Mucosal Melanoma: Pathogenesis, Clinical Behavior, and Management View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-06-04

AUTHORS

Michael A. Postow, Omid Hamid, Richard D. Carvajal

ABSTRACT

Mucosal melanoma represents a rare subtype of melanoma with distinct biological, clinical, and management considerations. Knowledge regarding optimal treatment strategies for mucosal melanoma is limited and based primarily upon small case series and single-institution, retrospective analyses. Surgery remains the standard of care for loco-regional management, but the common presence of multifocal disease and the high rate of distant recurrence should be considered before pursuing aggressive surgical interventions associated with inherent significant morbidity. The role of sentinel lymph node biopsy and lymph node dissection remains unclear. Radiotherapy has not been shown to improve overall survival but may reduce the rate of local recurrence. Significant advances in the treatment of metastatic disease have been made with novel immunotherapeutic agents, the discovery of KIT and BRAF mutations and the development of targeted agents that inhibit these oncogenic pathways. More... »

PAGES

441-448

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11912-012-0244-x

DOI

http://dx.doi.org/10.1007/s11912-012-0244-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010407702

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22661391


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