 
              "name": [
                "Prostate Cancer Translational Research Group, Vall d\u2019Hebron Institute of Oncology (VHIO), Cellex Center, Natzaret 115-117, 08035, Barcelona, Spain", 
                "Department of Medical Oncology, Vall d\u2019Hebron University Hospital, Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Carles", 
            "givenName": "Joan", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital Universitari Vall d'Hebron", 
              "id": "https://www.grid.ac/institutes/grid.411083.f", 
              "name": [
                "Prostate Cancer Translational Research Group, Vall d\u2019Hebron Institute of Oncology (VHIO), Cellex Center, Natzaret 115-117, 08035, Barcelona, Spain", 
                "Department of Medical Oncology, Vall d\u2019Hebron University Hospital, Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mateo", 
            "givenName": "Joaquin", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/s0140-6736(10)60892-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000475882"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/9781444323146.ch30", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001008509"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2015.05.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001625886"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2015.05.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001625886"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11125", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002334898", 
              "https://doi.org/10.1038/nature11125"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.aad0095", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005715050"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms5988", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009369436", 
              "https://doi.org/10.1038/ncomms5988"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.eururo.2015.11.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012075864"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.eururo.2015.11.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012075864"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.01639-13", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012340504"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2159-8290.cd-13-0172", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012391852"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2159-8290.cd-13-0108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012667301"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2011.383", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013288998", 
              "https://doi.org/10.1038/bjc.2011.383"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1506859", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013460718"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2014.238", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014883368", 
              "https://doi.org/10.1038/onc.2014.238"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1611310", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016743702"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13988", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017863023", 
              "https://doi.org/10.1038/nature13988"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.eururo.2016.11.033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018915285"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.eururo.2016.11.033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018915285"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-13-1262", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019202847"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2011.02.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023540354"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.10547", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026024113"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2010.09.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027198160"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.2096", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028744825", 
              "https://doi.org/10.1038/nsmb.2096"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2015.10.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028836563"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-12-3791", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030994707"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1105535", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032056158"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.thorsurg.2014.12.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032347522"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa0900212", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036199013"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03443", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036499081", 
              "https://doi.org/10.1038/nature03443"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03443", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036499081", 
              "https://doi.org/10.1038/nature03443"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2012.43.1882", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038191784"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/345310", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039137551"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/345310", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039137551"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03445", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039649759", 
              "https://doi.org/10.1038/nature03445"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03445", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039649759", 
              "https://doi.org/10.1038/nature03445"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2011.04.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040091914"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1603144", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040573458"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1603144", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040573458"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cr.2008.1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040825790", 
              "https://doi.org/10.1038/cr.2008.1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.4053", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043166959", 
              "https://doi.org/10.1038/nm.4053"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(13)70240-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045417978"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.eururo.2014.10.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047383924"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2159-8290.cd-12-0120", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049284389"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12477", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050004918", 
              "https://doi.org/10.1038/nature12477"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2014.30", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050250340", 
              "https://doi.org/10.1038/bjc.2014.30"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.eururo.2012.08.053", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050464995"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2009.23.9764", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052849919"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(16)30559-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052969020"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(16)30559-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052969020"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(16)30559-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052969020"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(16)30559-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052969020"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1500596", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053017729"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2159-8290.cd-16-0860", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063281075"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2014.56.2728", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064204398"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.eururo.2017.02.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084074066"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.4333", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085214027", 
              "https://doi.org/10.1038/nm.4333"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.4333", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085214027", 
              "https://doi.org/10.1038/nm.4333"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2159-8290.cd-17-0261", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085284387"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scisignal.aam7479", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085572993"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1706450", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085864115"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1704174", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085864278"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.aan6733", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085942187"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.aan6733", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085942187"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/po.17.00029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090381375"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.mrrev.2017.07.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090573570"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1538-7445.am2017-4745", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091006443"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41467-017-00393-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091331665", 
