Radiation Necrosis: Relevance with Respect to Treatment of Primary and Secondary Brain Tumors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-06

AUTHORS

James Fink, Donald Born, Marc C. Chamberlain

ABSTRACT

Radiation injury to the central nervous system (CNS) manifests in multiple forms and is divided into three categories termed acute, early-delayed, and late-delayed injury patterns. Late-delayed radiation injury, primarily manifesting as leukoencephalopathy or radiation necrosis, is often progressive and may have a negative impact on quality of life. Radiation injury is believed to be a consequence of cell membrane and DNA injury with a pathological expression as vascular injury, depletion of oligodendroglial progenitor cells, and failure of cell-cell interactions that constitute the cellular network of the CNS. In addition, radiation injury results in activation of the inflammatory cascade with perturbation of cytokines, production of reactive oxygen species and vascular endothelial growth factor. Medical treatment of CNS radiation injury and in particular radiation necrosis remains problematic as there is a paucity of clinical trial data to inform treatment decisions, and aside from surgery and corticosteroids only bevacizumab appears to have a compelling therapeutic role. More... »

PAGES

276-285

References to SciGraph publications

  • 2001-11. Radiation induced CNS toxicity – molecular and cellular mechanisms in BRITISH JOURNAL OF CANCER
  • 2008-05. Mechanisms of radiation-induced brain toxicity and implications for future clinical trials in JOURNAL OF NEURO-ONCOLOGY
  • 2011-09. Pseudoprogression: Relevance With Respect to Treatment of High-Grade Gliomas in CURRENT TREATMENT OPTIONS IN ONCOLOGY
  • 1974-10. Neuroglial cells in the cerebral cortex of rats from young adulthood to old age: An electron microscope study in BRAIN CELL BIOLOGY
  • 1983-06. A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium in NATURE
  • 2007-03. Early necrosis following concurrent Temodar and radiotherapy in patients with glioblastoma in JOURNAL OF NEURO-ONCOLOGY
  • 2002-05. Astroglia induce neurogenesis from adult neural stem cells in NATURE
  • 1982-03. Late vascular effects of whole brain X-irradiation in the mouse in ACTA NEUROCHIRURGICA
  • 2008-08. VEGF-targeted therapy: mechanisms of anti-tumour activity in NATURE REVIEWS CANCER
  • 1984-09. Effects of radiotherapy on the astrocytomatous areas of malignant gliomas in JOURNAL OF NEURO-ONCOLOGY
  • 2008-11. Pathological review of late cerebral radionecrosis in BRAIN TUMOR PATHOLOGY
  • 2009-08. Initial experience with bevacizumab treatment for biopsy confirmed cerebral radiation necrosis in JOURNAL OF NEURO-ONCOLOGY
  • 1987-01. Astrocytes induce blood–brain barrier properties in endothelial cells in NATURE
  • 2006-03. Cancer therapy-associated CNS neuropathology: an update and review of the literature in ACTA NEUROPATHOLOGICA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11910-012-0258-7

    DOI

    http://dx.doi.org/10.1007/s11910-012-0258-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1024000095

