Platelet Activating Factor in Heart Failure: Potential Role in Disease Progression and Novel Target for Therapy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-06

AUTHORS

Paraskevi Detopoulou, Tzortzis Nomikos, Elizabeth Fragopoulou, Christina Chrysohoou, Smaragdi Antonopoulou

ABSTRACT

Heart failure (HF) is a complex syndrome with cardiac, renal, neurohormonal and sympathetic nervous system's manifestations, the pathogenesis of which among others is connected to inflammation. PAF has local and systemic effects pertaining to HF progression since it causes a negative inotropic effect, it induces arrhythmias, it induces apoptosis and it is involved in inflammation and atherosclerosis. In the present review the role of PAF in HF will be thoroughly presented along with the relevant data on PAF enzymes and the potential role of PAF metabolic circuit as a novel pharmacological target. More... »

PAGES

122-129

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11897-013-0131-2

DOI

http://dx.doi.org/10.1007/s11897-013-0131-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039184333

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23389700


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