              "https://doi.org/10.1038/s41467-017-00393-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2159-8290.cd-17-0937", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100618736"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2159-8290.cd-17-0937", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100618736"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.eururo.2018.01.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100918197"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.eururo.2018.01.035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100961201"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2018.36.6_suppl.tps388", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101229978"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/cshperspect.a030486", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101562964"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41588-018-0078-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101722693", 
              "https://doi.org/10.1038/s41588-018-0078-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41588-018-0078-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101722693", 
              "https://doi.org/10.1038/s41588-018-0078-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.tm118.000372", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101836647"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2017.76.4126", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103279718"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdy099", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103281414"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci96769", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104376390"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(18)30365-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104380589"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(18)30365-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104380589"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2018.04.034", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104598018"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2018.04.034", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104598018"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2018.04.034", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104598018"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1800536", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105173343"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdy232", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105408898"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2018.06.039", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105710388"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2018.06.039", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105710388"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2018.06.039", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105710388"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2018.06.039", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105710388"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41588-018-0179-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106088133", 
              "https://doi.org/10.1038/s41588-018-0179-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41588-018-0179-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106088133", 
              "https://doi.org/10.1038/s41588-018-0179-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41588-018-0179-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106088133", 
              "https://doi.org/10.1038/s41588-018-0179-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41588-018-0179-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106088133", 
              "https://doi.org/10.1038/s41588-018-0179-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2018.36.15_suppl.5007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106715194"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.eururo.2018.09.021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107481695"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.eururo.2018.10.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107647640"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.eururo.2018.10.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107647640"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.eururo.2018.10.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107647640"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.eururo.2018.09.048", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107661370"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.eururo.2018.09.048", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107661370"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.eururo.2018.09.048", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107661370"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1810858", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107744361"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.15252/emmm.201708816", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110099751"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.15252/emmm.201708816", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110099751"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.15252/emmm.201708816", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110099751"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.15252/emmm.201708816", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110099751"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jamaoncol.2018.5801", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110925506"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jamaoncol.2018.5801", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110925506"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jamaoncol.2018.5801", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110925506"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.18.00358", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1111331178"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-05", 
        "datePublishedReg": "2019-05-01", 
        "description": "PURPOSE OF REVIEW: Genomic studies of localized and metastatic prostate cancer have identified a high prevalence of clinically actionable alterations including mutations in DNA repair genes. In this manuscript, we review the current knowledge on DNA repair defects in prostate cancer and provide an overview of how these alterations can be targeted towards a personalized prostate cancer management.\nRECENT FINDINGS: Twenty to 25% of metastatic prostate cancers harbor defects in DNA repair genes, most commonly in the homologous recombination genes. These defects confer increased sensitivity to platinum chemotherapy or poly (ADP-ribose) polymerase (PARP) inhibitors. Recent trials also support a synergistic effect of combining these therapies with androgen receptor-targeting agents. Identification of mismatch-repair defects could result in defining a prostate cancer population who may benefit from immune checkpoint inhibitors. These data have implications for family testing and early diagnosis, as many of these mutations are linked to inherited risk of prostate cancer. The DNA damage repair pathways are clinically relevant in prostate cancer, being a target for precision medicine; combination with standard-of-care androgen receptor (AR)-targeting agents may be synergistic.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s11912-019-0790-6", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1021174", 
            "issn": [
              "1523-3790", 
              "1534-6269"
            ], 
            "name": "Current Oncology Reports", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "5", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "21"
          }
        ], 
        "name": "Targeting DNA Repair Defects for Precision Medicine in Prostate Cancer", 
        "pagination": "42", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "d9315333e26de73aa729ae9f96c7b92f0ce0bb05e5ccc71d35ff99a0e06e1ead"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30919167"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "100888967"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s11912-019-0790-6"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1113048234"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s11912-019-0790-6", 
          "https://app.dimensions.ai/details/publication/pub.1113048234"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T13:29", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000370_0000000370/records_46747_00000003.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1007%2Fs11912-019-0790-6"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11912-019-0790-6'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11912-019-0790-6'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11912-019-0790-6'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11912-019-0790-6'


     

    This table displays all metadata directly associated to this object as RDF triples.

