Outbreak of Fungal Infections Associated with Contaminated Methylprednisolone Acetate: an Update View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-01

AUTHORS

April C. Pettit, Anurag N. Malani

ABSTRACT

In September 2012, an unprecedented outbreak of fungal infections due to preservative-free, injectable methylprednisolone acetate (MPA) was identified. Exserohilum rostratum was quickly identified as the predominant organism involved in disease cases. Prior to this outbreak, little was known about the pathogenesis, treatment, and prognosis of infections due to this unusual brown-black mold. Almost 2 years after the onset of this outbreak, numerous epidemiologic and basic science studies have provided some guidance in understanding the epidemiology, clinical findings, diagnosis, and treatment of patients exposed to the contaminated medication. Additionally, this outbreak has directly led to the passage of legislation supporting increased regulation in the industry of pharmaceutical compounding. Many unanswered questions, particularly surrounding the long-term prognosis and outcomes for affected patients remain. However, it is clear that a strong relationship between clinicians caring for patients and public health as well as a rapid, effective public health response was critical in preventing additional cases of disease. More... »

PAGES

441

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11908-014-0441-x

DOI

http://dx.doi.org/10.1007/s11908-014-0441-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037552406

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25416847


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Vanderbilt University", 
          "id": "https://www.grid.ac/institutes/grid.152326.1", 
          "name": [
            "Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pettit", 
        "givenName": "April C.", 
        "id": "sg:person.01161025716.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161025716.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St Joseph Mercy Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416444.7", 
          "name": [
            "Department of Medicine, Section of Infectious Diseases, St. Joseph Mercy Hospital, Ann Arbor, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Malani", 
        "givenName": "Anurag N.", 
        "id": "sg:person.0754475266.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754475266.14"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1056/nejmc1306560", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005385168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1212292", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005436512"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cid/cit808", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014818944"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jcm.00061-13", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016627585"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/infdis/jiu289", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017937277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1756-0500-7-327", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019731540", 
          "https://doi.org/10.1186/1756-0500-7-327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1756-0500-7-327", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019731540", 
          "https://doi.org/10.1186/1756-0500-7-327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1304879", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020103299"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.02357-13", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020408593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1213978", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021312709"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1212972", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027175882"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cid/cit283", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031984534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/ec.00046-13", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035039447"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cid/ciu513", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043573128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cid/ciu275", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044150470"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2013.6293", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048620005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jcm.01000-13", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051538732"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajpath.2013.05.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052109457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ofid/ofu022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053300006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-158-3-201302050-00568", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073713444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078730344", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-01", 
    "datePublishedReg": "2015-01-01", 
    "description": "In September 2012, an unprecedented outbreak of fungal infections due to preservative-free, injectable methylprednisolone acetate (MPA) was identified. Exserohilum rostratum was quickly identified as the predominant organism involved in disease cases. Prior to this outbreak, little was known about the pathogenesis, treatment, and prognosis of infections due to this unusual brown-black mold. Almost 2\u00a0years after the onset of this outbreak, numerous epidemiologic and basic science studies have provided some guidance in understanding the epidemiology, clinical findings, diagnosis, and treatment of patients exposed to the contaminated medication. Additionally, this outbreak has directly led to the passage of legislation supporting increased regulation in the industry of pharmaceutical compounding. Many unanswered questions, particularly surrounding the long-term prognosis and outcomes for affected patients remain. However, it is clear that a strong relationship between clinicians caring for patients and public health as well as a rapid, effective public health response was critical in preventing additional cases of disease. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s11908-014-0441-x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1021184", 
        "issn": [
          "1523-3847", 
          "1534-3146"
        ], 
        "name": "Current Infectious Disease Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "17"
      }
    ], 
    "name": "Outbreak of Fungal Infections Associated with Contaminated Methylprednisolone Acetate: an Update", 
    "pagination": "441", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "b2e2b438c6121e0d6a06aef399787d8dc304eb9501b58a5ad4ab67e26a2fcf26"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25416847"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100888983"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11908-014-0441-x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1037552406"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11908-014-0441-x", 
      "https://app.dimensions.ai/details/publication/pub.1037552406"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T19:11", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8678_00000523.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs11908-014-0441-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11908-014-0441-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11908-014-0441-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11908-014-0441-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11908-014-0441-x'


 

This table displays all metadata directly associated to this object as RDF triples.

