Experimental Approaches for High-Resolution In Vivo Imaging of Islet of Langerhans Biology View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-10

AUTHORS

Stephan Speier

ABSTRACT

Under physiological conditions and in the pathogenesis of diabetes mellitus systemic influences play a substantial role for function and survival of cells of the islet of Langerhans. Therefore, in vivo studies to understand islet biology are indispensible and imaging techniques are increasingly used for this purpose. Among the diverse imaging modalities currently only laser scanning microscopy (LSM) allows resolution and visualization of individual cells and cellular processes. To overcome limited tissue penetration and working distance of LSM and enable in vivo investigations of islet cell physiology, various experimental approaches have been developed. Especially, the recently developed imaging platforms have significantly improved the possibility to study islets at a cellular level in vivo, and provided novel insight into islet biology in health and disease. The various approaches, their applications, and reported results, as well as their limitations are reviewed in this article. More... »

PAGES

420

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11892-011-0207-x

DOI

http://dx.doi.org/10.1007/s11892-011-0207-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022335452

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21701794


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diagnostic Imaging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin-Secreting Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Islets of Langerhans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Islets of Langerhans Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microscopy, Confocal", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "TU Dresden", 
          "id": "https://www.grid.ac/institutes/grid.4488.0", 
          "name": [
            "Center for Regenerative Therapies Dresden and Paul Langerhans Institute Dresden, School of Medicine, Dresden University of Technology, 01307, Dresden, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Speier", 
        "givenName": "Stephan", 
        "id": "sg:person.01336451370.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336451370.12"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.gde.2009.07.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000657101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0026-2862(91)90022-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000836606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000055792", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001431920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2818.1994.tb03524.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004179064"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0083-6729(08)00609-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005426901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci117228", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011501302"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001250051322", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013383274", 
          "https://doi.org/10.1007/s001250051322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001250051322", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013383274", 
          "https://doi.org/10.1007/s001250051322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/aja.1001260402", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017693074"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0185(199808)251:4<448::aid-ar4>3.0.co;2-o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018504347"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.2155", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018736702", 
          "https://doi.org/10.1038/nm.2155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.2155", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018736702", 
          "https://doi.org/10.1038/nm.2155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ar.1091460205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021179323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006676-199604000-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022560501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006676-199604000-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022560501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci36209", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022630398"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpendo.00321.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022745317"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpendo.00715.2009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024942910"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ar.1090400204", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030457540"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/db06-0232", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030586992"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.10-158121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030680749"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpendo.90544.2008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030987262"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1679/aohc.46.315", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032764509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1701", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034500059", 
          "https://doi.org/10.1038/nm1701"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2567.1999.00826.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035421829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-065x.2008.00581.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039863422"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0015732", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040189065"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bc100184w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040487463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bc100184w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040487463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006676-199301000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040594480"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006676-199301000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040594480"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2008.118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041033403", 
          "https://doi.org/10.1038/nprot.2008.118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mce.2004.11.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041274102"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1098/rsif.2005.0040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041649281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00424-003-1097-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042328651", 
          "https://doi.org/10.1007/s00424-003-1097-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrendo.2009.103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045189479", 
          "https://doi.org/10.1038/nrendo.2009.103"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrendo.2009.103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045189479", 
          "https://doi.org/10.1038/nrendo.2009.103"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11307-009-0240-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046505667", 
          "https://doi.org/10.1007/s11307-009-0240-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11307-009-0240-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046505667", 
          "https://doi.org/10.1007/s11307-009-0240-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/db10-0205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049342098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-4886(87)90122-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049468447"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-009-1383-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050051160", 
          "https://doi.org/10.1007/s00125-009-1383-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-009-1383-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050051160", 
          "https://doi.org/10.1007/s00125-009-1383-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-009-1383-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050051160", 
          "https://doi.org/10.1007/s00125-009-1383-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-009-1383-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050051160", 
          "https://doi.org/10.1007/s00125-009-1383-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/acta.0.0290473", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052009821"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199706150-00020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060276673"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199706150-00020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060276673"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199706150-00020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060276673"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2321027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062532641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2009-1313", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064250332"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1364/ol.31.002450", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1065224146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/092986706778521940", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069160799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diab.38.1.s199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070735666"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2144/03354st01", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076587033"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077746436", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078303131", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078661152", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083004868", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-10", 
    "datePublishedReg": "2011-10-01", 
    "description": "Under physiological conditions and in the pathogenesis of diabetes mellitus systemic influences play a substantial role for function and survival of cells of the islet of Langerhans. Therefore, in vivo studies to understand islet biology are indispensible and imaging techniques are increasingly used for this purpose. Among the diverse imaging modalities currently only laser scanning microscopy (LSM) allows resolution and visualization of individual cells and cellular processes. To overcome limited tissue penetration and working distance of LSM and enable in vivo investigations of islet cell physiology, various experimental approaches have been developed. Especially, the recently developed imaging platforms have significantly improved the possibility to study islets at a cellular level in vivo, and provided novel insight into islet biology in health and disease. The various approaches, their applications, and reported results, as well as their limitations are reviewed in this article.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s11892-011-0207-x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1028990", 
        "issn": [
          "1534-4827", 
          "1539-0829"
        ], 
        "name": "Current Diabetes Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "11"
      }
    ], 
    "name": "Experimental Approaches for High-Resolution In Vivo Imaging of Islet of Langerhans Biology", 
    "pagination": "420", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "6a68b0a388ac6e3a4e9a4ea73f132980589344a8bd5de55f179f87e090feda17"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21701794"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101093791"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11892-011-0207-x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1022335452"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11892-011-0207-x", 
      "https://app.dimensions.ai/details/publication/pub.1022335452"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:49", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000521.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs11892-011-0207-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11892-011-0207-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11892-011-0207-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11892-011-0207-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11892-011-0207-x'