    373 TRIPLES      21 PREDICATES      109 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s11912-019-0790-6 schema:about anzsrc-for:11
    2 anzsrc-for:1112
    3 schema:author N1e95ec1a797e443cbea5d890a1fdceeb
    4 schema:citation sg:pub.10.1038/bjc.2011.383
    5 sg:pub.10.1038/bjc.2014.30
    6 sg:pub.10.1038/cr.2008.1
    7 sg:pub.10.1038/nature03443
    8 sg:pub.10.1038/nature03445
    9 sg:pub.10.1038/nature11125
    10 sg:pub.10.1038/nature12477
    11 sg:pub.10.1038/nature13988
    12 sg:pub.10.1038/ncomms5988
    13 sg:pub.10.1038/nm.4053
    14 sg:pub.10.1038/nm.4333
    15 sg:pub.10.1038/nsmb.2096
    16 sg:pub.10.1038/onc.2014.238
    17 sg:pub.10.1038/s41467-017-00393-y
    18 sg:pub.10.1038/s41588-018-0078-z
    19 sg:pub.10.1038/s41588-018-0179-8
    20 https://doi.org/10.1001/jamaoncol.2018.5801
    21 https://doi.org/10.1002/9781444323146.ch30
    22 https://doi.org/10.1016/j.ccr.2011.04.010
    23 https://doi.org/10.1016/j.cell.2011.02.013
    24 https://doi.org/10.1016/j.cell.2015.05.001
    25 https://doi.org/10.1016/j.cell.2015.10.025
    26 https://doi.org/10.1016/j.cell.2018.04.034
    27 https://doi.org/10.1016/j.cell.2018.06.039
    28 https://doi.org/10.1016/j.eururo.2012.08.053
    29 https://doi.org/10.1016/j.eururo.2014.10.022
    30 https://doi.org/10.1016/j.eururo.2015.11.022
    31 https://doi.org/10.1016/j.eururo.2016.11.033
    32 https://doi.org/10.1016/j.eururo.2017.02.023
    33 https://doi.org/10.1016/j.eururo.2018.01.010
    34 https://doi.org/10.1016/j.eururo.2018.01.035
    35 https://doi.org/10.1016/j.eururo.2018.09.021
    36 https://doi.org/10.1016/j.eururo.2018.09.048
    37 https://doi.org/10.1016/j.eururo.2018.10.009
    38 https://doi.org/10.1016/j.molcel.2010.09.019
    39 https://doi.org/10.1016/j.mrrev.2017.07.001
    40 https://doi.org/10.1016/j.thorsurg.2014.12.003
    41 https://doi.org/10.1016/s0140-6736(10)60892-6
    42 https://doi.org/10.1016/s1470-2045(13)70240-7
    43 https://doi.org/10.1016/s1470-2045(16)30559-9
    44 https://doi.org/10.1016/s1470-2045(18)30365-6
    45 https://doi.org/10.1056/nejmoa0900212
    46 https://doi.org/10.1056/nejmoa1105535
    47 https://doi.org/10.1056/nejmoa1500596
    48 https://doi.org/10.1056/nejmoa1506859
    49 https://doi.org/10.1056/nejmoa1603144
    50 https://doi.org/10.1056/nejmoa1611310
    51 https://doi.org/10.1056/nejmoa1704174
    52 https://doi.org/10.1056/nejmoa1706450
    53 https://doi.org/10.1056/nejmoa1800536
    54 https://doi.org/10.1056/nejmoa1810858
    55 https://doi.org/10.1074/jbc.tm118.000372
    56 https://doi.org/10.1086/345310
    57 https://doi.org/10.1093/annonc/mdy099
    58 https://doi.org/10.1093/annonc/mdy232
    59 https://doi.org/10.1101/cshperspect.a030486
    60 https://doi.org/10.1126/science.aad0095
    61 https://doi.org/10.1126/science.aan6733
    62 https://doi.org/10.1126/scisignal.aam7479
    63 https://doi.org/10.1128/mcb.01639-13
    64 https://doi.org/10.1158/1078-0432.ccr-12-3791
    65 https://doi.org/10.1158/1078-0432.ccr-13-1262
    66 https://doi.org/10.1158/1538-7445.am2017-4745
    67 https://doi.org/10.1158/2159-8290.cd-12-0120
    68 https://doi.org/10.1158/2159-8290.cd-13-0108
    69 https://doi.org/10.1158/2159-8290.cd-13-0172
    70 https://doi.org/10.1158/2159-8290.cd-16-0860
    71 https://doi.org/10.1158/2159-8290.cd-17-0261
    72 https://doi.org/10.1158/2159-8290.cd-17-0937
    73 https://doi.org/10.1172/jci96769
    74 https://doi.org/10.1200/jco.18.00358
    75 https://doi.org/10.1200/jco.2009.23.9764
    76 https://doi.org/10.1200/jco.2012.43.1882
    77 https://doi.org/10.1200/jco.2014.56.2728
    78 https://doi.org/10.1200/jco.2017.76.4126
    79 https://doi.org/10.1200/jco.2018.36.15_suppl.5007
    80 https://doi.org/10.1200/jco.2018.36.6_suppl.tps388
    81 https://doi.org/10.1200/po.17.00029
    82 https://doi.org/10.15252/emmm.201708816
    83 https://doi.org/10.18632/oncotarget.10547
    84 schema:datePublished 2019-05
    85 schema:datePublishedReg 2019-05-01
