Optimal Management of Portal Vein Thrombosis in Patients with Liver Cirrhosis: a Review View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-09

AUTHORS

Geneviève Huard, Julien Bissonnette, Marc Bilodeau

ABSTRACT

Portal vein thrombosis (PVT) is a fairly common complication of cirrhosis, especially in patients with advanced liver disease and reduced portal vein flow velocity. Prospective studies have shown that its occurrence parallels rather than causes the progression of liver disease and that spontaneous regression is a frequent finding. PVT occurrence is associated with an increased mortality after liver transplantation. Treatment options include anticoagulation and insertion of a transjugular intrahepatic portosystemic shunt. Anticoagulation with vitamin K antagonists or low-molecular-weight heparins achieves partial or complete portal vein recanalization in most patients. Anticoagulation does not seem to increase the bleeding risk when proper prophylaxis of variceal bleeding is applied. Monitoring of anticoagulation difficulties exist, inherent to the coagulopathy of chronic liver disease. Placement of a transjugular intrahepatic portosystemic shunt is an alternative in selected patients. Trials are underway to evaluate the potential benefit of PVT prophylaxis with low-molecular-weight heparins. More... »

PAGES

203-211

Journal

TITLE

Current Hepatology Reports

ISSUE

3

VOLUME

14

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11901-015-0273-7

DOI

http://dx.doi.org/10.1007/s11901-015-0273-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044063665


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Turtle is a human-readable linked data format.

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RDF/XML is a standard XML format for linked data.

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