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22350279


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Neurosciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Brain Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cytokines", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Necrosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neuroimaging", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Radiation Injuries", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Reactive Oxygen Species", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Time Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Vascular Endothelial Growth Factor A", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Washington University in St. Louis", 
              "id": "https://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Department of Radiology, University of Washington, St. Louis, MO, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fink", 
            "givenName": "James", 
            "id": "sg:person.0765030013.80", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765030013.80"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Washington", 
              "id": "https://www.grid.ac/institutes/grid.34477.33", 
              "name": [
                "Department of Pathology, University of Washington, Seattle, WA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Born", 
            "givenName": "Donald", 
            "id": "sg:person.01013752502.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013752502.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Washington", 
              "id": "https://www.grid.ac/institutes/grid.34477.33", 
              "name": [
                "Department of Neurology and Neurosurgery, University of Washington/Fred Hutchinson Cancer Center, 825 Eastlake Ave E, MS: G4-940, 98109, Seattle, WA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chamberlain", 
            "givenName": "Marc C.", 
            "id": "sg:person.01326261166.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326261166.36"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1002/1097-0142(197007)26:1<138::aid-cncr2820260117>3.0.co;2-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000552119"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00043426-200404000-00008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000644995"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00043426-200404000-00008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000644995"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00043426-200404000-00008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000644995"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2008.19.4969", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001994504"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0165-0173(92)90007-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002119543"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0165-0173(92)90007-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002119543"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01405622", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002258513", 
              "https://doi.org/10.1007/bf01405622"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01405622", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002258513", 
              "https://doi.org/10.1007/bf01405622"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1097-0142(197410)34:4<1069::aid-cncr2820340416>3.0.co;2-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002522789"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0022-510x(03)00007-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002612082"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1471-4159.1999.0722334.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002910484"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(08)70125-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004307323"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2147/cmar.s6103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006669760"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0163-7258(94)00047-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007376525"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-0142(19971115)80:10<2005::aid-cncr19>3.0.co;2-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007563519"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/417039a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009958221", 
              "https://doi.org/10.1038/417039a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/417039a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009958221", 
              "https://doi.org/10.1038/417039a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1148/radiology.217.2.r00nv36377", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010183767"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1750-3639.1999.tb00212.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011931168"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/09553009314450861", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012996607"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-03-0426", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015510638"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0360-3016(93)90146-m", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015907714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11060-006-9241-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015983460", 
              "https://doi.org/10.1007/s11060-006-9241-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.274.49.34884", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016634355"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0167-8140(91)90125-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017489032"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0167-8140(91)90125-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017489032"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ijrobp.2006.10.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018013326"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-005-0023-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019017045", 
              "https://doi.org/10.1007/s00401-005-0023-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-005-0023-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019017045", 
              "https://doi.org/10.1007/s00401-005-0023-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0014-5793(99)00451-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019091917"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000056426", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019506637"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.21865", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020123350"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/325253a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020634435", 
              "https://doi.org/10.1038/325253a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2403", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020862106", 
              "https://doi.org/10.1038/nrc2403"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00005072-199906000-00006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021102589"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cncr.23562", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024262815"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10014-008-0233-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025228341", 
              "https://doi.org/10.1007/s10014-008-0233-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10014-008-0233-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025228341", 
              "https://doi.org/10.1007/s10014-008-0233-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0009-9260(69)80043-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027321172"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0360-3016(96)00239-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028651812"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.nrl.0000080951.78533.c4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031470115"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.nrl.0000080951.78533.c4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031470115"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0301-0082(98)00083-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033274977"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/glia.440120306", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036678561"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1097-0142(197606)37:6<2580::aid-cncr2820370603>3.0.co;2-h", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037750522"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1054/bjoc.2001.2100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038082325", 
              "https://doi.org/10.1054/bjoc.2001.2100"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0360-3016(88)90046-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038708752"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0360-3016(80)90175-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040231977"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ijrobp.2009.12.061", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040332699"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1139/y97-146", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040388797"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1091/mbc.10.4.907", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040680649"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci8218", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040876780"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11060-009-9801-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041331134", 
              "https://doi.org/10.1007/s11060-009-9801-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11060-008-9520-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041842515", 