    86 schema:description PURPOSE OF REVIEW: Genomic studies of localized and metastatic prostate cancer have identified a high prevalence of clinically actionable alterations including mutations in DNA repair genes. In this manuscript, we review the current knowledge on DNA repair defects in prostate cancer and provide an overview of how these alterations can be targeted towards a personalized prostate cancer management. RECENT FINDINGS: Twenty to 25% of metastatic prostate cancers harbor defects in DNA repair genes, most commonly in the homologous recombination genes. These defects confer increased sensitivity to platinum chemotherapy or poly (ADP-ribose) polymerase (PARP) inhibitors. Recent trials also support a synergistic effect of combining these therapies with androgen receptor-targeting agents. Identification of mismatch-repair defects could result in defining a prostate cancer population who may benefit from immune checkpoint inhibitors. These data have implications for family testing and early diagnosis, as many of these mutations are linked to inherited risk of prostate cancer. The DNA damage repair pathways are clinically relevant in prostate cancer, being a target for precision medicine; combination with standard-of-care androgen receptor (AR)-targeting agents may be synergistic.
    87 schema:genre research_article
    88 schema:inLanguage en
    89 schema:isAccessibleForFree false
    90 schema:isPartOf N814d2b4fc9654c98b4b14300674854f2
    91 Nd083cdccfc7a4c79991f3ced4af6245f
    92 sg:journal.1021174
    93 schema:name Targeting DNA Repair Defects for Precision Medicine in Prostate Cancer
    94 schema:pagination 42
    95 schema:productId N557ede6f1f2c493ea1061836bbd3ee9d
    96 N8f1f955b285741d1a5fa14a3b8be82ff
    97 Nc76ffed172454c9db0f8936c576967d1
    98 Nd1277a05ea7f4208b3571458f724d7b6
    99 Ne461dafedebf491ea22e16e8ae2e8cbd
    100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113048234
    101 https://doi.org/10.1007/s11912-019-0790-6
    102 schema:sdDatePublished 2019-04-11T13:29
    103 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    104 schema:sdPublisher N1d45a848394b49d7b25d685f6a345fe8
    105 schema:url https://link.springer.com/10.1007%2Fs11912-019-0790-6
    106 sgo:license sg:explorer/license/
    107 sgo:sdDataset articles
    108 rdf:type schema:ScholarlyArticle
    109 N05c87fd95c154e06954bbd7b73c8372a schema:affiliation https://www.grid.ac/institutes/grid.411083.f
    110 schema:familyName Casals Galobart
    111 schema:givenName Teresa
    112 rdf:type schema:Person
    113 N1d45a848394b49d7b25d685f6a345fe8 schema:name Springer Nature - SN SciGraph project
    114 rdf:type schema:Organization
    115 N1e95ec1a797e443cbea5d890a1fdceeb rdf:first Ndaa46b505a624fc7b4dd4d0943a2aaee
    116 rdf:rest Na024f0397a19487eae2132152b28d7b3
    117 N391dae4e84b444ed91d7f8c913c78fe8 schema:affiliation https://www.grid.ac/institutes/grid.411083.f
    118 schema:familyName Carles
    119 schema:givenName Joan
    120 rdf:type schema:Person
    121 N3a1d0d64501a472ebc430ec25411df2d rdf:first N391dae4e84b444ed91d7f8c913c78fe8
    122 rdf:rest Ne8b2e9222ee6476ea5b7898bfcd5a49b
    123 N53faa29d358840959e9dec8f5cc83131 schema:affiliation https://www.grid.ac/institutes/grid.411083.f
    124 schema:familyName Arce-Gallego
    125 schema:givenName Sara
    126 rdf:type schema:Person
    127 N557ede6f1f2c493ea1061836bbd3ee9d schema:name pubmed_id
    128 schema:value 30919167
    129 rdf:type schema:PropertyValue
    130 N57627a64c3eb472db9a0c11fa1418879 rdf:first Nc4d1ca2cf2f14af3b82408f5c597c308
    131 rdf:rest Nc8ba16e5d6be41c680132b729f0892c6
    132 N814d2b4fc9654c98b4b14300674854f2 schema:issueNumber 5
    133 rdf:type schema:PublicationIssue
    134 N8364782024ed4457be95be05f137e336 schema:affiliation https://www.grid.ac/institutes/grid.411083.f
    135 schema:familyName Mateo
    136 schema:givenName Joaquin
    137 rdf:type schema:Person
    138 N8f1f955b285741d1a5fa14a3b8be82ff schema:name readcube_id
    139 schema:value d9315333e26de73aa729ae9f96c7b92f0ce0bb05e5ccc71d35ff99a0e06e1ead
    140 rdf:type schema:PropertyValue
    141 N9f813e723229405aa107c43e214c668c schema:affiliation https://www.grid.ac/institutes/grid.411083.f
    142 schema:familyName Hernandez Viedma
    143 schema:givenName Gonzalo
    144 rdf:type schema:Person
    145 Na024f0397a19487eae2132152b28d7b3 rdf:first N53faa29d358840959e9dec8f5cc83131
    146 rdf:rest N57627a64c3eb472db9a0c11fa1418879
    147 Nb01541bc510843e59edaf50a8f4d4277 rdf:first Nd637dfaa34894d42a25589d184f08315
    148 rdf:rest Nccfc737c81ad4dfabc905afe38e89f66
    149 Nc4d1ca2cf2f14af3b82408f5c597c308 schema:affiliation https://www.grid.ac/institutes/grid.411083.f
    150 schema:familyName Gonzalez
    151 schema:givenName Macarena
    152 rdf:type schema:Person
    153 Nc76ffed172454c9db0f8936c576967d1 schema:name dimensions_id
    154 schema:value pub.1113048234
    155 rdf:type schema:PropertyValue
    156 Nc8ba16e5d6be41c680132b729f0892c6 rdf:first Nd446a9296d674497ba716bcce5903239
    157 rdf:rest Nb01541bc510843e59edaf50a8f4d4277
    158 Nccfc737c81ad4dfabc905afe38e89f66 rdf:first N05c87fd95c154e06954bbd7b73c8372a
