CD-NP: An Innovative Designer Natriuretic Peptide Activator of Particulate Guanylyl Cyclase Receptors for Cardiorenal Disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-06-29

AUTHORS

Paul M. McKie, S. Jeson Sangaralingham, John C. Burnett

ABSTRACT

The natriuretic peptide (NP) family consists of structurally similar, although physiologically distinct, peptides that play an important role in cardiorenal homeostasis. CD-NP is a novel chimeric natriuretic peptide developed by the Mayo Clinic, in which the 15-amino acid COOH-terminus of dendroaspis NP is fused to C-type NP. CD-NP is a dual activator of NP receptors A and B, and therefore, possesses the strong antiproliferative and antifibrotic properties of C-type NP with the potent natriuretic, diuretic, and aldosterone-inhibiting properties of dendroaspis NP. CD-NP has favorable cardiorenal properties when compared to recombinant B-type NP (nesiritide), including preservation of glomerular filtration rate with minimal blood pressure-lowering effects. Thus, CD-NP has emerged as an appealing novel therapeutic strategy for heart failure. The endogenous NP system, the development rationale for CD-NP, as well as in vitro, animal, and human studies and future directions will be reviewed. More... »

PAGES

93-99

References to SciGraph publications

  • 2008-06. Insights into natriuretic peptides in heart failure: An update in CURRENT HEART FAILURE REPORTS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11897-010-0016-6

    DOI

    http://dx.doi.org/10.1007/s11897-010-0016-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1022530445

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20582736


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