Upfront Chemotherapy Regimens in Unresectable Disease: One, Two, or Three Cytotoxics? View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-09

AUTHORS

Chiara Cremolini, Fotios Loupakis, Carlotta Antoniotti, Lisa Salvatore, Marta Schirripa, Lorenzo Fornaro, Gianluca Masi, Alfredo Falcone

ABSTRACT

Today, the upfront treatment of unresectable metastatic colorectal cancer (mCRC) may span from single-agent fluoropyrimidines to three and even four-drug regimens, currently under investigation in several trials. While clinical factors, including the crucial item of secondary resectability, certainly contribute to formulate the most appropriate strategy for each patient, also molecular markers are gaining increasing prominence in the decision-making process. This review aims at collecting our group’s point of view about the role of upfront combination regimens, both in patients pursuing a radical resection and in those unlikely to undergo a secondary surgery. More... »

PAGES

153-160

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11888-012-0128-3

DOI

http://dx.doi.org/10.1007/s11888-012-0128-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051633304


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Pisa", 
          "id": "https://www.grid.ac/institutes/grid.5395.a", 
          "name": [
            "Polo Oncologico, Azienda Ospedaliera-Universitaria Pisana, Via Roma 67, 56126, Pisa, Italy", 
            "Division of Medical Oncology, Department of Oncology, Transplants and New Technologies in Medicine, University of Pisa, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cremolini", 
        "givenName": "Chiara", 
        "id": "sg:person.01257327771.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257327771.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pisa", 
          "id": "https://www.grid.ac/institutes/grid.5395.a", 
          "name": [
            "Polo Oncologico, Azienda Ospedaliera-Universitaria Pisana, Via Roma 67, 56126, Pisa, Italy", 
            "Division of Medical Oncology, Department of Oncology, Transplants and New Technologies in Medicine, University of Pisa, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Loupakis", 
        "givenName": "Fotios", 
        "id": "sg:person.01175106504.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175106504.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pisa", 
          "id": "https://www.grid.ac/institutes/grid.5395.a", 
          "name": [
            "Polo Oncologico, Azienda Ospedaliera-Universitaria Pisana, Via Roma 67, 56126, Pisa, Italy", 
            "Division of Medical Oncology, Department of Oncology, Transplants and New Technologies in Medicine, University of Pisa, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Antoniotti", 
        "givenName": "Carlotta", 
        "id": "sg:person.0656444074.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656444074.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pisa", 
          "id": "https://www.grid.ac/institutes/grid.5395.a", 
          "name": [
            "Polo Oncologico, Azienda Ospedaliera-Universitaria Pisana, Via Roma 67, 56126, Pisa, Italy", 
            "Division of Medical Oncology, Department of Oncology, Transplants and New Technologies in Medicine, University of Pisa, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Salvatore", 
        "givenName": "Lisa", 
        "id": "sg:person.01157052153.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157052153.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pisa", 
          "id": "https://www.grid.ac/institutes/grid.5395.a", 
          "name": [
            "Polo Oncologico, Azienda Ospedaliera-Universitaria Pisana, Via Roma 67, 56126, Pisa, Italy", 
            "Division of Medical Oncology, Department of Oncology, Transplants and New Technologies in Medicine, University of Pisa, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schirripa", 
        "givenName": "Marta", 
        "id": "sg:person.01225165353.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225165353.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pisa", 
          "id": "https://www.grid.ac/institutes/grid.5395.a", 
          "name": [
            "Polo Oncologico, Azienda Ospedaliera-Universitaria Pisana, Via Roma 67, 56126, Pisa, Italy", 
            "Division of Medical Oncology, Department of Oncology, Transplants and New Technologies in Medicine, University of Pisa, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fornaro", 
        "givenName": "Lorenzo", 
        "id": "sg:person.01164506727.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164506727.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pisa", 
          "id": "https://www.grid.ac/institutes/grid.5395.a", 
          "name": [
            "Polo Oncologico, Azienda Ospedaliera-Universitaria Pisana, Via Roma 67, 56126, Pisa, Italy", 
            "Division of Medical Oncology, Department of Oncology, Transplants and New Technologies in Medicine, University of Pisa, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Masi", 
        "givenName": "Gianluca", 
        "id": "sg:person.01062670207.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062670207.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pisa", 
          "id": "https://www.grid.ac/institutes/grid.5395.a", 
          "name": [
            "Polo Oncologico, Azienda Ospedaliera-Universitaria Pisana, Via Roma 67, 56126, Pisa, Italy", 
            "Division of Medical Oncology, Department of Oncology, Transplants and New Technologies in Medicine, University of Pisa, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Falcone", 
        "givenName": "Alfredo", 
        "id": "sg:person.01006230145.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006230145.44"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1200/jco.2005.05.546", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001923432"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ctrv.2011.11.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004982727"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ctrv.2011.11.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004982727"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00384-009-0655-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005226156", 
          "https://doi.org/10.1007/s00384-009-0655-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00384-009-0655-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005226156", 
          "https://doi.org/10.1007/s00384-009-0655-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.23099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005385290"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(00)02034-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006410174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6605940", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008545199", 
          "https://doi.org/10.1038/sj.bjc.6605940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm200009283431302", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010303757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.13.7471", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011463806"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-11-1965", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013287324"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/theoncologist.2011-0141", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013432328"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa032691", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014051315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejso.2008.12.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015018774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2009.27.7723", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015191602"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/theoncologist.2008-0213", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015589842"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e31819a0486", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016002497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e31819a0486", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016002497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e31819a0486", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016002497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdh470", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017702605"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2011.38.0915", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018011890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdi092", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020629434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(11)70199-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022195686"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.04.4792", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023047003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6603011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024247066", 
