Imatinib resistance in gastrointestinal stromal tumors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-08

AUTHORS

Lei L. Chen, Mahyar Sabripour, Robert H. I. Andtbacka, Shreyaskumar R. Patel, Barry W. Feig, Homer A. Macapinlac, Haesun Choi, Elsie F. Wu, Marsha L. Frazier, Robert S. Benjamin

ABSTRACT

Conventional chemotherapeutic drugs are ineffective in treatment of gastrointestinal stromal tumors (GISTs). Imatinib (STI571, Gleevec, Glivec; Novartis Pharmaceuticals, East Hanover, NJ), a selective inhibitor of KIT, ABL, BCR-ABL, PDGFRA, and PDGFRB, represents a new paradigm of targeted cancer therapy and has revolutionized the treatment of patients with chronic myelogenous leukemia and GISTs. Unfortunately, imatinib resistance has emerged. The reported mechanism of imatinib resistance in GISTs involves missense mutation in the kinase domain of KIT, including Thr670Ile, Tyr823Asp, and Val654Ala. The established mechanisms and potential mechanisms of imatinib resistance in GISTs, the imaging studies indicative of early development of imatinib resistance, and the management of imatinib-resistant GISTs are discussed. More... »

PAGES

293-299

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11912-005-0053-6

DOI

http://dx.doi.org/10.1007/s11912-005-0053-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044456886

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15946589


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Benzamides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Resistance, Neoplasm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gastrointestinal Stromal Tumors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Imatinib Mesylate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation, Missense", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Piperazines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-kit", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pyrimidines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiography", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Sarcoma, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Lei L.", 
        "id": "sg:person.01353651245.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353651245.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Sarcoma, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sabripour", 
        "givenName": "Mahyar", 
        "id": "sg:person.01346567101.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346567101.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Sarcoma, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Andtbacka", 
        "givenName": "Robert H. I.", 
        "id": "sg:person.014730634504.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014730634504.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Sarcoma, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Patel", 
        "givenName": "Shreyaskumar R.", 
        "id": "sg:person.013307202747.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013307202747.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Sarcoma, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Feig", 
        "givenName": "Barry W.", 
        "id": "sg:person.0634233332.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634233332.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Sarcoma, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Macapinlac", 
        "givenName": "Homer A.", 
        "id": "sg:person.0677650210.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677650210.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Sarcoma, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Choi", 
        "givenName": "Haesun", 
        "id": "sg:person.010525265157.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010525265157.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Sarcoma, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wu", 
        "givenName": "Elsie F.", 
        "id": "sg:person.07533257057.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07533257057.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Sarcoma, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Frazier", 
        "givenName": "Marsha L.", 
        "id": "sg:person.01363632554.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363632554.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Sarcoma, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Benjamin", 
        "givenName": "Robert S.", 
        "id": "sg:person.01200333274.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200333274.18"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/j.1349-7006.2003.tb01439.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008535285"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.2003.tb01439.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008535285"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(04)17098-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012604875"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2004.02.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015864331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m403319200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017400641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.leukres.2003.10.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020322430"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2006.07.3049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020547992"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-04-0085", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020932239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa020461", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022255922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1586/14737140.4.4.595", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030488898"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2005.04.034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031196747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-006-9034-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032109989", 
          "https://doi.org/10.1245/s10434-006-9034-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(20000101)88:1<66::aid-cncr10>3.0.co;2-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033331661"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0016-5085(03)01046-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033354434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0016-5085(03)01046-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033354434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(01)06535-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038004584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0165-4608(02)00546-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038258595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2003.11.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040640515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00062752-200401000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045587978"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00062752-200401000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045587978"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6601819", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046888142", 
          "https://doi.org/10.1038/sj.bjc.6601819"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6601819", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046888142", 
          "https://doi.org/10.1038/sj.bjc.6601819"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.279.5350.577", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049612615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/elps.1150181505", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049714182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/elps.1150181505", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049714182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-8049(02)80599-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053076846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-8049(02)80599-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053076846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1079666", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062447255"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2003.04.190", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074521017", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075344777", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076805158", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.14670/hh-19.565", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076810754"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2005-08", 
    "datePublishedReg": "2005-08-01", 
    "description": "Conventional chemotherapeutic drugs are ineffective in treatment of gastrointestinal stromal tumors (GISTs). Imatinib (STI571, Gleevec, Glivec; Novartis Pharmaceuticals, East Hanover, NJ), a selective inhibitor of KIT, ABL, BCR-ABL, PDGFRA, and PDGFRB, represents a new paradigm of targeted cancer therapy and has revolutionized the treatment of patients with chronic myelogenous leukemia and GISTs. Unfortunately, imatinib resistance has emerged. The reported mechanism of imatinib resistance in GISTs involves missense mutation in the kinase domain of KIT, including Thr670Ile, Tyr823Asp, and Val654Ala. The established mechanisms and potential mechanisms of imatinib resistance in GISTs, the imaging studies indicative of early development of imatinib resistance, and the management of imatinib-resistant GISTs are discussed.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s11912-005-0053-6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2622457", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2688780", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438826", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1021174", 
        "issn": [
          "1523-3790", 
          "1534-6269"
        ], 
        "name": "Current Oncology Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "name": "Imatinib resistance in gastrointestinal stromal tumors", 
    "pagination": "293-299", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "d3c3eb64da4d823fbc8779c9b889f4dad6e19ae98b18d23ef474291346325c6f"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "15946589"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100888967"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11912-005-0053-6"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1044456886"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11912-005-0053-6", 
      "https://app.dimensions.ai/details/publication/pub.1044456886"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T18:23", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8675_00000524.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs11912-005-0053-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11912-005-0053-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11912-005-0053-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11912-005-0053-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11912-005-0053-6'


