Chemotherapy-Related Neurotoxicity View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-09

AUTHORS

Sophie Taillibert, Emilie Le Rhun, Marc C. Chamberlain

ABSTRACT

Chemotherapy may have detrimental effects on either the central or peripheral nervous system. Central nervous system neurotoxicity resulting from chemotherapy manifests as a wide range of clinical syndromes including acute, subacute, and chronic encephalopathies, posterior reversible encephalopathy, acute cerebellar dysfunction, chronic cognitive impairment, myelopathy, meningitis, and neurovascular syndromes. These clinical entities vary by causative agent, degree of severity, evolution, and timing of occurrence. In the peripheral nervous system, chemotherapy-induced peripheral neuropathy (CIPN) and myopathy are the two main complications of chemotherapy. CIPN is the most common complication, and the majority manifest as a dose-dependent length-dependent sensory axonopathy. In severe cases of CIPN, the dose of chemotherapy is reduced, the administration delayed, or the treatment discontinued. Few treatments are available for CIPN and based on meta-analysis, duloxetine is the preferred symptomatic treatment. Myopathy due to corticosteroid use is the most frequent cause of muscle disorders in patients with cancer. More... »

PAGES

81

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11910-016-0686-x

    DOI

    http://dx.doi.org/10.1007/s11910-016-0686-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1019118347

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27443648


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