              "https://doi.org/10.1007/s11060-008-9520-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1097-0142(197908)44:2<473::aid-cncr2820440215>3.0.co;2-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043109333"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2009.26.3541", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043187529"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00253268", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043799871", 
              "https://doi.org/10.1007/bf00253268"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00253268", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043799871", 
              "https://doi.org/10.1007/bf00253268"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0090-3019(84)90397-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044712875"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2008.19.1866", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045797441"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0360-3016(90)90440-u", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046000035"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/303390a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046522629", 
              "https://doi.org/10.1038/303390a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11864-011-0157-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047348354", 
              "https://doi.org/10.1007/s11864-011-0157-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0360-3016(90)90264-k", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047551059"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/glia.440140203", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047828948"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01098730", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049215951", 
              "https://doi.org/10.1007/bf01098730"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01098730", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049215951", 
              "https://doi.org/10.1007/bf01098730"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.clineuro.2010.05.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049563534"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1432-1327.2000.01597.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049888793"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0301-0082(88)90008-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050341536"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0301-0082(88)90008-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050341536"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0360-3016(81)90443-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052412908"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-04-1272", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052947120"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0167-8140(93)90174-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053620326"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0167-8140(93)90174-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053620326"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/99.1.101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059444880"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2005.06.081", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064204278"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.wnl.0000133398.11870.9a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064346212"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.wnl.0000133398.11870.9a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064346212"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.wnl.0000133398.11870.9a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064346212"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e31821d74e7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064356197"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e31821d74e7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064356197"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e31821d74e7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064356197"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.44.11.2020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064372131"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1227/00006123-199411000-00004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064433258"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1259/0007-1285-54-648-1081", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064553752"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1259/0007-1285-61-731-1043", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064557258"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1259/0007-1285-65-777-737", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064558818"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1667/0033-7587(2000)153[0357:trotcn]2.0.co;2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1068194327"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2307/3578068", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1070380636"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2307/3579462", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1070381857"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3171/jns.1977.47.3.0336", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071091256"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3171/jns.1977.47.3.0336", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071091256"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3171/jns.1977.47.3.0336", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071091256"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3171/jns.1979.50.5.0624", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071091793"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3171/jns.1979.50.5.0624", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071091793"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3171/jns.1979.50.5.0624", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071091793"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3171/jns.1987.66.1.0001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071094539"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3171/jns.1987.66.1.0001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071094539"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3171/jns.1987.66.1.0001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071094539"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpcell.1999.276.4.c812", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074356972"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpheart.2001.280.1.h434", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074739955"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074801127", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076166518", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077978740", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.09-12-04416.1989", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078906793"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079782969", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082389319", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpcell.1996.271.6.c1973", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083032058"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083224351", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2012-06", 
        "datePublishedReg": "2012-06-01", 
        "description": "Radiation injury to the central nervous system (CNS) manifests in multiple forms and is divided into three categories termed acute, early-delayed, and late-delayed injury patterns. Late-delayed radiation injury, primarily manifesting as leukoencephalopathy or radiation necrosis, is often progressive and may have a negative impact on quality of life. Radiation injury is believed to be a consequence of cell membrane and DNA injury with a pathological expression as vascular injury, depletion of oligodendroglial progenitor cells, and failure of cell-cell interactions that constitute the cellular network of the CNS. In addition, radiation injury results in activation of the inflammatory cascade with perturbation of cytokines, production of reactive oxygen species and vascular endothelial growth factor. Medical treatment of CNS radiation injury and in particular radiation necrosis remains problematic as there is a paucity of clinical trial data to inform treatment decisions, and aside from surgery and corticosteroids only bevacizumab appears to have a compelling therapeutic role.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s11910-012-0258-7", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1022522", 
            "issn": [
              "1528-4042", 
              "1534-6293"
            ], 
            "name": "Current Neurology and Neuroscience Reports", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "3", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "12"
          }
        ], 
        "name": "Radiation Necrosis: Relevance with Respect to Treatment of Primary and Secondary Brain Tumors", 
        "pagination": "276-285", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "725705cc6a90c412305ab7a7a684d61d3a8d988352e8f5ac1302897619500ffd"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "22350279"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "100931790"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s11910-012-0258-7"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1024000095"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s11910-012-0258-7", 
          "https://app.dimensions.ai/details/publication/pub.1024000095"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T14:12", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000522.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007%2Fs11910-012-0258-7"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11910-012-0258-7'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11910-012-0258-7'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11910-012-0258-7'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11910-012-0258-7'


