Insights in immunomodulatory therapies for ulcerative colitis and Crohn’s disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-11

AUTHORS

Geoffrey C. Nguyen, Mary L. Harris, Themistocles Dassopoulos

ABSTRACT

Immunomodulators are a class of drugs that attenuate the underlying inflammatory processes of Crohn's disease (CD) and ulcerative colitis (UC), the two major inflammatory bowel diseases (IBD). These agents play a prominent role in the management of refractory and steroid-dependent IBD. The immunomodulatory drugs in the IBD arsenal include azathioprine, 6-mercaptopurine, methotrexate, cyclosporine, and tacrolimus. Azathioprine and 6-mercaptopurine are considered first-line immunosuppressants due to their proven efficacy in both CD and UC and their safety profile, whereas cyclosporine occupies a niche as a surgery-sparing agent in the acute management of severe, steroid-refractory UC. Immunomodulators also appear to have a role as adjunctive therapy when used with infliximab or other biologic agents to reduce immunogenicity. Although data have been limited to observational studies, azathioprine and 6-mercaptopurine may be used during pregnancy. More... »

PAGES

499-505

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11894-006-0040-6

DOI

http://dx.doi.org/10.1007/s11894-006-0040-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026049971

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17105689


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