 

This table displays all metadata directly associated to this object as RDF triples.

262 TRIPLES      21 PREDICATES      67 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11912-005-0053-6 schema:about N0ba8da5ee328452aa7e5f1c85dcbde78
2 N0ceb0716bddd481890276e45a98bfb54
3 N0f289493c26d4ad18daacbe323f7e71b
4 N1f820cf0fc8544e2afeec34e43552c69
5 N47625b326f5b4c718a112c15b80d009f
6 N5a3b9b79eda44273afe33665711a70a9
7 N7d2af5e7eb24416782e19cf9ef8c34b4
8 N9a3fd81d54914270aae3e5df89f3bc76
9 Nc294033bee2149b6a825e74eb91cca1c
10 Nd3412a7e5d7741bb81467c45807fab70
11 Nf44d4169055d48258015a8024b01fcbe
12 anzsrc-for:11
13 anzsrc-for:1112
14 schema:author Nd633ff856a714e92bab6ed972e347925
15 schema:citation sg:pub.10.1038/sj.bjc.6601819
16 sg:pub.10.1245/s10434-006-9034-8
17 https://app.dimensions.ai/details/publication/pub.1074521017
18 https://app.dimensions.ai/details/publication/pub.1075344777
19 https://app.dimensions.ai/details/publication/pub.1076805158
20 https://doi.org/10.1002/(sici)1097-0142(20000101)88:1<66::aid-cncr10>3.0.co;2-0
21 https://doi.org/10.1002/elps.1150181505
22 https://doi.org/10.1016/j.ejca.2003.11.025
23 https://doi.org/10.1016/j.ejca.2005.04.034
24 https://doi.org/10.1016/j.leukres.2003.10.007
25 https://doi.org/10.1016/s0016-5085(03)01046-1
26 https://doi.org/10.1016/s0140-6736(01)06535-7
27 https://doi.org/10.1016/s0140-6736(04)17098-0
28 https://doi.org/10.1016/s0165-4608(02)00546-0
29 https://doi.org/10.1016/s0959-8049(02)80599-8
30 https://doi.org/10.1053/j.gastro.2004.02.021
31 https://doi.org/10.1056/nejmoa020461
32 https://doi.org/10.1074/jbc.m403319200
33 https://doi.org/10.1097/00062752-200401000-00006
34 https://doi.org/10.1111/j.1349-7006.2003.tb01439.x
35 https://doi.org/10.1126/science.1079666
36 https://doi.org/10.1126/science.279.5350.577
37 https://doi.org/10.1158/0008-5472.can-04-0085
38 https://doi.org/10.1200/jco.2003.04.190
39 https://doi.org/10.1200/jco.2006.07.3049
40 https://doi.org/10.14670/hh-19.565
41 https://doi.org/10.1586/14737140.4.4.595
42 schema:datePublished 2005-08
43 schema:datePublishedReg 2005-08-01
44 schema:description Conventional chemotherapeutic drugs are ineffective in treatment of gastrointestinal stromal tumors (GISTs). Imatinib (STI571, Gleevec, Glivec; Novartis Pharmaceuticals, East Hanover, NJ), a selective inhibitor of KIT, ABL, BCR-ABL, PDGFRA, and PDGFRB, represents a new paradigm of targeted cancer therapy and has revolutionized the treatment of patients with chronic myelogenous leukemia and GISTs. Unfortunately, imatinib resistance has emerged. The reported mechanism of imatinib resistance in GISTs involves missense mutation in the kinase domain of KIT, including Thr670Ile, Tyr823Asp, and Val654Ala. The established mechanisms and potential mechanisms of imatinib resistance in GISTs, the imaging studies indicative of early development of imatinib resistance, and the management of imatinib-resistant GISTs are discussed.
45 schema:genre research_article
46 schema:inLanguage en
47 schema:isAccessibleForFree false
48 schema:isPartOf Nbd3e6aab5403487880261e5c8b595a43
49 Nddd76019214e499eba5af670a15d0e18
50 sg:journal.1021174
51 schema:name Imatinib resistance in gastrointestinal stromal tumors
52 schema:pagination 293-299
53 schema:productId N13e9d23b623248068744127fc065440f
54 N6a1dbd22789e4a09a2b64ba19658bf51
55 N832e3a8f13da43668b36ad66fa782b9b
56 Nc406d1f74a5d4c7fa2450e1d51f9f2bc
57 Nd6cb7bc0356542a78dc70afe111c29ee
58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044456886
59 https://doi.org/10.1007/s11912-005-0053-6
60 schema:sdDatePublished 2019-04-10T18:23
61 schema:sdLicense https://scigraph.springernature.com/explorer/license/