    159 rdf:rest Neddc7f86a5cf4bcf9ceaea92ae110750
    160 Nd083cdccfc7a4c79991f3ced4af6245f schema:volumeNumber 21
    161 rdf:type schema:PublicationVolume
    162 Nd1277a05ea7f4208b3571458f724d7b6 schema:name nlm_unique_id
    163 schema:value 100888967
    164 rdf:type schema:PropertyValue
    165 Nd446a9296d674497ba716bcce5903239 schema:affiliation https://www.grid.ac/institutes/grid.411083.f
    166 schema:familyName Morales-Barrera
    167 schema:givenName Rafael
    168 rdf:type schema:Person
    169 Nd637dfaa34894d42a25589d184f08315 schema:affiliation https://www.grid.ac/institutes/grid.411083.f
    170 schema:familyName Suarez
    171 schema:givenName Cristina
    172 rdf:type schema:Person
    173 Ndaa46b505a624fc7b4dd4d0943a2aaee schema:affiliation https://www.grid.ac/institutes/grid.411083.f
    174 schema:familyName Athie
    175 schema:givenName Alejandro
    176 rdf:type schema:Person
    177 Ne461dafedebf491ea22e16e8ae2e8cbd schema:name doi
    178 schema:value 10.1007/s11912-019-0790-6
    179 rdf:type schema:PropertyValue
    180 Ne8b2e9222ee6476ea5b7898bfcd5a49b rdf:first N8364782024ed4457be95be05f137e336
    181 rdf:rest rdf:nil
    182 Neddc7f86a5cf4bcf9ceaea92ae110750 rdf:first N9f813e723229405aa107c43e214c668c
    183 rdf:rest N3a1d0d64501a472ebc430ec25411df2d
    184 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    185 schema:name Medical and Health Sciences
    186 rdf:type schema:DefinedTerm
    187 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    188 schema:name Oncology and Carcinogenesis
    189 rdf:type schema:DefinedTerm
    190 sg:journal.1021174 schema:issn 1523-3790
    191 1534-6269
    192 schema:name Current Oncology Reports
    193 rdf:type schema:Periodical
    194 sg:pub.10.1038/bjc.2011.383 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013288998
    195 https://doi.org/10.1038/bjc.2011.383
    196 rdf:type schema:CreativeWork
    197 sg:pub.10.1038/bjc.2014.30 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050250340
    198 https://doi.org/10.1038/bjc.2014.30
    199 rdf:type schema:CreativeWork
    200 sg:pub.10.1038/cr.2008.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040825790
    201 https://doi.org/10.1038/cr.2008.1
    202 rdf:type schema:CreativeWork
    203 sg:pub.10.1038/nature03443 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036499081
    204 https://doi.org/10.1038/nature03443
    205 rdf:type schema:CreativeWork
    206 sg:pub.10.1038/nature03445 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039649759
    207 https://doi.org/10.1038/nature03445
    208 rdf:type schema:CreativeWork
    209 sg:pub.10.1038/nature11125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002334898
    210 https://doi.org/10.1038/nature11125
    211 rdf:type schema:CreativeWork
    212 sg:pub.10.1038/nature12477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050004918
    213 https://doi.org/10.1038/nature12477
    214 rdf:type schema:CreativeWork
    215 sg:pub.10.1038/nature13988 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017863023
    216 https://doi.org/10.1038/nature13988
    217 rdf:type schema:CreativeWork
    218 sg:pub.10.1038/ncomms5988 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009369436
    219 https://doi.org/10.1038/ncomms5988
    220 rdf:type schema:CreativeWork
    221 sg:pub.10.1038/nm.4053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043166959
    222 https://doi.org/10.1038/nm.4053
    223 rdf:type schema:CreativeWork
    224 sg:pub.10.1038/nm.4333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085214027
    225 https://doi.org/10.1038/nm.4333
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1038/nsmb.2096 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028744825
    228 https://doi.org/10.1038/nsmb.2096
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1038/onc.2014.238 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014883368
    231 https://doi.org/10.1038/onc.2014.238
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1038/s41467-017-00393-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1091331665
    234 https://doi.org/10.1038/s41467-017-00393-y
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1038/s41588-018-0078-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1101722693
    237 https://doi.org/10.1038/s41588-018-0078-z
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1038/s41588-018-0179-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106088133
    240 https://doi.org/10.1038/s41588-018-0179-8
