The Swiss Transplant Cohort Study: Lessons from the First 6 Years View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-04-28

AUTHORS

Christoph Berger, Pierre-Yves Bochud, Katja Boggian, Alexia Cusini, Adrian Egli, Christian Garzoni, Hans H. Hirsch, Matthias Hoffmann, Nina Khanna, Oriol Manuel, Pascal Meylan, David Nadal, Christian van Delden, Maja Weisser, Nicolas J. Mueller, Transplant Infectious Diseases Working Group, Swiss Transplant Cohort Study

ABSTRACT

Prospective cohort studies significantly contribute to answering specific research questions in a defined population. Since 2008, the Swiss Transplant Cohort Study (STCS) systematically enrolled >95 % of all transplant recipients in Switzerland, collecting predefined data at determined time points. Designed as an open cohort, the STCS has included >3900 patients to date, with a median follow-up of 2.96 years (IQR 1.44–4.73). This review highlights some relevant findings in the field of transplant-associated infections gained by the STCS so far. Three key general aspects have crystallized: (i) Well-run cohort studies are a powerful tool to conduct genetic studies, which are crucially dependent on a meticulously described phenotype. (ii) Long-term real-life observations are adding a distinct layer of information that cannot be obtained during randomized studies. (iii) The systemic collection of data, close interdisciplinary collaboration, and continuous analysis of some key outcome data such as infectious diseases endpoints can improve patient care. More... »

PAGES

29

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11908-015-0486-5

DOI

http://dx.doi.org/10.1007/s11908-015-0486-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022755726

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25916997


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