     

    This table displays all metadata directly associated to this object as RDF triples.

    399 TRIPLES      21 PREDICATES      127 URIs      31 LITERALS      19 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s11910-012-0258-7 schema:about N0d3b56cb527d4d0999d2623e9f36a899
    2 N4cbcf0bcb0144e059e5c622de4d32517
    3 N5efde5b7555d430a8a90be88ef5f23b7
    4 N6c82ca01a91b4e7bad50deacfd7259df
    5 N751f99259cdd49d587a45b07c343e2af
    6 Na0b6ad2ae33f4f60bc50c03783d8e3e0
    7 Nb9f0bac43096467e9db19e5c1ab88fe1
    8 Ncd9ad535bb124cec8e52832b1c614fc9
    9 Ne9db58872c92447385664141815412d2
    10 Nea938f55dd7844ad9e5e6bde08d5af23
    11 anzsrc-for:11
    12 anzsrc-for:1109
    13 schema:author N3f252e453ac240cca85e11785035264f
    14 schema:citation sg:pub.10.1007/bf00253268
    15 sg:pub.10.1007/bf01098730
    16 sg:pub.10.1007/bf01405622
    17 sg:pub.10.1007/s00401-005-0023-y
    18 sg:pub.10.1007/s10014-008-0233-9
    19 sg:pub.10.1007/s11060-006-9241-y
    20 sg:pub.10.1007/s11060-008-9520-x
    21 sg:pub.10.1007/s11060-009-9801-z
    22 sg:pub.10.1007/s11864-011-0157-1
    23 sg:pub.10.1038/303390a0
    24 sg:pub.10.1038/325253a0
    25 sg:pub.10.1038/417039a
    26 sg:pub.10.1038/nrc2403
    27 sg:pub.10.1054/bjoc.2001.2100
    28 https://app.dimensions.ai/details/publication/pub.1074801127
    29 https://app.dimensions.ai/details/publication/pub.1076166518
    30 https://app.dimensions.ai/details/publication/pub.1077978740
    31 https://app.dimensions.ai/details/publication/pub.1079782969
    32 https://app.dimensions.ai/details/publication/pub.1082389319
    33 https://app.dimensions.ai/details/publication/pub.1083224351
    34 https://doi.org/10.1002/(sici)1097-0142(19971115)80:10<2005::aid-cncr19>3.0.co;2-0
    35 https://doi.org/10.1002/1097-0142(197007)26:1<138::aid-cncr2820260117>3.0.co;2-5
    36 https://doi.org/10.1002/1097-0142(197410)34:4<1069::aid-cncr2820340416>3.0.co;2-4
    37 https://doi.org/10.1002/1097-0142(197606)37:6<2580::aid-cncr2820370603>3.0.co;2-h
    38 https://doi.org/10.1002/1097-0142(197908)44:2<473::aid-cncr2820440215>3.0.co;2-5
    39 https://doi.org/10.1002/cncr.23562
    40 https://doi.org/10.1002/glia.440120306
    41 https://doi.org/10.1002/glia.440140203
    42 https://doi.org/10.1002/ijc.21865
    43 https://doi.org/10.1016/0090-3019(84)90397-5
    44 https://doi.org/10.1016/0163-7258(94)00047-7
    45 https://doi.org/10.1016/0165-0173(92)90007-9
    46 https://doi.org/10.1016/0167-8140(91)90125-z
    47 https://doi.org/10.1016/0167-8140(93)90174-7
    48 https://doi.org/10.1016/0301-0082(88)90008-1
    49 https://doi.org/10.1016/0360-3016(80)90175-3
    50 https://doi.org/10.1016/0360-3016(81)90443-0
    51 https://doi.org/10.1016/0360-3016(88)90046-6
    52 https://doi.org/10.1016/0360-3016(90)90264-k
    53 https://doi.org/10.1016/0360-3016(90)90440-u
    54 https://doi.org/10.1016/0360-3016(93)90146-m
    55 https://doi.org/10.1016/j.clineuro.2010.05.003
    56 https://doi.org/10.1016/j.ijrobp.2006.10.010
    57 https://doi.org/10.1016/j.ijrobp.2009.12.061
    58 https://doi.org/10.1016/s0009-9260(69)80043-7
    59 https://doi.org/10.1016/s0014-5793(99)00451-2
    60 https://doi.org/10.1016/s0022-510x(03)00007-8
    61 https://doi.org/10.1016/s0301-0082(98)00083-5
    62 https://doi.org/10.1016/s0360-3016(96)00239-8
    63 https://doi.org/10.1016/s1470-2045(08)70125-6
    64 https://doi.org/10.1046/j.1432-1327.2000.01597.x
    65 https://doi.org/10.1046/j.1471-4159.1999.0722334.x
    66 https://doi.org/10.1074/jbc.274.49.34884
    67 https://doi.org/10.1080/09553009314450861
    68 https://doi.org/10.1091/mbc.10.4.907
    69 https://doi.org/10.1093/brain/99.1.101
    70 https://doi.org/10.1097/00005072-199906000-00006
    71 https://doi.org/10.1097/00043426-200404000-00008
    72 https://doi.org/10.1097/01.nrl.0000080951.78533.c4
    73 https://doi.org/10.1111/j.1750-3639.1999.tb00212.x
    74 https://doi.org/10.1139/y97-146
    75 https://doi.org/10.1148/radiology.217.2.r00nv36377
    76 https://doi.org/10.1152/ajpcell.1996.271.6.c1973
    77 https://doi.org/10.1152/ajpcell.1999.276.4.c812
    78 https://doi.org/10.1152/ajpheart.2001.280.1.h434
    79 https://doi.org/10.1158/0008-5472.can-04-1272
    80 https://doi.org/10.1158/1078-0432.ccr-03-0426
    81 https://doi.org/10.1159/000056426
    82 https://doi.org/10.1172/jci8218
    83 https://doi.org/10.1200/jco.2005.06.081
    84 https://doi.org/10.1200/jco.2008.19.1866
    85 https://doi.org/10.1200/jco.2008.19.4969
    86 https://doi.org/10.1200/jco.2009.26.3541
    87 https://doi.org/10.1212/01.wnl.0000133398.11870.9a
    88 https://doi.org/10.1212/wnl.0b013e31821d74e7
    89 https://doi.org/10.1212/wnl.44.11.2020
    90 https://doi.org/10.1227/00006123-199411000-00004
    91 https://doi.org/10.1259/0007-1285-54-648-1081
    92 https://doi.org/10.1259/0007-1285-61-731-1043
    93 https://doi.org/10.1259/0007-1285-65-777-737
    94 https://doi.org/10.1523/jneurosci.09-12-04416.1989
    95 https://doi.org/10.1667/0033-7587(2000)153[0357:trotcn]2.0.co;2
