Newly recognized physiologic and pathophysiologic actions of the angiotensin-converting enzyme View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-04

AUTHORS

Sebastien Fuchs, Kristen Frenzel, Hong D. Xiao, Jonathan W. Adams, Hui Zhao, George Keshelava, Lu Teng, Kenneth E. Bernstein

ABSTRACT

Despite several decades of research into the renin-angiotensin system, new aspects of this endocrine system are elucidated every few years, expanding its role not only in hypertension but also in diabetes, oncology, and cardiology. In this review, we describe newly recognized physiologic actions of the angiotensin-converting enzyme (ACE). These include the role of local versus systemic ACE in maintaining blood pressure, the physiology of bradykinin accumulation during ACE inactivation, and the role of alternate “nonangiotensin” substrates and potential non-enzymatic properties of ACE. More... »

PAGES

124-128

References to SciGraph publications

  • 2003-03-28. A story of two ACEs in JOURNAL OF MOLECULAR MEDICINE
  • 1995-05. Male–female differences in fertility and blood pressure in ACE-deficient mice in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11906-004-0087-4

    DOI

    http://dx.doi.org/10.1007/s11906-004-0087-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1007253118

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/15010016


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