Antioxidants and Diabetic Retinopathy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-05-07

AUTHORS

Michael Williams, Ruth E. Hogg, Usha Chakravarthy

ABSTRACT

The biochemical perturbations in diabetes mellitus (DM) create the conditions for the production of free radicals, the consequence of which is increased oxidative stress. Evidence has accrued over the past 2 decades that suggests that oxidative stress is an important pathogenetic factor in the development of diabetic retinopathy (DR). Experimental data show that the use of strategies that ameliorate oxidative stress can prevent and retard the development of DR in the animal model. Clinical observations also suggest that reducing oxidative stress may help to reverse pathological manifestations of DR. The present article constitutes an examination of the role of antioxidants in the management of DR and the current state of clinically relevant knowledge. More... »

PAGES

481-487

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11892-013-0384-x

DOI

http://dx.doi.org/10.1007/s11892-013-0384-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021626205

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23649947


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1113", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Ophthalmology and Optometry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antioxidants", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diabetic Retinopathy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diet", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hyperglycemia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oxidative Stress", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retina", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Medical Ophthalmology, Department of Ophthalmology, Royal Victoria Hospital, Belfast Health and Social Care Trust, BT12 6BA, Belfast, Northern Ireland, UK", 
          "id": "http://www.grid.ac/institutes/grid.416232.0", 
          "name": [
            "Medical Ophthalmology, Department of Ophthalmology, Royal Victoria Hospital, Belfast Health and Social Care Trust, BT12 6BA, Belfast, Northern Ireland, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Williams", 
        "givenName": "Michael", 
        "id": "sg:person.01021727410.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021727410.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre for Vision and Vascular Science, Queen\u2019s University of Belfast, Institute of Clinical Science Block A, Royal Victoria Hospital, BT12 6BA, Belfast, Northern Ireland, UK", 
          "id": "http://www.grid.ac/institutes/grid.416232.0", 
          "name": [
            "Centre for Vision and Vascular Science, Queen\u2019s University of Belfast, Institute of Clinical Science Block A, Royal Victoria Hospital, BT12 6BA, Belfast, Northern Ireland, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hogg", 
        "givenName": "Ruth E.", 
        "id": "sg:person.01206102735.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206102735.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre for Vision and Vascular Science, Queen\u2019s University of Belfast, Institute of Clinical Science Block A, Royal Victoria Hospital, BT12 6BA, Belfast, Northern Ireland, UK", 
          "id": "http://www.grid.ac/institutes/grid.416232.0", 
          "name": [
            "Centre for Vision and Vascular Science, Queen\u2019s University of Belfast, Institute of Clinical Science Block A, Royal Victoria Hospital, BT12 6BA, Belfast, Northern Ireland, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chakravarthy", 
        "givenName": "Usha", 
        "id": "sg:person.01330651607.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330651607.77"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s001250100631", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023196747", 
          "https://doi.org/10.1007/s001250100631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/11596840-000000000-00000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007041832", 
          "https://doi.org/10.2165/11596840-000000000-00000"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-05-07", 
    "datePublishedReg": "2013-05-07", 
    "description": "The biochemical perturbations in diabetes mellitus (DM) create the conditions for the production of free radicals, the consequence of which is increased oxidative stress. Evidence has accrued over the past 2 decades that suggests that oxidative stress is an important pathogenetic factor in the development of diabetic retinopathy (DR). Experimental data show that the use of strategies that ameliorate oxidative stress can prevent and retard the development of DR in the animal model. Clinical observations also suggest that reducing oxidative stress may help to reverse pathological manifestations of DR. The present article constitutes an examination of the role of antioxidants in the management of DR and the current state of clinically relevant knowledge.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s11892-013-0384-x", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1028990", 
        "issn": [
          "1534-4827", 
          "1539-0829"
        ], 
        "name": "Current Diabetes Reports", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "13"
      }
    ], 
    "keywords": [
      "diabetic retinopathy", 
      "oxidative stress", 
      "diabetes mellitus", 
      "management of DR", 
      "development of DR", 
      "important pathogenetic factor", 
      "role of antioxidants", 
      "pathogenetic factor", 
      "animal models", 
      "clinical observations", 
      "pathological manifestations", 
      "biochemical perturbations", 
      "retinopathy", 
      "free radicals", 
      "antioxidants", 
      "mellitus", 
      "use of strategies", 
      "manifestations", 
      "examination", 
      "stress", 
      "evidence", 
      "management", 
      "factors", 
      "development", 
      "role", 
      "use", 
      "present article", 
      "current state", 
      "data", 
      "consequences", 
      "strategies", 
      "knowledge", 
      "relevant knowledge", 
      "decades", 
      "production", 
      "radicals", 
      "observations", 
      "conditions", 
      "article", 
      "model", 
      "state", 
      "perturbations", 
      "experimental data"
    ], 
    "name": "Antioxidants and Diabetic Retinopathy", 
    "pagination": "481-487", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1021626205"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11892-013-0384-x"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23649947"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11892-013-0384-x", 
      "https://app.dimensions.ai/details/publication/pub.1021626205"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:29", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_586.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s11892-013-0384-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11892-013-0384-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11892-013-0384-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11892-013-0384-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11892-013-0384-x'


