The Future of B-Cell Lymphoma Therapy: The B-Cell Receptor and its Downstream Pathways View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-09

AUTHORS

Vaishalee P. Kenkre, Brad S. Kahl

ABSTRACT

It is becoming increasingly apparent that tonic signaling through the B cell receptor provides a growth and survival signal in many types of B cell lymphomas, and that disruption of B cell receptor signaling can be lethal to malignant B cells. Several small molecule tyrosine kinase inhibitors, which block signaling pathways downstream from the B cell receptor, are in active clinical development. Preliminary data suggests impressive activity in relapsed and refractory B cell lymphomas. Among the kinases which have been targeted are Spleen tyrosine kinase (Syk), the Bruton's tyrosine kinase (BTK), and phosphoinositide 3-kinase (PI3K). This article discusses the rationale for targeting these pathways and summarizes the current clinical trial data for agents targeting Syk, BTK, and PI3K. More... »

PAGES

216-220

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11899-012-0127-0

DOI

http://dx.doi.org/10.1007/s11899-012-0127-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013176123

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22688757


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