62 schema:sdPublisher Na749378a9ef04c91864ff67d0ee34dea
63 schema:url http://link.springer.com/10.1007%2Fs11912-005-0053-6
64 sgo:license sg:explorer/license/
65 sgo:sdDataset articles
66 rdf:type schema:ScholarlyArticle
67 N04a4574e0b984b97a4a0c184306168a1 rdf:first sg:person.01363632554.96
68 rdf:rest N93791340b6384f5e844168807739c581
69 N0ba8da5ee328452aa7e5f1c85dcbde78 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
70 schema:name Proto-Oncogene Proteins c-kit
71 rdf:type schema:DefinedTerm
72 N0ceb0716bddd481890276e45a98bfb54 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Gastrointestinal Stromal Tumors
74 rdf:type schema:DefinedTerm
75 N0f289493c26d4ad18daacbe323f7e71b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Radiography
77 rdf:type schema:DefinedTerm
78 N13e9d23b623248068744127fc065440f schema:name nlm_unique_id
79 schema:value 100888967
80 rdf:type schema:PropertyValue
81 N1f820cf0fc8544e2afeec34e43552c69 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Imatinib Mesylate
83 rdf:type schema:DefinedTerm
84 N47625b326f5b4c718a112c15b80d009f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Benzamides
86 rdf:type schema:DefinedTerm
87 N4b50c7e456b24e93921cf1bfa0765db1 rdf:first sg:person.0677650210.40
88 rdf:rest Ne68871234f9041ff926d783ea0d86bba
89 N55753e30022a4d76a6d7e4e1247bfd4b rdf:first sg:person.013307202747.74
90 rdf:rest N76ccc2b374db47c4a4642a850413428c
91 N5a3b9b79eda44273afe33665711a70a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Pyrimidines
93 rdf:type schema:DefinedTerm
94 N63917f7cd05c40d88a11aae433684c62 rdf:first sg:person.014730634504.19
95 rdf:rest N55753e30022a4d76a6d7e4e1247bfd4b
96 N6a1dbd22789e4a09a2b64ba19658bf51 schema:name dimensions_id
97 schema:value pub.1044456886
98 rdf:type schema:PropertyValue
99 N6d1a4b4bf07345bf926b4a763ec3bada rdf:first sg:person.01346567101.03
100 rdf:rest N63917f7cd05c40d88a11aae433684c62
101 N76ccc2b374db47c4a4642a850413428c rdf:first sg:person.0634233332.35
102 rdf:rest N4b50c7e456b24e93921cf1bfa0765db1
103 N7d2af5e7eb24416782e19cf9ef8c34b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Piperazines
105 rdf:type schema:DefinedTerm
106 N832e3a8f13da43668b36ad66fa782b9b schema:name readcube_id
107 schema:value d3c3eb64da4d823fbc8779c9b889f4dad6e19ae98b18d23ef474291346325c6f
108 rdf:type schema:PropertyValue
109 N93791340b6384f5e844168807739c581 rdf:first sg:person.01200333274.18
110 rdf:rest rdf:nil
111 N9a3fd81d54914270aae3e5df89f3bc76 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Drug Resistance, Neoplasm
113 rdf:type schema:DefinedTerm
114 Na749378a9ef04c91864ff67d0ee34dea schema:name Springer Nature - SN SciGraph project
115 rdf:type schema:Organization
116 Nb7460e2f67d241c8beabf413630d9fc9 rdf:first sg:person.07533257057.42
117 rdf:rest N04a4574e0b984b97a4a0c184306168a1
118 Nbd3e6aab5403487880261e5c8b595a43 schema:volumeNumber 7
119 rdf:type schema:PublicationVolume
120 Nc294033bee2149b6a825e74eb91cca1c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Mutation, Missense
122 rdf:type schema:DefinedTerm
123 Nc406d1f74a5d4c7fa2450e1d51f9f2bc schema:name pubmed_id
124 schema:value 15946589
125 rdf:type schema:PropertyValue
126 Nd3412a7e5d7741bb81467c45807fab70 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Antineoplastic Agents
128 rdf:type schema:DefinedTerm
129 Nd633ff856a714e92bab6ed972e347925 rdf:first sg:person.01353651245.12
130 rdf:rest N6d1a4b4bf07345bf926b4a763ec3bada
131 Nd6cb7bc0356542a78dc70afe111c29ee schema:name doi
132 schema:value 10.1007/s11912-005-0053-6
133 rdf:type schema:PropertyValue
134 Nddd76019214e499eba5af670a15d0e18 schema:issueNumber 4
135 rdf:type schema:PublicationIssue