 

This table displays all metadata directly associated to this object as RDF triples.

238 TRIPLES      21 PREDICATES      82 URIs      27 LITERALS      15 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11892-011-0207-x schema:about N0fd6ff5c7168433ebb12c57a22f13b30
2 N30f6f207fdee4b56be8fac222e182532
3 N7ce03f7173774831a3213bbefd282dd4
4 N92edd7e5416c49d7890e2f7007a0e9a2
5 Nada36c57856e4f2a91b01b7f4fd7addc
6 Ne0f3f9d2c5d84468b45acd1ae590f51f
7 anzsrc-for:06
8 anzsrc-for:0601
9 schema:author N44dca8e944164a889070f5895187821c
10 schema:citation sg:pub.10.1007/s00125-009-1383-y
11 sg:pub.10.1007/s001250051322
12 sg:pub.10.1007/s00424-003-1097-9
13 sg:pub.10.1007/s11307-009-0240-1
14 sg:pub.10.1038/nm.2155
15 sg:pub.10.1038/nm1701
16 sg:pub.10.1038/nprot.2008.118
17 sg:pub.10.1038/nrendo.2009.103
18 https://app.dimensions.ai/details/publication/pub.1077746436
19 https://app.dimensions.ai/details/publication/pub.1078303131
20 https://app.dimensions.ai/details/publication/pub.1078661152
21 https://app.dimensions.ai/details/publication/pub.1083004868
22 https://doi.org/10.1002/(sici)1097-0185(199808)251:4<448::aid-ar4>3.0.co;2-o
23 https://doi.org/10.1002/aja.1001260402
24 https://doi.org/10.1002/ar.1090400204
25 https://doi.org/10.1002/ar.1091460205
26 https://doi.org/10.1016/0014-4886(87)90122-1
27 https://doi.org/10.1016/0026-2862(91)90022-4
28 https://doi.org/10.1016/j.gde.2009.07.003
29 https://doi.org/10.1016/j.mce.2004.11.002
30 https://doi.org/10.1016/s0083-6729(08)00609-2
31 https://doi.org/10.1021/bc100184w
32 https://doi.org/10.1046/j.1365-2567.1999.00826.x
33 https://doi.org/10.1096/fj.10-158121
34 https://doi.org/10.1097/00006676-199301000-00005
35 https://doi.org/10.1097/00006676-199604000-00012
36 https://doi.org/10.1097/00007890-199706150-00020
37 https://doi.org/10.1098/rsif.2005.0040
38 https://doi.org/10.1111/j.1365-2818.1994.tb03524.x
39 https://doi.org/10.1111/j.1600-065x.2008.00581.x
40 https://doi.org/10.1126/science.2321027
41 https://doi.org/10.1152/ajpendo.00321.2002
42 https://doi.org/10.1152/ajpendo.00715.2009
43 https://doi.org/10.1152/ajpendo.90544.2008
44 https://doi.org/10.1159/000055792
45 https://doi.org/10.1172/jci117228
46 https://doi.org/10.1172/jci36209
47 https://doi.org/10.1210/en.2009-1313
48 https://doi.org/10.1364/ol.31.002450
49 https://doi.org/10.1371/journal.pone.0015732
50 https://doi.org/10.1530/acta.0.0290473
51 https://doi.org/10.1679/aohc.46.315
52 https://doi.org/10.2144/03354st01
53 https://doi.org/10.2174/092986706778521940
54 https://doi.org/10.2337/db06-0232
55 https://doi.org/10.2337/db10-0205
56 https://doi.org/10.2337/diab.38.1.s199
57 schema:datePublished 2011-10
58 schema:datePublishedReg 2011-10-01
59 schema:description Under physiological conditions and in the pathogenesis of diabetes mellitus systemic influences play a substantial role for function and survival of cells of the islet of Langerhans. Therefore, in vivo studies to understand islet biology are indispensible and imaging techniques are increasingly used for this purpose. Among the diverse imaging modalities currently only laser scanning microscopy (LSM) allows resolution and visualization of individual cells and cellular processes. To overcome limited tissue penetration and working distance of LSM and enable in vivo investigations of islet cell physiology, various experimental approaches have been developed. Especially, the recently developed imaging platforms have significantly improved the possibility to study islets at a cellular level in vivo, and provided novel insight into islet biology in health and disease. The various approaches, their applications, and reported results, as well as their limitations are reviewed in this article.
60 schema:genre research_article
61 schema:inLanguage en
62 schema:isAccessibleForFree false
63 schema:isPartOf N11f677cca0824355885904403613758a
64 Ned77729c3fc04d1cb322b775d3a78eb7
65 sg:journal.1028990
66 schema:name Experimental Approaches for High-Resolution In Vivo Imaging of Islet of Langerhans Biology
67 schema:pagination 420
68 schema:productId N0cd36e36e00a4874b41fecfe94be84ff
69 N36d2729591fc4728b5a05c73b06435c5
70 N3a66ef814802470a9c5300e81bbf2a02
71 Nd28a8850dc0a434f97ae14a0c020b15c
72 Nf4d66c39e58c451ead47012ada2fe8fb
73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022335452
74 https://doi.org/10.1007/s11892-011-0207-x
75 schema:sdDatePublished 2019-04-10T20:49
76 schema:sdLicense https://scigraph.springernature.com/explorer/license/
77 schema:sdPublisher Naf802437170f4dd7a53a1e74c3bd3690
78 schema:url http://link.springer.com/10.1007%2Fs11892-011-0207-x
79 sgo:license sg:explorer/license/
80 sgo:sdDataset articles
81 rdf:type schema:ScholarlyArticle
