Driver Mutations in Melanoma: Lessons Learned From Bench-to-Bedside Studies View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-10

AUTHORS

Janice M. Mehnert, Harriet M. Kluger

ABSTRACT

The identification of somatic driver mutations in human samples has allowed for the development of a molecular classification for melanoma. Recent breakthroughs in the treatment of metastatic melanoma have arisen as a result of these significant new insights into the molecular biology of the disease, particularly the development of inhibitors of activating BRAF(V600E) mutations. In this article the roles of several mutations known to be involved in the malignant transformation of melanocytes are reviewed including BRAF, PTEN, NRAS, ckit, and p16 as well as some of the emerging mutations in cutaneous and uveal melanoma. The bench to bedside collaborations that resulted in these discoveries are summarized, and potential therapeutic strategies to target driver mutations in specific patient subsets are discussed. More... »

PAGES

449-457

References to SciGraph publications

  • 2011-07. BRAF targeted therapy changes the treatment paradigm in melanoma in NATURE REVIEWS CLINICAL ONCOLOGY
  • 2010-12. Epigenetics of human cutaneous melanoma: setting the stage for new therapeutic strategies in JOURNAL OF TRANSLATIONAL MEDICINE
  • 2010-12. Incidence of the V600K mutation among melanoma patients with BRAF mutations, and potential therapeutic response to the specific BRAF inhibitor PLX4032 in JOURNAL OF TRANSLATIONAL MEDICINE
  • 2005-04. Lack of clinical efficacy of imatinib in metastatic melanoma in BRITISH JOURNAL OF CANCER
  • 2002-06. Mutations of the BRAF gene in human cancer in NATURE
  • 2003-05. PTEN signaling pathways in melanoma in ONCOGENE
  • 2004-02. Imatinib Mesylate Inhibits Platelet-Derived Growth Factor Receptor Phosphorylation of Melanoma Cells But Does Not Affect Tumorigenicity In Vivo in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1998-07. Identification of PTEN/MMAC1 alterations in uncultured melanomas and melanoma cell lines in ONCOGENE
  • 2012-02. Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing in NATURE GENETICS
  • 2011-10-19. A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma in NATURE
  • 2005-07. Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma in NATURE
  • 2008-06. In melanocytic lesions the fraction of BRAFV600E alleles is associated with sun exposure but unrelated to ERK phosphorylation in MODERN PATHOLOGY
  • 2012-02. Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma in NATURE GENETICS
  • 1997-08. Ras effectors and their role in mitogenesis and oncogenesis in JOURNAL OF MOLECULAR MEDICINE
  • 2004-09. Effects of G-protein mutations on skin color in NATURE GENETICS
  • 2009-01. Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi in NATURE
  • 2010-12. COT drives resistance to RAF inhibition through MAP kinase pathway reactivation in NATURE
  • 2010-12. Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation in NATURE
  • 1984-10. A novel transforming gene in a human malignant melanoma cell line in NATURE
  • 2006-01. Examination of Mutations in BRAF, NRAS, and PTEN in Primary Cutaneous Melanoma in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2005-08. BRAF and NRAS Mutations Are Frequent in Nodular Melanoma but Are not Associated with Tumor Cell Proliferation or Patient Survival in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2009-01. Genotypic and Gene Expression Studies in Congenital Melanocytic Nevi: Insight into Initial Steps of Melanotumorigenesis in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2010-02. Methylation of PTEN as a Prognostic Factor in Malignant Melanoma of the Skin in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2005-09. Prevalence of Exon 15 BRAF Mutations in Primary Melanoma of the Superficial Spreading, Nodular, Acral, and Lentigo Maligna Subtypes in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2011-05. Exome sequencing identifies GRIN2A as frequently mutated in melanoma in NATURE GENETICS
  • 2009-05. BrafV600E cooperates with Pten loss to induce metastatic melanoma in NATURE GENETICS
  • 2008-09. Phase II trial of imatinib mesylate in patients with metastatic melanoma in BRITISH JOURNAL OF CANCER
  • 2008-10. A novel AKT3 mutation in melanoma tumours and cell lines in BRITISH JOURNAL OF CANCER
  • 2011-11-13. A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11912-012-0249-5

    DOI

    http://dx.doi.org/10.1007/s11912-012-0249-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1051894542

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22723080


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