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1001/jamaoncol.2018.5801 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110925506
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1002/9781444323146.ch30 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001008509
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.1016/j.ccr.2011.04.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040091914
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.1016/j.cell.2011.02.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023540354
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.1016/j.cell.2015.05.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001625886
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.1016/j.cell.2015.10.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028836563
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.1016/j.cell.2018.04.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104598018
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1016/j.cell.2018.06.039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105710388
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1016/j.eururo.2012.08.053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050464995
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1016/j.eururo.2014.10.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047383924
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1016/j.eururo.2015.11.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012075864
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1016/j.eururo.2016.11.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018915285
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1016/j.eururo.2017.02.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084074066
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1016/j.eururo.2018.01.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100918197
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1016/j.eururo.2018.01.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100961201
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1016/j.eururo.2018.09.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107481695
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1016/j.eururo.2018.09.048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107661370
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1016/j.eururo.2018.10.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107647640
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1016/j.molcel.2010.09.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027198160
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1016/j.mrrev.2017.07.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090573570
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1016/j.thorsurg.2014.12.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032347522
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1016/s0140-6736(10)60892-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000475882
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1016/s1470-2045(13)70240-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045417978
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1016/s1470-2045(16)30559-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052969020
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1016/s1470-2045(18)30365-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104380589
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1056/nejmoa0900212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036199013
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1056/nejmoa1105535 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032056158
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1056/nejmoa1500596 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053017729
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1056/nejmoa1506859 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013460718
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1056/nejmoa1603144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040573458
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1056/nejmoa1611310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016743702
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1056/nejmoa1704174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085864278
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1056/nejmoa1706450 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085864115
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1056/nejmoa1800536 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105173343