139 TRIPLES      21 PREDICATES      49 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11908-014-0441-x schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author Nb09ab1acd0d248b3a3b39c2014fb2594
4 schema:citation sg:pub.10.1186/1756-0500-7-327
5 https://app.dimensions.ai/details/publication/pub.1078730344
6 https://doi.org/10.1001/jama.2013.6293
7 https://doi.org/10.1016/j.ajpath.2013.05.007
8 https://doi.org/10.1056/nejmc1306560
9 https://doi.org/10.1056/nejmoa1212292
10 https://doi.org/10.1056/nejmoa1212972
11 https://doi.org/10.1056/nejmoa1213978
12 https://doi.org/10.1056/nejmoa1304879
13 https://doi.org/10.1093/cid/cit283
14 https://doi.org/10.1093/cid/cit808
15 https://doi.org/10.1093/cid/ciu275
16 https://doi.org/10.1093/cid/ciu513
17 https://doi.org/10.1093/infdis/jiu289
18 https://doi.org/10.1093/ofid/ofu022
19 https://doi.org/10.1128/aac.02357-13
20 https://doi.org/10.1128/ec.00046-13
21 https://doi.org/10.1128/jcm.00061-13
22 https://doi.org/10.1128/jcm.01000-13
23 https://doi.org/10.7326/0003-4819-158-3-201302050-00568
24 schema:datePublished 2015-01
25 schema:datePublishedReg 2015-01-01
26 schema:description In September 2012, an unprecedented outbreak of fungal infections due to preservative-free, injectable methylprednisolone acetate (MPA) was identified. Exserohilum rostratum was quickly identified as the predominant organism involved in disease cases. Prior to this outbreak, little was known about the pathogenesis, treatment, and prognosis of infections due to this unusual brown-black mold. Almost 2 years after the onset of this outbreak, numerous epidemiologic and basic science studies have provided some guidance in understanding the epidemiology, clinical findings, diagnosis, and treatment of patients exposed to the contaminated medication. Additionally, this outbreak has directly led to the passage of legislation supporting increased regulation in the industry of pharmaceutical compounding. Many unanswered questions, particularly surrounding the long-term prognosis and outcomes for affected patients remain. However, it is clear that a strong relationship between clinicians caring for patients and public health as well as a rapid, effective public health response was critical in preventing additional cases of disease.
27 schema:genre research_article
28 schema:inLanguage en
29 schema:isAccessibleForFree false
30 schema:isPartOf N191a93c5bb27401f8c1d8b8813500bb9
31 N577d9b6e5ce84867825b761bee4346ad
32 sg:journal.1021184
33 schema:name Outbreak of Fungal Infections Associated with Contaminated Methylprednisolone Acetate: an Update
34 schema:pagination 441
35 schema:productId N0698c614ef504dada86e5bdd9bc6ea5c
36 N4d42ac0f69844ab58ad0f56d4dd70991
37 N7a5caec7e3e74323bba940c76216244c
38 Ne7978671d1984156a59bf7e17b176130
39 Nf38d7c0a5cfe481daf91cecd7bdf627b
40 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037552406
41 https://doi.org/10.1007/s11908-014-0441-x
42 schema:sdDatePublished 2019-04-10T19:11
43 schema:sdLicense https://scigraph.springernature.com/explorer/license/
44 schema:sdPublisher N03b8fce672264ad3910ceaf9749b1958
45 schema:url http://link.springer.com/10.1007%2Fs11908-014-0441-x
46 sgo:license sg:explorer/license/
47 sgo:sdDataset articles
48 rdf:type schema:ScholarlyArticle
49 N03b8fce672264ad3910ceaf9749b1958 schema:name Springer Nature - SN SciGraph project
50 rdf:type schema:Organization
51 N0698c614ef504dada86e5bdd9bc6ea5c schema:name dimensions_id
52 schema:value pub.1037552406
53 rdf:type schema:PropertyValue
54 N191a93c5bb27401f8c1d8b8813500bb9 schema:volumeNumber 17
55 rdf:type schema:PublicationVolume
56 N4d42ac0f69844ab58ad0f56d4dd70991 schema:name readcube_id
57 schema:value b2e2b438c6121e0d6a06aef399787d8dc304eb9501b58a5ad4ab67e26a2fcf26
58 rdf:type schema:PropertyValue
59 N577d9b6e5ce84867825b761bee4346ad schema:issueNumber 1
60 rdf:type schema:PublicationIssue
61 N616ee599f6f74884a6269b53bc817317 rdf:first sg:person.0754475266.14
62 rdf:rest rdf:nil
63 N7a5caec7e3e74323bba940c76216244c schema:name doi
64 schema:value 10.1007/s11908-014-0441-x
65 rdf:type schema:PropertyValue
66 Nb09ab1acd0d248b3a3b39c2014fb2594 rdf:first sg:person.01161025716.08
67 rdf:rest N616ee599f6f74884a6269b53bc817317
68 Ne7978671d1984156a59bf7e17b176130 schema:name pubmed_id
