Interleukin 2 in the Pathogenesis and Therapy of Type 1 Diabetes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-12

AUTHORS

Michelle Rosenzwajg, Guillaume Churlaud, Agnès Hartemann, David Klatzmann

ABSTRACT

Regulatory T cells (Tregs) play a major role in controlling effector T cells (Teffs) responding to self-antigens, which cause autoimmune diseases. An improper Treg/Teff balance contributes to most autoimmune diseases, including type 1 diabetes (T1D). To restore a proper balance, blocking Teffs with immunosuppressants has been the only option, which was partly effective and too toxic. It now appears that expanding/activating Tregs with low-dose interleukin-2 (IL-2) could provide immunoregulation without immunosuppression. This is particularly interesting in T1D as Tregs from T1D patients are reported as dysfunctional and a relative deficiency in IL-2 production and/or IL-2-mediated signaling could contribute to this phenotype. A clinical study of low-dose IL-2 showed a very good safety profile and good Treg expansion/activation in T1D patients. This opens the way for efficacy trials to test low-dose IL-2 in prevention and treatment of T1D and to establish in which condition restoration of a proper Treg/Teff balance would be beneficial in the field of autoimmune and inflammatory diseases. More... »

PAGES

553

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11892-014-0553-6

    DOI

    http://dx.doi.org/10.1007/s11892-014-0553-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1010510863

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25344788


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