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1056/nejmoa1810858 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107744361
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1074/jbc.tm118.000372 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101836647
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1086/345310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039137551
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1093/annonc/mdy099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103281414
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1093/annonc/mdy232 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105408898
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1101/cshperspect.a030486 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101562964
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1126/science.aad0095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005715050
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1126/science.aan6733 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085942187
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1126/scisignal.aam7479 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085572993
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1128/mcb.01639-13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012340504
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1158/1078-0432.ccr-12-3791 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030994707
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1158/1078-0432.ccr-13-1262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019202847
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1158/1538-7445.am2017-4745 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091006443
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1158/2159-8290.cd-12-0120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049284389
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1158/2159-8290.cd-13-0108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012667301
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1158/2159-8290.cd-13-0172 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012391852
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1158/2159-8290.cd-16-0860 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063281075
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1158/2159-8290.cd-17-0261 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085284387
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1158/2159-8290.cd-17-0937 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100618736
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1172/jci96769 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104376390
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1200/jco.18.00358 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111331178
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1200/jco.2009.23.9764 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052849919
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1200/jco.2012.43.1882 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038191784
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1200/jco.2014.56.2728 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064204398
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1200/jco.2017.76.4126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103279718
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1200/jco.2018.36.15_suppl.5007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106715194
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1200/jco.2018.36.6_suppl.tps388 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101229978
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1200/po.17.00029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090381375
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.15252/emmm.201708816 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110099751
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.18632/oncotarget.10547 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026024113
    369 rdf:type schema:CreativeWork
    370 https://www.grid.ac/institutes/grid.411083.f schema:alternateName Hospital Universitari Vall d'Hebron
    371 schema:name Department of Medical Oncology, Vall d’Hebron University Hospital, Barcelona, Spain
    372 Prostate Cancer Translational Research Group, Vall d’Hebron Institute of Oncology (VHIO), Cellex Center, Natzaret 115-117, 08035, Barcelona, Spain
    373 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...