Is Prolonged Low-Dose Glucocorticoid Treatment Beneficial in Community-Acquired Pneumonia? View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-04

AUTHORS

Marco Confalonieri, Djillali Annane, Caterina Antonaglia, Mario Santagiuliana, Ediva M. Borriello, G. Umberto Meduri

ABSTRACT

Community-acquired pneumonia (CAP) has a significant impact on public health in terms of short-term and long-term morbidity and mortality. Irrespective of microbiological etiology, the host's inability to fully downregulate systemic inflammation is the dominant pathogenetic process contributing to acute and long-term morbidity and mortality in CAP. Glucocorticoids are the natural regulators of inflammation, and their production increases during infection. There is consistent evidence that downregulation of systemic inflammation with prolonged low-dose glucocorticoid treatment in patients with severe sepsis and acute respiratory distress syndrome improves cardiovascular and pulmonary organ physiology. A recent meta-analysis of pooled controlled small trials (n = 970) of patients admitted with CAP found improved short-term mortality in the subgroup with severe CAP and/or receiving >5 days of glucocorticoid treatment. We have expanded on this meta-analysis by including patients with CAP recruited in trials investigating prolonged low-dose glucocorticoid treatment in septic shock and/or early acute respiratory distress syndrome (n = 1,206). Our findings confirm a survival advantage for severe CAP (RR 0.66, 95% confidence interval 0.51-0.84; p = .001). A large randomized trial is in progress to confirm the aggregate findings of these small trials and to evaluate the long-term effect of this low-cost treatment. More... »

PAGES

158-166

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11908-013-0322-8

DOI

http://dx.doi.org/10.1007/s11908-013-0322-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013419875

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23371407


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