Improving Systemic Chemotherapy for Bladder Cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-05

AUTHORS

Tracy L. Rose, Matthew I. Milowsky

ABSTRACT

Systemic chemotherapy is integral to the management of muscle-invasive and metastatic bladder cancer (BCa). Neoadjuvant chemotherapy has been increasingly utilized for muscle-invasive BCa over the past several years, and several options for cisplatin-based regimens have emerged. Adjuvant chemotherapy may be considered for select patients who did not receive neoadjuvant therapy. Systemic chemotherapy added to radiotherapy is a critical component of a bladder-preserving approach and superior to radiotherapy alone. Cisplatin-based chemotherapy has been the mainstay for metastatic BCa for more than three decades. Novel targeted agents are in development fueled by the recent molecular characterization of BCa. Recent trials of immunotherapy have demonstrated the possibility of a less toxic and potentially more effective treatment for metastatic disease. It is an extremely exciting time for BCa research, and much needed improvements in systemic treatment are most certainly on the horizon. More... »

PAGES

27

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11912-016-0512-2

DOI

http://dx.doi.org/10.1007/s11912-016-0512-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045626994

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26984414


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