Ontology type: schema:ScholarlyArticle
2011-12
AUTHORS ABSTRACTPoly(ADP-ribose)polymerase (PARP) inhibitors are showing considerable promise for the treatment of BRCA mutation-associated ovarian and breast cancer. This approach exploits a synthetic lethal strategy to target the specific DNA repair pathway in cancers that harbor mutations in the BRCA1 or BRCA2 genes. Accumulating evidence suggests that PARP inhibitors may have a wider application in the treatment of sporadic, high-grade serous ovarian cancers and other cancers including endometrial cancer. In this review, we discuss the clinical development of PARP inhibitors in ovarian cancer and explore challenges that need to be addressed if the full potential of these agents is to be realized. More... »
PAGES442-449
http://scigraph.springernature.com/pub.10.1007/s11912-011-0193-9
DOIhttp://dx.doi.org/10.1007/s11912-011-0193-9
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1031333294
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/21913063
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antineoplastic Agents",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Enzyme Inhibitors",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Genes, BRCA1",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Genes, BRCA2",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Genetic Predisposition to Disease",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mutation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Ovarian Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Poly(ADP-ribose) Polymerase Inhibitors",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Royal Marsden NHS Foundation Trust",
"id": "https://www.grid.ac/institutes/grid.5072.0",
"name": [
"Gynaecology Unit, The Royal Marsden NHS Foundation Trust, Downs Rd., Sutton, SM2 5PT, Surrey, UK"
],
"type": "Organization"
},
"familyName": "Banerjee",
"givenName": "Susana",
"id": "sg:person.01326353035.21",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326353035.21"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institute of Cancer Research",
"id": "https://www.grid.ac/institutes/grid.18886.3f",
"name": [
"Division of Clinical Studies, Institute of Cancer Research, Drug Development Unit, The Royal Marsden NHS Foundation Trust, Sycamore House Downs Rd., Sutton, SM2 5PT, Surrey, UK"
],
"type": "Organization"
},
"familyName": "Kaye",
"givenName": "Stan",
"id": "sg:person.010545363662.22",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010545363662.22"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1158/1078-0432.ccr-10-1027",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003096597"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1471-2407-8-17",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003338054",
"https://doi.org/10.1186/1471-2407-8-17"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-09-2758",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004183327"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2008.16.0812",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004822762"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ejca.2007.07.010",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007669060"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(10)60893-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010088435"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/mcb.22.2.669-679.2002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017000303"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/emboj/20.17.4704",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017832806"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2009.27.2997",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019125039"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2009.26.9589",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020121676"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2010.29.5352",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021632658"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrclinonc.2010.116",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022428089",
"https://doi.org/10.1038/nrclinonc.2010.116"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrclinonc.2010.116",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022428089",
"https://doi.org/10.1038/nrclinonc.2010.116"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/jama.283.17.2260",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023526030"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/35077232",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027480321",
"https://doi.org/10.1038/35077232"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/35077232",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027480321",
"https://doi.org/10.1038/35077232"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/emmm.200900041",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028475219"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa1011418",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030192747"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00008390-200609001-00149",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030938628"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00008390-200609001-00149",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030938628"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2010.28.3085",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035187064"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa0900212",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036199013"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature03443",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036499081",
"https://doi.org/10.1038/nature03443"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature03443",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036499081",
"https://doi.org/10.1038/nature03443"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature03445",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039649759",
"https://doi.org/10.1038/nature03445"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature03445",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039649759",
"https://doi.org/10.1038/nature03445"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature06548",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040539424",
"https://doi.org/10.1038/nature06548"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc1457",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042257134",
"https://doi.org/10.1038/nrc1457"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc1457",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042257134",
"https://doi.org/10.1038/nrc1457"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2009.27.5719",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043337914"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2008.16.1703",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044514914"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1097-2765(00)80035-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045196719"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-06-3039",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048464268"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.bbrc.2006.09.049",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050939909"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jnci/djh005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052081206"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc1691",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052792626",
"https://doi.org/10.1038/nrc1691"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc1691",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052792626",
"https://doi.org/10.1038/nrc1691"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/scitranslmed.3001538",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062686824"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/scitranslmed.3001538",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062686824"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.20.2.463",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064202762"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3892/ijmm.22.1.113",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071508829"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074674947",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074712901",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2001.19.14.3312",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1074849831"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2010.28.15_suppl.1018",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083942284"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2010.28.15_suppl.3002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083942881"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2011.29.15_suppl.3104",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083947613"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2011.29.15_suppl.5003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083948051"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2011.29.15_suppl.5028",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083948076"
],
"type": "CreativeWork"
}
],
"datePublished": "2011-12",
"datePublishedReg": "2011-12-01",
"description": "Poly(ADP-ribose)polymerase (PARP) inhibitors are showing considerable promise for the treatment of BRCA mutation-associated ovarian and breast cancer. This approach exploits a synthetic lethal strategy to target the specific DNA repair pathway in cancers that harbor mutations in the BRCA1 or BRCA2 genes. Accumulating evidence suggests that PARP inhibitors may have a wider application in the treatment of sporadic, high-grade serous ovarian cancers and other cancers including endometrial cancer. In this review, we discuss the clinical development of PARP inhibitors in ovarian cancer and explore challenges that need to be addressed if the full potential of these agents is to be realized.",
"genre": "research_article",
"id": "sg:pub.10.1007/s11912-011-0193-9",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1021174",
"issn": [
"1523-3790",
"1534-6269"
],
"name": "Current Oncology Reports",
"type": "Periodical"
},
{
"issueNumber": "6",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "13"
}
],
"name": "PARP Inhibitors in BRCA Gene-Mutated Ovarian Cancer and Beyond",
"pagination": "442-449",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"95442571eaa9569a39fdb630f32d606d0bb30e88bd54aa7bf2c9045fec965950"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"21913063"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"100888967"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s11912-011-0193-9"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1031333294"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s11912-011-0193-9",
"https://app.dimensions.ai/details/publication/pub.1031333294"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T15:03",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000522.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1007%2Fs11912-011-0193-9"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11912-011-0193-9'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11912-011-0193-9'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11912-011-0193-9'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11912-011-0193-9'
This table displays all metadata directly associated to this object as RDF triples.
248 TRIPLES
21 PREDICATES
80 URIs
31 LITERALS
19 BLANK NODES