69 schema:value 25416847
70 rdf:type schema:PropertyValue
71 Nf38d7c0a5cfe481daf91cecd7bdf627b schema:name nlm_unique_id
72 schema:value 100888983
73 rdf:type schema:PropertyValue
74 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
75 schema:name Medical and Health Sciences
76 rdf:type schema:DefinedTerm
77 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
78 schema:name Clinical Sciences
79 rdf:type schema:DefinedTerm
80 sg:journal.1021184 schema:issn 1523-3847
81 1534-3146
82 schema:name Current Infectious Disease Reports
83 rdf:type schema:Periodical
84 sg:person.01161025716.08 schema:affiliation https://www.grid.ac/institutes/grid.152326.1
85 schema:familyName Pettit
86 schema:givenName April C.
87 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161025716.08
88 rdf:type schema:Person
89 sg:person.0754475266.14 schema:affiliation https://www.grid.ac/institutes/grid.416444.7
90 schema:familyName Malani
91 schema:givenName Anurag N.
92 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754475266.14
93 rdf:type schema:Person
94 sg:pub.10.1186/1756-0500-7-327 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019731540
95 https://doi.org/10.1186/1756-0500-7-327
96 rdf:type schema:CreativeWork
97 https://app.dimensions.ai/details/publication/pub.1078730344 schema:CreativeWork
98 https://doi.org/10.1001/jama.2013.6293 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048620005
99 rdf:type schema:CreativeWork
100 https://doi.org/10.1016/j.ajpath.2013.05.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052109457
101 rdf:type schema:CreativeWork
102 https://doi.org/10.1056/nejmc1306560 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005385168
103 rdf:type schema:CreativeWork
104 https://doi.org/10.1056/nejmoa1212292 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005436512
105 rdf:type schema:CreativeWork
106 https://doi.org/10.1056/nejmoa1212972 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027175882
107 rdf:type schema:CreativeWork
108 https://doi.org/10.1056/nejmoa1213978 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021312709
109 rdf:type schema:CreativeWork
110 https://doi.org/10.1056/nejmoa1304879 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020103299
111 rdf:type schema:CreativeWork
112 https://doi.org/10.1093/cid/cit283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031984534
113 rdf:type schema:CreativeWork
114 https://doi.org/10.1093/cid/cit808 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014818944
115 rdf:type schema:CreativeWork
116 https://doi.org/10.1093/cid/ciu275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044150470
117 rdf:type schema:CreativeWork
118 https://doi.org/10.1093/cid/ciu513 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043573128
119 rdf:type schema:CreativeWork
120 https://doi.org/10.1093/infdis/jiu289 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017937277
121 rdf:type schema:CreativeWork
122 https://doi.org/10.1093/ofid/ofu022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053300006
123 rdf:type schema:CreativeWork
124 https://doi.org/10.1128/aac.02357-13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020408593
125 rdf:type schema:CreativeWork
126 https://doi.org/10.1128/ec.00046-13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035039447
127 rdf:type schema:CreativeWork
128 https://doi.org/10.1128/jcm.00061-13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016627585
129 rdf:type schema:CreativeWork
130 https://doi.org/10.1128/jcm.01000-13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051538732
131 rdf:type schema:CreativeWork
132 https://doi.org/10.7326/0003-4819-158-3-201302050-00568 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073713444
133 rdf:type schema:CreativeWork
134 https://www.grid.ac/institutes/grid.152326.1 schema:alternateName Vanderbilt University
135 schema:name Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, TN, USA
136 rdf:type schema:Organization
137 https://www.grid.ac/institutes/grid.416444.7 schema:alternateName St Joseph Mercy Hospital
138 schema:name Department of Medicine, Section of Infectious Diseases, St. Joseph Mercy Hospital, Ann Arbor, MI, USA
139 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...