Immune restoration inflammatory syndromes: The dark side of successful antiretroviral treatment View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-05

AUTHORS

Matthias Stoll, Reinhold E. Schmidt

ABSTRACT

The prevalence of cellular immunodeficiency has increased due to rising use of immunosuppressive therapies and the pandemic spread of HIV infection. More recently, the introduction of highly active antiretroviral therapy (HAART) in HIV has led to significant immune reconstitution, even in patients with previously long-lasting secondary immunodeficiency. HAART reduces morbidity and mortality in HIV infection and also changes the clinical course of prevalent subclinical opportunistic infections or autoimmune diseases. Atypical inflammatory disorders develop after initiation of HAART and have been summarized as "immune reconstitution syndrome," "immune restoration disease," and "immune restoration inflammatory syndrome." However, diagnostic criteria and standards of therapy are yet to be defined. The awareness for these diseases is of increasing importance from a clinical point of view. This review summarizes the variety of immunoreconstitution disorders and describes possible diagnostic pitfalls. We also propose possible therapeutic options. More... »

PAGES

266-276

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11908-003-0083-x

DOI

http://dx.doi.org/10.1007/s11908-003-0083-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003570092

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12760825


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