 

This table displays all metadata directly associated to this object as RDF triples.

161 TRIPLES      22 PREDICATES      78 URIs      68 LITERALS      15 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11892-013-0384-x schema:about N13036e7af6e948b083b6ffbea2d1debc
2 N5a6e6cd1d2de444eb0bc8f090ab03732
3 N6bfa55f6c9ba41019844e64c978ce4d5
4 N87f20318433f4f73bc55688dda6c84b9
5 Nc060878870f443b0b4c7b64561c28011
6 Ncca794798a15423581f01b3faf4f91d5
7 Ne01717731311460cab5f446ec816da43
8 Ne4a3e1d1a4bf458a987230afae964d90
9 anzsrc-for:11
10 anzsrc-for:1113
11 schema:author N8a11d89c92ea464f96bd27588fa92ef5
12 schema:citation sg:pub.10.1007/s001250100631
13 sg:pub.10.2165/11596840-000000000-00000
14 schema:datePublished 2013-05-07
15 schema:datePublishedReg 2013-05-07
16 schema:description The biochemical perturbations in diabetes mellitus (DM) create the conditions for the production of free radicals, the consequence of which is increased oxidative stress. Evidence has accrued over the past 2 decades that suggests that oxidative stress is an important pathogenetic factor in the development of diabetic retinopathy (DR). Experimental data show that the use of strategies that ameliorate oxidative stress can prevent and retard the development of DR in the animal model. Clinical observations also suggest that reducing oxidative stress may help to reverse pathological manifestations of DR. The present article constitutes an examination of the role of antioxidants in the management of DR and the current state of clinically relevant knowledge.
17 schema:genre article
18 schema:inLanguage en
19 schema:isAccessibleForFree false
20 schema:isPartOf Na6d65a2a5413493e949d3c2ff4afc4ec
21 Nd31590ad4b6b431da7aa8caf693d08fb
22 sg:journal.1028990
23 schema:keywords animal models
24 antioxidants
25 article
26 biochemical perturbations
27 clinical observations
28 conditions
29 consequences
30 current state
31 data
32 decades
33 development
34 development of DR
35 diabetes mellitus
36 diabetic retinopathy
37 evidence
38 examination
39 experimental data
40 factors
41 free radicals
42 important pathogenetic factor
43 knowledge
44 management
45 management of DR
46 manifestations
47 mellitus
48 model
49 observations
50 oxidative stress
51 pathogenetic factor
52 pathological manifestations
53 perturbations
54 present article
55 production
56 radicals
57 relevant knowledge
58 retinopathy
59 role
60 role of antioxidants
61 state
62 strategies
63 stress
64 use
65 use of strategies
66 schema:name Antioxidants and Diabetic Retinopathy
67 schema:pagination 481-487
68 schema:productId N0ed81fd0a42c4391afa6c7a1ffcf40de
69 N7416a276f44947b7a2bfc7eee3ef1001
70 Ndfdf54e714284b579e3e6a1b2893508a
71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021626205
72 https://doi.org/10.1007/s11892-013-0384-x
73 schema:sdDatePublished 2022-01-01T18:29
74 schema:sdLicense https://scigraph.springernature.com/explorer/license/
75 schema:sdPublisher Nd98764505e17406aa8a84bba7efcbd77
76 schema:url https://doi.org/10.1007/s11892-013-0384-x
77 sgo:license sg:explorer/license/
78 sgo:sdDataset articles
79 rdf:type schema:ScholarlyArticle
80 N0ed81fd0a42c4391afa6c7a1ffcf40de schema:name pubmed_id
81 schema:value 23649947
82 rdf:type schema:PropertyValue
83 N13036e7af6e948b083b6ffbea2d1debc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Humans
85 rdf:type schema:DefinedTerm
86 N1e80be8befa54a6ca1193a1ddf6a075f rdf:first sg:person.01206102735.69
87 rdf:rest N9a5aa375038c45c0bca74b5b0dfb3fa8
88 N5a6e6cd1d2de444eb0bc8f090ab03732 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Animals
90 rdf:type schema:DefinedTerm
91 N6bfa55f6c9ba41019844e64c978ce4d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Diet
93 rdf:type schema:DefinedTerm
