Impact of the AT2 Receptor Agonist C21 on Blood Pressure and Beyond View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-10

AUTHORS

Sébastien Foulquier, U. Muscha Steckelings, Thomas Unger

ABSTRACT

It is now widely accepted that the angiotensin AT(2) receptor (AT(2)R) plays an important protective role during pathophysiologic conditions, acting as a repair system. The development of the first selective nonpeptide AT(2)R agonist C21 accelerated our understanding of AT(2)R-mediated protective signaling and actions. This article reviews the impact of C21 on blood pressure in normotensive and hypertensive animal models. Although C21 does not act as a classical antihypertensive drug, it could be useful in preventing hypertension-induced vascular and other end organ damages via anti-apoptotic, anti-fibrotic and anti-inflammatory actions. In particular, a strong body of evidence started to emerge around its anti-inflammatory feature. This property should be further investigated for potential clinical indications in cardiovascular diseases and beyond. More... »

PAGES

403-409

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11906-012-0291-6

DOI

http://dx.doi.org/10.1007/s11906-012-0291-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013882267

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22836386


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RDF/XML is a standard XML format for linked data.

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