    96 https://doi.org/10.2147/cmar.s6103
    97 https://doi.org/10.2307/3578068
    98 https://doi.org/10.2307/3579462
    99 https://doi.org/10.3171/jns.1977.47.3.0336
    100 https://doi.org/10.3171/jns.1979.50.5.0624
    101 https://doi.org/10.3171/jns.1987.66.1.0001
    102 schema:datePublished 2012-06
    103 schema:datePublishedReg 2012-06-01
    104 schema:description Radiation injury to the central nervous system (CNS) manifests in multiple forms and is divided into three categories termed acute, early-delayed, and late-delayed injury patterns. Late-delayed radiation injury, primarily manifesting as leukoencephalopathy or radiation necrosis, is often progressive and may have a negative impact on quality of life. Radiation injury is believed to be a consequence of cell membrane and DNA injury with a pathological expression as vascular injury, depletion of oligodendroglial progenitor cells, and failure of cell-cell interactions that constitute the cellular network of the CNS. In addition, radiation injury results in activation of the inflammatory cascade with perturbation of cytokines, production of reactive oxygen species and vascular endothelial growth factor. Medical treatment of CNS radiation injury and in particular radiation necrosis remains problematic as there is a paucity of clinical trial data to inform treatment decisions, and aside from surgery and corticosteroids only bevacizumab appears to have a compelling therapeutic role.
    105 schema:genre research_article
    106 schema:inLanguage en
    107 schema:isAccessibleForFree false
    108 schema:isPartOf N34823bf820194c7ebf68fbb9d1e77d48
    109 Nd13e752e52504efb979edd4c724917e8
    110 sg:journal.1022522
    111 schema:name Radiation Necrosis: Relevance with Respect to Treatment of Primary and Secondary Brain Tumors
    112 schema:pagination 276-285
    113 schema:productId N18b269e248b749fdaedc28a84b392d96
    114 N1f6ddcd41df047e9b1f4d1715df79f7f
    115 N4a44235a9e3947d89fcd584f74955a5a
    116 N8c23ee23bfaa49039663b2cb8251d860
    117 Nae09523e22b04d2482837fc5bc77ae3a
    118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024000095
    119 https://doi.org/10.1007/s11910-012-0258-7
    120 schema:sdDatePublished 2019-04-10T14:12
    121 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    122 schema:sdPublisher Na254b823bb1a417781b6df9cb7e1f30a
    123 schema:url http://link.springer.com/10.1007%2Fs11910-012-0258-7
    124 sgo:license sg:explorer/license/
    125 sgo:sdDataset articles
    126 rdf:type schema:ScholarlyArticle
    127 N0d3b56cb527d4d0999d2623e9f36a899 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Cytokines
    129 rdf:type schema:DefinedTerm
    130 N18b269e248b749fdaedc28a84b392d96 schema:name readcube_id
    131 schema:value 725705cc6a90c412305ab7a7a684d61d3a8d988352e8f5ac1302897619500ffd
    132 rdf:type schema:PropertyValue
    133 N1f6ddcd41df047e9b1f4d1715df79f7f schema:name nlm_unique_id
    134 schema:value 100931790
    135 rdf:type schema:PropertyValue
    136 N34823bf820194c7ebf68fbb9d1e77d48 schema:volumeNumber 12
    137 rdf:type schema:PublicationVolume
    138 N3f252e453ac240cca85e11785035264f rdf:first sg:person.0765030013.80
    139 rdf:rest N7ab6876ed6b54c55a7624fb754e0dca9
    140 N4a44235a9e3947d89fcd584f74955a5a schema:name dimensions_id
    141 schema:value pub.1024000095
    142 rdf:type schema:PropertyValue
    143 N4cbcf0bcb0144e059e5c622de4d32517 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Animals
    145 rdf:type schema:DefinedTerm
    146 N5efde5b7555d430a8a90be88ef5f23b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Neuroimaging
    148 rdf:type schema:DefinedTerm
    149 N6c82ca01a91b4e7bad50deacfd7259df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Time Factors
    151 rdf:type schema:DefinedTerm
    152 N751f99259cdd49d587a45b07c343e2af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Reactive Oxygen Species
    154 rdf:type schema:DefinedTerm
    155 N7ab6876ed6b54c55a7624fb754e0dca9 rdf:first sg:person.01013752502.14
    156 rdf:rest N8206087ae55740d19a9a5718867b600e
    157 N8206087ae55740d19a9a5718867b600e rdf:first sg:person.01326261166.36
    158 rdf:rest rdf:nil
    159 N8c23ee23bfaa49039663b2cb8251d860 schema:name pubmed_id
    160 schema:value 22350279
    161 rdf:type schema:PropertyValue
    162 Na0b6ad2ae33f4f60bc50c03783d8e3e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Vascular Endothelial Growth Factor A
    164 rdf:type schema:DefinedTerm
    165 Na254b823bb1a417781b6df9cb7e1f30a schema:name Springer Nature - SN SciGraph project
    166 rdf:type schema:Organization
    167 Nae09523e22b04d2482837fc5bc77ae3a schema:name doi
    168 schema:value 10.1007/s11910-012-0258-7
    169 rdf:type schema:PropertyValue
    170 Nb9f0bac43096467e9db19e5c1ab88fe1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    171 schema:name Brain Neoplasms
    172 rdf:type schema:DefinedTerm
    173 Ncd9ad535bb124cec8e52832b1c614fc9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    174 schema:name Necrosis
