Bispecific Antibodies in Hematologic Malignancies: When, to Whom, and How Should Be Best Used? View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-02

AUTHORS

Roberta Demichelis-Gómez, Daniela Pérez-Sámano, Christianne Bourlon

ABSTRACT

PURPOSE OF REVIEW: The purpose of this review is to discuss the current recommendations for the use of bispecific antibodies (bsAb) in hematologic malignancies and explore the future in this field. RECENT FINDINGS: Bispecific antibodies are molecules able to target two different antigen-binding sites: one towards a tumor antigen and another to activate a cytotoxic cell. Phase II/III trials on blinatumomab for acute lymphoblastic leukemia (ALL) have demonstrated its efficacy for treating minimal residual disease (MRD+) and relapsed refractory (r/r) Philadelphia positive (Ph+) and negative (Ph-) ALL in adults and children. Currently, the only bispecific antibody (bsAb) approved for its use in hematologic malignancies is blinatumomab. However, multiple trials are under development not only to explore blinatumomab's clinical activity in other neoplasia, such as lymphoma or multiple myeloma, but also to develop new molecules against different antigens. More... »

PAGES

17

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11912-019-0759-5

DOI

http://dx.doi.org/10.1007/s11912-019-0759-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111911177

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30715609


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