82 N0cd36e36e00a4874b41fecfe94be84ff schema:name nlm_unique_id
83 schema:value 101093791
84 rdf:type schema:PropertyValue
85 N0fd6ff5c7168433ebb12c57a22f13b30 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Diagnostic Imaging
87 rdf:type schema:DefinedTerm
88 N11f677cca0824355885904403613758a schema:issueNumber 5
89 rdf:type schema:PublicationIssue
90 N30f6f207fdee4b56be8fac222e182532 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Insulin-Secreting Cells
92 rdf:type schema:DefinedTerm
93 N36d2729591fc4728b5a05c73b06435c5 schema:name readcube_id
94 schema:value 6a68b0a388ac6e3a4e9a4ea73f132980589344a8bd5de55f179f87e090feda17
95 rdf:type schema:PropertyValue
96 N3a66ef814802470a9c5300e81bbf2a02 schema:name dimensions_id
97 schema:value pub.1022335452
98 rdf:type schema:PropertyValue
99 N44dca8e944164a889070f5895187821c rdf:first sg:person.01336451370.12
100 rdf:rest rdf:nil
101 N7ce03f7173774831a3213bbefd282dd4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Islets of Langerhans Transplantation
103 rdf:type schema:DefinedTerm
104 N92edd7e5416c49d7890e2f7007a0e9a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Microscopy, Confocal
106 rdf:type schema:DefinedTerm
107 Nada36c57856e4f2a91b01b7f4fd7addc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Humans
109 rdf:type schema:DefinedTerm
110 Naf802437170f4dd7a53a1e74c3bd3690 schema:name Springer Nature - SN SciGraph project
111 rdf:type schema:Organization
112 Nd28a8850dc0a434f97ae14a0c020b15c schema:name pubmed_id
113 schema:value 21701794
114 rdf:type schema:PropertyValue
115 Ne0f3f9d2c5d84468b45acd1ae590f51f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Islets of Langerhans
117 rdf:type schema:DefinedTerm
118 Ned77729c3fc04d1cb322b775d3a78eb7 schema:volumeNumber 11
119 rdf:type schema:PublicationVolume
120 Nf4d66c39e58c451ead47012ada2fe8fb schema:name doi
121 schema:value 10.1007/s11892-011-0207-x
122 rdf:type schema:PropertyValue
123 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
124 schema:name Biological Sciences
125 rdf:type schema:DefinedTerm
126 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
127 schema:name Biochemistry and Cell Biology
128 rdf:type schema:DefinedTerm
129 sg:journal.1028990 schema:issn 1534-4827
130 1539-0829
131 schema:name Current Diabetes Reports
132 rdf:type schema:Periodical
133 sg:person.01336451370.12 schema:affiliation https://www.grid.ac/institutes/grid.4488.0
134 schema:familyName Speier
135 schema:givenName Stephan
136 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336451370.12
137 rdf:type schema:Person
138 sg:pub.10.1007/s00125-009-1383-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1050051160
139 https://doi.org/10.1007/s00125-009-1383-y
140 rdf:type schema:CreativeWork
141 sg:pub.10.1007/s001250051322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013383274
142 https://doi.org/10.1007/s001250051322
143 rdf:type schema:CreativeWork
144 sg:pub.10.1007/s00424-003-1097-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042328651
145 https://doi.org/10.1007/s00424-003-1097-9
146 rdf:type schema:CreativeWork
147 sg:pub.10.1007/s11307-009-0240-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046505667
148 https://doi.org/10.1007/s11307-009-0240-1
149 rdf:type schema:CreativeWork
150 sg:pub.10.1038/nm.2155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018736702
151 https://doi.org/10.1038/nm.2155
152 rdf:type schema:CreativeWork
153 sg:pub.10.1038/nm1701 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034500059
154 https://doi.org/10.1038/nm1701
155 rdf:type schema:CreativeWork
156 sg:pub.10.1038/nprot.2008.118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041033403
157 https://doi.org/10.1038/nprot.2008.118
158 rdf:type schema:CreativeWork
159 sg:pub.10.1038/nrendo.2009.103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045189479
160 https://doi.org/10.1038/nrendo.2009.103
161 rdf:type schema:CreativeWork
162 https://app.dimensions.ai/details/publication/pub.1077746436 schema:CreativeWork
163 https://app.dimensions.ai/details/publication/pub.1078303131 schema:CreativeWork
164 https://app.dimensions.ai/details/publication/pub.1078661152 schema:CreativeWork
165 https://app.dimensions.ai/details/publication/pub.1083004868 schema:CreativeWork
166 https://doi.org/10.1002/(sici)1097-0185(199808)251:4<448::aid-ar4>3.0.co;2-o schema:sameAs https://app.dimensions.ai/details/publication/pub.1018504347
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1002/aja.1001260402 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017693074
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1002/ar.1090400204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030457540