    175 rdf:type schema:DefinedTerm
    176 Nd13e752e52504efb979edd4c724917e8 schema:issueNumber 3
    177 rdf:type schema:PublicationIssue
    178 Ne9db58872c92447385664141815412d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    179 schema:name Radiation Injuries
    180 rdf:type schema:DefinedTerm
    181 Nea938f55dd7844ad9e5e6bde08d5af23 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    182 schema:name Humans
    183 rdf:type schema:DefinedTerm
    184 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    185 schema:name Medical and Health Sciences
    186 rdf:type schema:DefinedTerm
    187 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
    188 schema:name Neurosciences
    189 rdf:type schema:DefinedTerm
    190 sg:journal.1022522 schema:issn 1528-4042
    191 1534-6293
    192 schema:name Current Neurology and Neuroscience Reports
    193 rdf:type schema:Periodical
    194 sg:person.01013752502.14 schema:affiliation https://www.grid.ac/institutes/grid.34477.33
    195 schema:familyName Born
    196 schema:givenName Donald
    197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013752502.14
    198 rdf:type schema:Person
    199 sg:person.01326261166.36 schema:affiliation https://www.grid.ac/institutes/grid.34477.33
    200 schema:familyName Chamberlain
    201 schema:givenName Marc C.
    202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326261166.36
    203 rdf:type schema:Person
    204 sg:person.0765030013.80 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
    205 schema:familyName Fink
    206 schema:givenName James
    207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765030013.80
    208 rdf:type schema:Person
    209 sg:pub.10.1007/bf00253268 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043799871
    210 https://doi.org/10.1007/bf00253268
    211 rdf:type schema:CreativeWork
    212 sg:pub.10.1007/bf01098730 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049215951
    213 https://doi.org/10.1007/bf01098730
    214 rdf:type schema:CreativeWork
    215 sg:pub.10.1007/bf01405622 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002258513
    216 https://doi.org/10.1007/bf01405622
    217 rdf:type schema:CreativeWork
    218 sg:pub.10.1007/s00401-005-0023-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1019017045
    219 https://doi.org/10.1007/s00401-005-0023-y
    220 rdf:type schema:CreativeWork
    221 sg:pub.10.1007/s10014-008-0233-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025228341
    222 https://doi.org/10.1007/s10014-008-0233-9
    223 rdf:type schema:CreativeWork
    224 sg:pub.10.1007/s11060-006-9241-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1015983460
    225 https://doi.org/10.1007/s11060-006-9241-y
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1007/s11060-008-9520-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041842515
    228 https://doi.org/10.1007/s11060-008-9520-x
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1007/s11060-009-9801-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1041331134
    231 https://doi.org/10.1007/s11060-009-9801-z
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1007/s11864-011-0157-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047348354
    234 https://doi.org/10.1007/s11864-011-0157-1
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1038/303390a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046522629
    237 https://doi.org/10.1038/303390a0
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1038/325253a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020634435
    240 https://doi.org/10.1038/325253a0
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1038/417039a schema:sameAs https://app.dimensions.ai/details/publication/pub.1009958221
    243 https://doi.org/10.1038/417039a
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1038/nrc2403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020862106
    246 https://doi.org/10.1038/nrc2403
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1054/bjoc.2001.2100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038082325
    249 https://doi.org/10.1054/bjoc.2001.2100
    250 rdf:type schema:CreativeWork
    251 https://app.dimensions.ai/details/publication/pub.1074801127 schema:CreativeWork
    252 https://app.dimensions.ai/details/publication/pub.1076166518 schema:CreativeWork
    253 https://app.dimensions.ai/details/publication/pub.1077978740 schema:CreativeWork
    254 https://app.dimensions.ai/details/publication/pub.1079782969 schema:CreativeWork
    255 https://app.dimensions.ai/details/publication/pub.1082389319 schema:CreativeWork
    256 https://app.dimensions.ai/details/publication/pub.1083224351 schema:CreativeWork
    257 https://doi.org/10.1002/(sici)1097-0142(19971115)80:10<2005::aid-cncr19>3.0.co;2-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007563519
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1002/1097-0142(197007)26:1<138::aid-cncr2820260117>3.0.co;2-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000552119