          "https://doi.org/10.1038/sj.bjc.6603011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6603011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024247066", 
          "https://doi.org/10.1038/sj.bjc.6603011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2009.27.4860", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024418205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2011.39.5814", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025171029"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2004.05.113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025767346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(07)61086-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026311361"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.26086", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026845205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(11)60613-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028592419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdi246", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028947330"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/14651858.cd005392.pub3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029281798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2006.09.0928", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029306962"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.14.9930", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029489307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.17.5299", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033537766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2004.11.037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034270716"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.26460", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035749683"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10868", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038374700", 
          "https://doi.org/10.1038/nature10868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1756-9966-29-58", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039017238", 
          "https://doi.org/10.1186/1756-9966-29-58"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(07)61087-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040916725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2010.30.0855", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041540340"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1103782", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041864150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.7368", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044949677"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdf034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045240563"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(07)70281-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045459552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2010.33.5091", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045522021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-8049(11)71741-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046190340"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdq632", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046321370"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.07.113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046620703"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.07.113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046620703"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(10)70175-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047103049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-010-0972-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049939887", 
          "https://doi.org/10.1245/s10434-010-0972-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-010-0972-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049939887", 
          "https://doi.org/10.1245/s10434-010-0972-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1112302", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051449373"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2011.38.4206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053193117"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2002.12.075", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203208"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2000.18.1.136", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074572224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2000.18.16.2938", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074684744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2010.28.15_suppl.3534", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083943020"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2010.28.15_suppl.3543", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083943029"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2010.28.18_suppl.cra3507", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083946794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2012.30.4_suppl.lba385", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083952922"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-09", 
    "datePublishedReg": "2012-09-01", 
    "description": "Today, the upfront treatment of unresectable metastatic colorectal cancer (mCRC) may span from single-agent fluoropyrimidines to three and even four-drug regimens, currently under investigation in several trials. While clinical factors, including the crucial item of secondary resectability, certainly contribute to formulate the most appropriate strategy for each patient, also molecular markers are gaining increasing prominence in the decision-making process. This review aims at collecting our group\u2019s point of view about the role of upfront combination regimens, both in patients pursuing a radical resection and in those unlikely to undergo a secondary surgery.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s11888-012-0128-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1035689", 
        "issn": [
          "1556-3790", 
          "1556-3804"
        ], 
        "name": "Current Colorectal Cancer Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "name": "Upfront Chemotherapy Regimens in Unresectable Disease: One, Two, or Three Cytotoxics?", 
    "pagination": "153-160", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "f5f4ca75f29cc901402db90fd1f3ba8433615dd80e6e227b7b28afe33f0ebb92"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11888-012-0128-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1051633304"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11888-012-0128-3", 
      "https://app.dimensions.ai/details/publication/pub.1051633304"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:13", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000524.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs11888-012-0128-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11888-012-0128-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11888-012-0128-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11888-012-0128-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11888-012-0128-3'


 

This table displays all metadata directly associated to this object as RDF triples.