136 Ne68871234f9041ff926d783ea0d86bba rdf:first sg:person.010525265157.54
137 rdf:rest Nb7460e2f67d241c8beabf413630d9fc9
138 Nf44d4169055d48258015a8024b01fcbe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Humans
140 rdf:type schema:DefinedTerm
141 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
142 schema:name Medical and Health Sciences
143 rdf:type schema:DefinedTerm
144 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
145 schema:name Oncology and Carcinogenesis
146 rdf:type schema:DefinedTerm
147 sg:grant.2438826 http://pending.schema.org/fundedItem sg:pub.10.1007/s11912-005-0053-6
148 rdf:type schema:MonetaryGrant
149 sg:grant.2622457 http://pending.schema.org/fundedItem sg:pub.10.1007/s11912-005-0053-6
150 rdf:type schema:MonetaryGrant
151 sg:grant.2688780 http://pending.schema.org/fundedItem sg:pub.10.1007/s11912-005-0053-6
152 rdf:type schema:MonetaryGrant
153 sg:journal.1021174 schema:issn 1523-3790
154 1534-6269
155 schema:name Current Oncology Reports
156 rdf:type schema:Periodical
157 sg:person.010525265157.54 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
158 schema:familyName Choi
159 schema:givenName Haesun
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010525265157.54
161 rdf:type schema:Person
162 sg:person.01200333274.18 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
163 schema:familyName Benjamin
164 schema:givenName Robert S.
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200333274.18
166 rdf:type schema:Person
167 sg:person.013307202747.74 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
168 schema:familyName Patel
169 schema:givenName Shreyaskumar R.
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013307202747.74
171 rdf:type schema:Person
172 sg:person.01346567101.03 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
173 schema:familyName Sabripour
174 schema:givenName Mahyar
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346567101.03
176 rdf:type schema:Person
177 sg:person.01353651245.12 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
178 schema:familyName Chen
179 schema:givenName Lei L.
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353651245.12
181 rdf:type schema:Person
182 sg:person.01363632554.96 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
183 schema:familyName Frazier
184 schema:givenName Marsha L.
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363632554.96
186 rdf:type schema:Person
187 sg:person.014730634504.19 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
188 schema:familyName Andtbacka
189 schema:givenName Robert H. I.
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014730634504.19
191 rdf:type schema:Person
192 sg:person.0634233332.35 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
193 schema:familyName Feig
194 schema:givenName Barry W.
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634233332.35
196 rdf:type schema:Person
197 sg:person.0677650210.40 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
198 schema:familyName Macapinlac
199 schema:givenName Homer A.
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677650210.40
201 rdf:type schema:Person
202 sg:person.07533257057.42 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
203 schema:familyName Wu
204 schema:givenName Elsie F.
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07533257057.42
206 rdf:type schema:Person
207 sg:pub.10.1038/sj.bjc.6601819 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046888142
208 https://doi.org/10.1038/sj.bjc.6601819
209 rdf:type schema:CreativeWork
210 sg:pub.10.1245/s10434-006-9034-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032109989