94 N7416a276f44947b7a2bfc7eee3ef1001 schema:name doi
95 schema:value 10.1007/s11892-013-0384-x
96 rdf:type schema:PropertyValue
97 N87f20318433f4f73bc55688dda6c84b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Diabetic Retinopathy
99 rdf:type schema:DefinedTerm
100 N8a11d89c92ea464f96bd27588fa92ef5 rdf:first sg:person.01021727410.31
101 rdf:rest N1e80be8befa54a6ca1193a1ddf6a075f
102 N9a5aa375038c45c0bca74b5b0dfb3fa8 rdf:first sg:person.01330651607.77
103 rdf:rest rdf:nil
104 Na6d65a2a5413493e949d3c2ff4afc4ec schema:volumeNumber 13
105 rdf:type schema:PublicationVolume
106 Nc060878870f443b0b4c7b64561c28011 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Oxidative Stress
108 rdf:type schema:DefinedTerm
109 Ncca794798a15423581f01b3faf4f91d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Retina
111 rdf:type schema:DefinedTerm
112 Nd31590ad4b6b431da7aa8caf693d08fb schema:issueNumber 4
113 rdf:type schema:PublicationIssue
114 Nd98764505e17406aa8a84bba7efcbd77 schema:name Springer Nature - SN SciGraph project
115 rdf:type schema:Organization
116 Ndfdf54e714284b579e3e6a1b2893508a schema:name dimensions_id
117 schema:value pub.1021626205
118 rdf:type schema:PropertyValue
119 Ne01717731311460cab5f446ec816da43 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Hyperglycemia
121 rdf:type schema:DefinedTerm
122 Ne4a3e1d1a4bf458a987230afae964d90 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Antioxidants
124 rdf:type schema:DefinedTerm
125 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
126 schema:name Medical and Health Sciences
127 rdf:type schema:DefinedTerm
128 anzsrc-for:1113 schema:inDefinedTermSet anzsrc-for:
129 schema:name Ophthalmology and Optometry
130 rdf:type schema:DefinedTerm
131 sg:journal.1028990 schema:issn 1534-4827
132 1539-0829
133 schema:name Current Diabetes Reports
134 schema:publisher Springer Nature
135 rdf:type schema:Periodical
136 sg:person.01021727410.31 schema:affiliation grid-institutes:grid.416232.0
137 schema:familyName Williams
138 schema:givenName Michael
139 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021727410.31
140 rdf:type schema:Person
141 sg:person.01206102735.69 schema:affiliation grid-institutes:grid.416232.0
142 schema:familyName Hogg
143 schema:givenName Ruth E.
144 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206102735.69
145 rdf:type schema:Person
146 sg:person.01330651607.77 schema:affiliation grid-institutes:grid.416232.0
147 schema:familyName Chakravarthy
148 schema:givenName Usha
149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330651607.77
150 rdf:type schema:Person
151 sg:pub.10.1007/s001250100631 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023196747
152 https://doi.org/10.1007/s001250100631
153 rdf:type schema:CreativeWork
154 sg:pub.10.2165/11596840-000000000-00000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007041832
155 https://doi.org/10.2165/11596840-000000000-00000
156 rdf:type schema:CreativeWork
157 grid-institutes:grid.416232.0 schema:alternateName Centre for Vision and Vascular Science, Queen’s University of Belfast, Institute of Clinical Science Block A, Royal Victoria Hospital, BT12 6BA, Belfast, Northern Ireland, UK
158 Medical Ophthalmology, Department of Ophthalmology, Royal Victoria Hospital, Belfast Health and Social Care Trust, BT12 6BA, Belfast, Northern Ireland, UK
159 schema:name Centre for Vision and Vascular Science, Queen’s University of Belfast, Institute of Clinical Science Block A, Royal Victoria Hospital, BT12 6BA, Belfast, Northern Ireland, UK
160 Medical Ophthalmology, Department of Ophthalmology, Royal Victoria Hospital, Belfast Health and Social Care Trust, BT12 6BA, Belfast, Northern Ireland, UK
161 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...