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1002/1097-0142(197410)34:4<1069::aid-cncr2820340416>3.0.co;2-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002522789
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1002/1097-0142(197606)37:6<2580::aid-cncr2820370603>3.0.co;2-h schema:sameAs https://app.dimensions.ai/details/publication/pub.1037750522
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1002/1097-0142(197908)44:2<473::aid-cncr2820440215>3.0.co;2-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043109333
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1002/cncr.23562 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024262815
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1002/glia.440120306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036678561
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1002/glia.440140203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047828948
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1002/ijc.21865 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020123350
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1016/0090-3019(84)90397-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044712875
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1016/0163-7258(94)00047-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007376525
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1016/0165-0173(92)90007-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002119543
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1016/0167-8140(91)90125-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1017489032
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1016/0167-8140(93)90174-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053620326
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1016/0301-0082(88)90008-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050341536
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1016/0360-3016(80)90175-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040231977
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1016/0360-3016(81)90443-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052412908
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1016/0360-3016(88)90046-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038708752
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1016/0360-3016(90)90264-k schema:sameAs https://app.dimensions.ai/details/publication/pub.1047551059
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1016/0360-3016(90)90440-u schema:sameAs https://app.dimensions.ai/details/publication/pub.1046000035
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1016/0360-3016(93)90146-m schema:sameAs https://app.dimensions.ai/details/publication/pub.1015907714
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1016/j.clineuro.2010.05.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049563534
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1016/j.ijrobp.2006.10.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018013326
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1016/j.ijrobp.2009.12.061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040332699
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1016/s0009-9260(69)80043-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027321172
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1016/s0014-5793(99)00451-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019091917
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1016/s0022-510x(03)00007-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002612082
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1016/s0301-0082(98)00083-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033274977
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1016/s0360-3016(96)00239-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028651812
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1016/s1470-2045(08)70125-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004307323
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1046/j.1432-1327.2000.01597.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049888793
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1046/j.1471-4159.1999.0722334.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002910484
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1074/jbc.274.49.34884 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016634355
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1080/09553009314450861 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012996607
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1091/mbc.10.4.907 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040680649
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1093/brain/99.1.101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059444880
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1097/00005072-199906000-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021102589