288 TRIPLES      21 PREDICATES      84 URIs      19 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11888-012-0128-3 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author N7d59b09a0e884bf3916757d8ec0f623e
4 schema:citation sg:pub.10.1007/s00384-009-0655-9
5 sg:pub.10.1038/nature10868
6 sg:pub.10.1038/sj.bjc.6603011
7 sg:pub.10.1038/sj.bjc.6605940
8 sg:pub.10.1186/1756-9966-29-58
9 sg:pub.10.1245/s10434-010-0972-9
10 https://doi.org/10.1002/14651858.cd005392.pub3
11 https://doi.org/10.1002/bjs.7368
12 https://doi.org/10.1002/cncr.23099
13 https://doi.org/10.1002/cncr.26086
14 https://doi.org/10.1002/cncr.26460
15 https://doi.org/10.1016/j.ctrv.2011.11.002
16 https://doi.org/10.1016/j.ejso.2008.12.013
17 https://doi.org/10.1016/s0140-6736(00)02034-1
18 https://doi.org/10.1016/s0140-6736(07)61086-1
19 https://doi.org/10.1016/s0140-6736(07)61087-3
20 https://doi.org/10.1016/s0140-6736(11)60613-2
21 https://doi.org/10.1016/s0959-8049(11)71741-5
22 https://doi.org/10.1016/s1470-2045(07)70281-4
23 https://doi.org/10.1016/s1470-2045(10)70175-3
24 https://doi.org/10.1016/s1470-2045(11)70199-1
25 https://doi.org/10.1056/nejm200009283431302
26 https://doi.org/10.1056/nejmoa032691
27 https://doi.org/10.1056/nejmoa1103782
28 https://doi.org/10.1056/nejmoa1112302
29 https://doi.org/10.1093/annonc/mdf034
30 https://doi.org/10.1093/annonc/mdh470
31 https://doi.org/10.1093/annonc/mdi092
32 https://doi.org/10.1093/annonc/mdi246
33 https://doi.org/10.1093/annonc/mdq632
34 https://doi.org/10.1097/sla.0b013e31819a0486
35 https://doi.org/10.1158/1078-0432.ccr-11-1965
36 https://doi.org/10.1200/jco.2000.18.1.136
37 https://doi.org/10.1200/jco.2000.18.16.2938
38 https://doi.org/10.1200/jco.2002.12.075
39 https://doi.org/10.1200/jco.2004.05.113
40 https://doi.org/10.1200/jco.2004.11.037
41 https://doi.org/10.1200/jco.2005.04.4792
42 https://doi.org/10.1200/jco.2005.05.546
43 https://doi.org/10.1200/jco.2005.07.113
44 https://doi.org/10.1200/jco.2006.09.0928
45 https://doi.org/10.1200/jco.2007.13.7471
46 https://doi.org/10.1200/jco.2007.14.9930
47 https://doi.org/10.1200/jco.2008.17.5299
48 https://doi.org/10.1200/jco.2009.27.4860
49 https://doi.org/10.1200/jco.2009.27.7723
50 https://doi.org/10.1200/jco.2010.28.15_suppl.3534
51 https://doi.org/10.1200/jco.2010.28.15_suppl.3543
52 https://doi.org/10.1200/jco.2010.28.18_suppl.cra3507
53 https://doi.org/10.1200/jco.2010.30.0855
54 https://doi.org/10.1200/jco.2010.33.5091
55 https://doi.org/10.1200/jco.2011.38.0915
56 https://doi.org/10.1200/jco.2011.38.4206
57 https://doi.org/10.1200/jco.2011.39.5814
58 https://doi.org/10.1200/jco.2012.30.4_suppl.lba385
59 https://doi.org/10.1634/theoncologist.2008-0213
60 https://doi.org/10.1634/theoncologist.2011-0141
61 schema:datePublished 2012-09
62 schema:datePublishedReg 2012-09-01
63 schema:description Today, the upfront treatment of unresectable metastatic colorectal cancer (mCRC) may span from single-agent fluoropyrimidines to three and even four-drug regimens, currently under investigation in several trials. While clinical factors, including the crucial item of secondary resectability, certainly contribute to formulate the most appropriate strategy for each patient, also molecular markers are gaining increasing prominence in the decision-making process. This review aims at collecting our group’s point of view about the role of upfront combination regimens, both in patients pursuing a radical resection and in those unlikely to undergo a secondary surgery.
64 schema:genre research_article
65 schema:inLanguage en
66 schema:isAccessibleForFree false
67 schema:isPartOf N35c46b43183a4afa9293483a0d2b322e
68 Nd5110cf0f65d4ae1ae729d379fce04b1
69 sg:journal.1035689
70 schema:name Upfront Chemotherapy Regimens in Unresectable Disease: One, Two, or Three Cytotoxics?
71 schema:pagination 153-160
72 schema:productId N2a31367cfed14f7fbaa8c56084560068
73 N44cb956e1c9d48f7b7ce9974808e553f
74 N908ac89a66b545adba77bf9cc1917d03