211 https://doi.org/10.1245/s10434-006-9034-8
212 rdf:type schema:CreativeWork
213 https://app.dimensions.ai/details/publication/pub.1074521017 schema:CreativeWork
214 https://app.dimensions.ai/details/publication/pub.1075344777 schema:CreativeWork
215 https://app.dimensions.ai/details/publication/pub.1076805158 schema:CreativeWork
216 https://doi.org/10.1002/(sici)1097-0142(20000101)88:1<66::aid-cncr10>3.0.co;2-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033331661
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1002/elps.1150181505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049714182
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1016/j.ejca.2003.11.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040640515
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1016/j.ejca.2005.04.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031196747
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1016/j.leukres.2003.10.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020322430
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/s0016-5085(03)01046-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033354434
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/s0140-6736(01)06535-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038004584
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/s0140-6736(04)17098-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012604875
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/s0165-4608(02)00546-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038258595
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/s0959-8049(02)80599-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053076846
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1053/j.gastro.2004.02.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015864331
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1056/nejmoa020461 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022255922
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1074/jbc.m403319200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017400641
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1097/00062752-200401000-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045587978
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1111/j.1349-7006.2003.tb01439.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008535285
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1126/science.1079666 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062447255
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1126/science.279.5350.577 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049612615
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1158/0008-5472.can-04-0085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020932239
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1200/jco.2003.04.190 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203567
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1200/jco.2006.07.3049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020547992
255 rdf:type schema:CreativeWork
256 https://doi.org/10.14670/hh-19.565 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076810754
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1586/14737140.4.4.595 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030488898
259 rdf:type schema:CreativeWork
260 https://www.grid.ac/institutes/grid.240145.6 schema:alternateName The University of Texas MD Anderson Cancer Center
261 schema:name Department of Sarcoma, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, TX, USA
262 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...