Ontology type: schema:ScholarlyArticle Open Access: True
2016-02-03
AUTHORSKathryn E. Stephenson, Dan H. Barouch
ABSTRACTPassive transfer of antibodies has long been considered a potential treatment modality for infectious diseases, including HIV. Early efforts to use antibodies to suppress HIV replication, however, were largely unsuccessful, as the antibodies that were studied neutralized only a relatively narrow spectrum of viral strains and were not very potent. Recent advances have led to the discovery of a large portfolio of human monoclonal antibodies that are broadly neutralizing across many HIV-1 subtypes and are also substantially more potent. These antibodies target multiple different epitopes on the HIV envelope, thus allowing for the development of antibody combinations. In this review, we discuss the application of broadly neutralizing antibodies (bNAbs) for HIV treatment and HIV eradication strategies. We highlight bNAbs that target key epitopes, such as the CD4 binding site and the V2/V3-glycan-dependent sites, and we discuss several bNAbs that are currently in the clinical development pipeline. More... »
PAGES31-37
http://scigraph.springernature.com/pub.10.1007/s11904-016-0299-7
DOIhttp://dx.doi.org/10.1007/s11904-016-0299-7
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1005667407
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/26841901
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Immunology",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antibodies, Monoclonal",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antibodies, Neutralizing",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antibodies, Viral",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Binding Sites",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Epitopes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "HIV Envelope Protein gp120",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "HIV Infections",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "HIV-1",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Immunotherapy, Adoptive",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Peptide Fragments",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Viral Envelope Proteins",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Ragon Institute of MGH, MIT, and Harvard, Boston, MA USA",
"id": "http://www.grid.ac/institutes/grid.461656.6",
"name": [
"Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, E/CLS-1043, 330 Brookline Avenue, Boston, MA 02215 USA",
"Ragon Institute of MGH, MIT, and Harvard, Boston, MA USA"
],
"type": "Organization"
},
"familyName": "Stephenson",
"givenName": "Kathryn E.",
"id": "sg:person.01251576771.89",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251576771.89"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ragon Institute of MGH, MIT, and Harvard, Boston, MA USA",
"id": "http://www.grid.ac/institutes/grid.461656.6",
"name": [
"Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, E/CLS-1043, 330 Brookline Avenue, Boston, MA 02215 USA",
"Ragon Institute of MGH, MIT, and Harvard, Boston, MA USA"
],
"type": "Organization"
},
"familyName": "Barouch",
"givenName": "Dan H.",
"id": "sg:person.0644324362.10",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644324362.10"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/nature13036",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032264965",
"https://doi.org/10.1038/nature13036"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature12744",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025637640",
"https://doi.org/10.1038/nature12744"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature10696",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016437859",
"https://doi.org/10.1038/nature10696"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature12746",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029594927",
"https://doi.org/10.1038/nature12746"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature10373",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044845665",
"https://doi.org/10.1038/nature10373"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nm1244",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003729367",
"https://doi.org/10.1038/nm1244"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature14411",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045337010",
"https://doi.org/10.1038/nature14411"
],
"type": "CreativeWork"
}
],
"datePublished": "2016-02-03",
"datePublishedReg": "2016-02-03",
"description": "Passive transfer of antibodies has long been considered a potential treatment modality for infectious diseases, including HIV. Early efforts to use antibodies to suppress HIV replication, however, were largely unsuccessful, as the antibodies that were studied neutralized only a relatively narrow spectrum of viral strains and were not very potent. Recent advances have led to the discovery of a large portfolio of human monoclonal antibodies that are broadly neutralizing across many HIV-1 subtypes and are also substantially more potent. These antibodies target multiple different epitopes on the HIV envelope, thus allowing for the development of antibody combinations. In this review, we discuss the application of broadly neutralizing antibodies (bNAbs) for HIV treatment and HIV eradication strategies. We highlight bNAbs that target key epitopes, such as the CD4 binding site and the V2/V3-glycan-dependent sites, and we discuss several bNAbs that are currently in the clinical development pipeline. ",
"genre": "article",
"id": "sg:pub.10.1007/s11904-016-0299-7",
"inLanguage": "en",
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1034743",
"issn": [
"1548-3568",
"1548-3576"
],
"name": "Current HIV/AIDS Reports",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "13"
}
],
"keywords": [
"HIV eradication strategies",
"HIV-1 subtypes",
"potential treatment modality",
"human monoclonal antibody",
"clinical development pipeline",
"HIV eradication",
"HIV replication",
"HIV treatment",
"treatment modalities",
"neutralizing antibodies",
"HIV envelope",
"passive transfer",
"antibody combinations",
"infectious diseases",
"viral strains",
"different epitopes",
"monoclonal antibodies",
"key epitopes",
"antibodies",
"eradication strategies",
"development pipeline",
"epitopes",
"CD4",
"HIV",
"bnAbs",
"subtypes",
"disease",
"narrow spectrum",
"eradication",
"modalities",
"treatment",
"recent advances",
"review",
"replication",
"sites",
"strains",
"advances",
"combination",
"development",
"strategies",
"discovery",
"efforts",
"early efforts",
"envelope",
"transfer",
"spectra",
"applications",
"pipeline",
"large portfolio",
"portfolio",
"multiple different epitopes",
"V2/V3-glycan-dependent sites",
"V3-glycan-dependent sites"
],
"name": "Broadly Neutralizing Antibodies for HIV Eradication",
"pagination": "31-37",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1005667407"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s11904-016-0299-7"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"26841901"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s11904-016-0299-7",
"https://app.dimensions.ai/details/publication/pub.1005667407"
],
"sdDataset": "articles",
"sdDatePublished": "2022-01-01T18:41",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_709.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/s11904-016-0299-7"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11904-016-0299-7'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11904-016-0299-7'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11904-016-0299-7'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11904-016-0299-7'
This table displays all metadata directly associated to this object as RDF triples.
203 TRIPLES
22 PREDICATES
99 URIs
83 LITERALS
19 BLANK NODES