Renal Generation of Angiotensin II and the Pathogenesis of Hypertension View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-08-06

AUTHORS

Jorge F. Giani, Tea Janjulia, Brian Taylor, Ellen A. Bernstein, Kandarp Shah, Xiao Z. Shen, Alicia A. McDonough, Kenneth E. Bernstein, Romer A. Gonzalez-Villalobos

ABSTRACT

The existence of a complete and functional renin-angiotensin system along the nephron is widely recognized. However, its precise role in blood pressure control and, by extension, hypertension is still uncertain. While most investigators agree that overexpressing RAS components along the nephron results in hypertension, two important issues remain: whether the local RAS works as a separate entity or represents an extension of the systemic RAS and whether locally generated angiotensin II has specific renal effects on blood pressure that are distinct from systemic angiotensin II. This review addresses these issues while emphasizing the unique role of local angiotensin II in the response of the kidney to hypertensive stimuli and the induction of hypertension. More... »

PAGES

477

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11906-014-0477-1

DOI

http://dx.doi.org/10.1007/s11906-014-0477-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023664101

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25097114


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