PARP Inhibitors in BRCA Gene-Mutated Ovarian Cancer and Beyond View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-12

AUTHORS

Susana Banerjee, Stan Kaye

ABSTRACT

Poly(ADP-ribose)polymerase (PARP) inhibitors are showing considerable promise for the treatment of BRCA mutation-associated ovarian and breast cancer. This approach exploits a synthetic lethal strategy to target the specific DNA repair pathway in cancers that harbor mutations in the BRCA1 or BRCA2 genes. Accumulating evidence suggests that PARP inhibitors may have a wider application in the treatment of sporadic, high-grade serous ovarian cancers and other cancers including endometrial cancer. In this review, we discuss the clinical development of PARP inhibitors in ovarian cancer and explore challenges that need to be addressed if the full potential of these agents is to be realized. More... »

PAGES

442-449

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11912-011-0193-9

DOI

http://dx.doi.org/10.1007/s11912-011-0193-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031333294

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21913063


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