Prion-like Mechanisms in the Pathogenesis of Tauopathies and Synucleinopathies View Full Text


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Article Info

DATE

2014-09-14

AUTHORS

Michel Goedert, Ben Falcon, Florence Clavaguera, Markus Tolnay

ABSTRACT

Neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease, are characterized by the abnormal aggregation of a small number of intracellular proteins, with tau and α-synuclein being the most commonly affected. Until recently, the events leading to aggregate formation were believed to be entirely cell-autonomous, with protein misfolding occurring independently in many cells. It is now believed that protein aggregates form in a small number of brain cells, from which they propagate intercellularly through templated recruitment, reminiscent of the mechanisms by which prions spread through the nervous system. More... »

PAGES

495

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11910-014-0495-z

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    http://dx.doi.org/10.1007/s11910-014-0495-z

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    PUBMED

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