75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051633304
76 https://doi.org/10.1007/s11888-012-0128-3
77 schema:sdDatePublished 2019-04-10T14:13
78 schema:sdLicense https://scigraph.springernature.com/explorer/license/
79 schema:sdPublisher N745e974ce1824bf384f7f78e700477ed
80 schema:url http://link.springer.com/10.1007%2Fs11888-012-0128-3
81 sgo:license sg:explorer/license/
82 sgo:sdDataset articles
83 rdf:type schema:ScholarlyArticle
84 N01a93708fa9148f5804e1a68b4864581 rdf:first sg:person.01225165353.57
85 rdf:rest N9a4972fc67b5438387ad30ea2f1ba4bf
86 N125f069646a8489eb9f17a1fcf7f23eb rdf:first sg:person.01157052153.90
87 rdf:rest N01a93708fa9148f5804e1a68b4864581
88 N2431c98e49794d8983234ca8bdfa934b rdf:first sg:person.01006230145.44
89 rdf:rest rdf:nil
90 N2a31367cfed14f7fbaa8c56084560068 schema:name dimensions_id
91 schema:value pub.1051633304
92 rdf:type schema:PropertyValue
93 N35c46b43183a4afa9293483a0d2b322e schema:issueNumber 3
94 rdf:type schema:PublicationIssue
95 N44cb956e1c9d48f7b7ce9974808e553f schema:name doi
96 schema:value 10.1007/s11888-012-0128-3
97 rdf:type schema:PropertyValue
98 N4936e9fd13b948a6a3ff27d7464ba3a3 rdf:first sg:person.01175106504.32
99 rdf:rest Nd9927d1670164f87abb79e450ab83e02
100 N745e974ce1824bf384f7f78e700477ed schema:name Springer Nature - SN SciGraph project
101 rdf:type schema:Organization
102 N7d59b09a0e884bf3916757d8ec0f623e rdf:first sg:person.01257327771.59
103 rdf:rest N4936e9fd13b948a6a3ff27d7464ba3a3
104 N908ac89a66b545adba77bf9cc1917d03 schema:name readcube_id
105 schema:value f5f4ca75f29cc901402db90fd1f3ba8433615dd80e6e227b7b28afe33f0ebb92
106 rdf:type schema:PropertyValue
107 N92328d366fdc44c38120766b1cce3fd3 rdf:first sg:person.01062670207.83
108 rdf:rest N2431c98e49794d8983234ca8bdfa934b
109 N9a4972fc67b5438387ad30ea2f1ba4bf rdf:first sg:person.01164506727.84
110 rdf:rest N92328d366fdc44c38120766b1cce3fd3
111 Nd5110cf0f65d4ae1ae729d379fce04b1 schema:volumeNumber 8
112 rdf:type schema:PublicationVolume
113 Nd9927d1670164f87abb79e450ab83e02 rdf:first sg:person.0656444074.77
114 rdf:rest N125f069646a8489eb9f17a1fcf7f23eb
115 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
116 schema:name Medical and Health Sciences
117 rdf:type schema:DefinedTerm
118 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
119 schema:name Oncology and Carcinogenesis
120 rdf:type schema:DefinedTerm
121 sg:journal.1035689 schema:issn 1556-3790
122 1556-3804
123 schema:name Current Colorectal Cancer Reports
124 rdf:type schema:Periodical
125 sg:person.01006230145.44 schema:affiliation https://www.grid.ac/institutes/grid.5395.a
126 schema:familyName Falcone
127 schema:givenName Alfredo
128 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006230145.44
129 rdf:type schema:Person
130 sg:person.01062670207.83 schema:affiliation https://www.grid.ac/institutes/grid.5395.a
131 schema:familyName Masi
132 schema:givenName Gianluca
133 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062670207.83
134 rdf:type schema:Person
135 sg:person.01157052153.90 schema:affiliation https://www.grid.ac/institutes/grid.5395.a
136 schema:familyName Salvatore
137 schema:givenName Lisa
138 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157052153.90
139 rdf:type schema:Person
140 sg:person.01164506727.84 schema:affiliation https://www.grid.ac/institutes/grid.5395.a
141 schema:familyName Fornaro
142 schema:givenName Lorenzo
143 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164506727.84
144 rdf:type schema:Person
145 sg:person.01175106504.32 schema:affiliation https://www.grid.ac/institutes/grid.5395.a
146 schema:familyName Loupakis
147 schema:givenName Fotios
148 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175106504.32
149 rdf:type schema:Person
150 sg:person.01225165353.57 schema:affiliation https://www.grid.ac/institutes/grid.5395.a
151 schema:familyName Schirripa
152 schema:givenName Marta
153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225165353.57