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1002/ar.1091460205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021179323
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1016/0014-4886(87)90122-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049468447
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1016/0026-2862(91)90022-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000836606
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1016/j.gde.2009.07.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000657101
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1016/j.mce.2004.11.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041274102
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1016/s0083-6729(08)00609-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005426901
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1021/bc100184w schema:sameAs https://app.dimensions.ai/details/publication/pub.1040487463
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1046/j.1365-2567.1999.00826.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035421829
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1096/fj.10-158121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030680749
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1097/00006676-199301000-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040594480
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1097/00006676-199604000-00012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022560501
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1097/00007890-199706150-00020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060276673
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1098/rsif.2005.0040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041649281
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1111/j.1365-2818.1994.tb03524.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004179064
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1111/j.1600-065x.2008.00581.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039863422
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1126/science.2321027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062532641
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1152/ajpendo.00321.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022745317
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1152/ajpendo.00715.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024942910
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1152/ajpendo.90544.2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030987262
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1159/000055792 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001431920
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1172/jci117228 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011501302
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1172/jci36209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022630398
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1210/en.2009-1313 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064250332
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1364/ol.31.002450 schema:sameAs https://app.dimensions.ai/details/publication/pub.1065224146
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1371/journal.pone.0015732 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040189065
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1530/acta.0.0290473 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052009821
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1679/aohc.46.315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032764509
225 rdf:type schema:CreativeWork
226 https://doi.org/10.2144/03354st01 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076587033
227 rdf:type schema:CreativeWork
228 https://doi.org/10.2174/092986706778521940 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069160799
229 rdf:type schema:CreativeWork
230 https://doi.org/10.2337/db06-0232 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030586992
231 rdf:type schema:CreativeWork
232 https://doi.org/10.2337/db10-0205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049342098
233 rdf:type schema:CreativeWork
234 https://doi.org/10.2337/diab.38.1.s199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070735666
235 rdf:type schema:CreativeWork
236 https://www.grid.ac/institutes/grid.4488.0 schema:alternateName TU Dresden
237 schema:name Center for Regenerative Therapies Dresden and Paul Langerhans Institute Dresden, School of Medicine, Dresden University of Technology, 01307, Dresden, Germany
238 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...