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1097/00043426-200404000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000644995
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1097/01.nrl.0000080951.78533.c4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031470115
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1111/j.1750-3639.1999.tb00212.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011931168
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1139/y97-146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040388797
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1148/radiology.217.2.r00nv36377 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010183767
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1152/ajpcell.1996.271.6.c1973 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083032058
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1152/ajpcell.1999.276.4.c812 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074356972
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1152/ajpheart.2001.280.1.h434 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074739955
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1158/0008-5472.can-04-1272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052947120
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1158/1078-0432.ccr-03-0426 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015510638
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1159/000056426 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019506637
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1172/jci8218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040876780
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1200/jco.2005.06.081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064204278
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1200/jco.2008.19.1866 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045797441
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1200/jco.2008.19.4969 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001994504
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1200/jco.2009.26.3541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043187529
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1212/01.wnl.0000133398.11870.9a schema:sameAs https://app.dimensions.ai/details/publication/pub.1064346212
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1212/wnl.0b013e31821d74e7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064356197
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1212/wnl.44.11.2020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064372131
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1227/00006123-199411000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064433258
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1259/0007-1285-54-648-1081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064553752
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1259/0007-1285-61-731-1043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064557258
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1259/0007-1285-65-777-737 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064558818
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1523/jneurosci.09-12-04416.1989 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078906793
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1667/0033-7587(2000)153[0357:trotcn]2.0.co;2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068194327
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.2147/cmar.s6103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006669760
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.2307/3578068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070380636
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.2307/3579462 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070381857
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.3171/jns.1977.47.3.0336 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071091256
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.3171/jns.1979.50.5.0624 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071091793
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.3171/jns.1987.66.1.0001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071094539
    392 rdf:type schema:CreativeWork
    393 https://www.grid.ac/institutes/grid.34477.33 schema:alternateName University of Washington
    394 schema:name Department of Neurology and Neurosurgery, University of Washington/Fred Hutchinson Cancer Center, 825 Eastlake Ave E, MS: G4-940, 98109, Seattle, WA, USA
    395 Department of Pathology, University of Washington, Seattle, WA, USA
    396 rdf:type schema:Organization
    397 https://www.grid.ac/institutes/grid.4367.6 schema:alternateName Washington University in St. Louis
    398 schema:name Department of Radiology, University of Washington, St. Louis, MO, USA
    399 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...