Modulation of Immune System Inhibitory Checkpoints in Colorectal Cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-12

AUTHORS

Sandip P. Patel, Takuya Osada, Koya Osada, Herbert Hurwitz, H. Kim Lyerly, Michael A. Morse

ABSTRACT

T cell infiltration of colorectal cancer is associated with improved clinical outcome, underlining the importance of the immune system in cancer control; however, immune checkpoints, including the inhibitory T cell molecules CTLA-4 and PD-1 that temper the native immune response, mitigating autoimmunity, are coopted by tumors to facilitate escape from immune surveillance. Blockade of CTLA-4 and PD-1 and its ligand PD-L1, expressed by many tumors, have shown impressive activity in melanoma, renal cell carcinoma, and lung cancer. Immune checkpoint inhibition has been less well studied in colorectal cancer, but preclinical and clinical investigations are in progress. More... »

PAGES

391-397

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11888-013-0184-3

    DOI

    http://dx.doi.org/10.1007/s11888-013-0184-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1043249223


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