Checkpoint Inhibitors Hodgkin Lymphoma and Non-Hodgkin Lymphoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-12

AUTHORS

Bei Hu, Ryan Jacobs, Nilanjan Ghosh

ABSTRACT

PURPOSE OF THE REVIEW: The ligation of PD-1 with PD-L1 activates a critical immune checkpoint leading to T cell dysfunction, exhaustion, and tolerance. Anti-PD-1 or anti-PD-L1 monoclonal antibodies can reverse the immune checkpoint, releasing the brake on T cell responses. We provide a comprehensive review of the literature on the activity of checkpoint inhibitors in lymphoma. RECENT FINDINGS: We discuss the latest findings with checkpoint inhibitors in lymphoma and new promising studies incorporating these agents. Classical Hodgkin lymphoma is very sensitive to PD1/PL1 blockade due to genetic alterations in 9p21.1 leading to the high expression of PDL1. Although majority of NHLs have a much lower sensitivity to PD1/PDL1 blockade, a few subtypes such as primary CNS lymphoma, primary testicular lymphoma, primary mediastinal lymphoma harbor 9p21.1 alterations making them vulnerable to PD1 blockade. EBV-associated lymphomas have a virally mediated increased expression of PDL1 making them sensitive to PD1 blockade. More... »

PAGES

1-12

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11899-018-0484-4

DOI

http://dx.doi.org/10.1007/s11899-018-0484-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1107701713

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30338457


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