154 rdf:type schema:Person
155 sg:person.01257327771.59 schema:affiliation https://www.grid.ac/institutes/grid.5395.a
156 schema:familyName Cremolini
157 schema:givenName Chiara
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257327771.59
159 rdf:type schema:Person
160 sg:person.0656444074.77 schema:affiliation https://www.grid.ac/institutes/grid.5395.a
161 schema:familyName Antoniotti
162 schema:givenName Carlotta
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656444074.77
164 rdf:type schema:Person
165 sg:pub.10.1007/s00384-009-0655-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005226156
166 https://doi.org/10.1007/s00384-009-0655-9
167 rdf:type schema:CreativeWork
168 sg:pub.10.1038/nature10868 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038374700
169 https://doi.org/10.1038/nature10868
170 rdf:type schema:CreativeWork
171 sg:pub.10.1038/sj.bjc.6603011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024247066
172 https://doi.org/10.1038/sj.bjc.6603011
173 rdf:type schema:CreativeWork
174 sg:pub.10.1038/sj.bjc.6605940 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008545199
175 https://doi.org/10.1038/sj.bjc.6605940
176 rdf:type schema:CreativeWork
177 sg:pub.10.1186/1756-9966-29-58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039017238
178 https://doi.org/10.1186/1756-9966-29-58
179 rdf:type schema:CreativeWork
180 sg:pub.10.1245/s10434-010-0972-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049939887
181 https://doi.org/10.1245/s10434-010-0972-9
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1002/14651858.cd005392.pub3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029281798
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1002/bjs.7368 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044949677
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1002/cncr.23099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005385290
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1002/cncr.26086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026845205
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1002/cncr.26460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035749683
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1016/j.ctrv.2011.11.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004982727
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1016/j.ejso.2008.12.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015018774
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1016/s0140-6736(00)02034-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006410174
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1016/s0140-6736(07)61086-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026311361
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1016/s0140-6736(07)61087-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040916725
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1016/s0140-6736(11)60613-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028592419
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1016/s0959-8049(11)71741-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046190340
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1016/s1470-2045(07)70281-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045459552
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/s1470-2045(10)70175-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047103049
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/s1470-2045(11)70199-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022195686
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1056/nejm200009283431302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010303757
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1056/nejmoa032691 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014051315
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1056/nejmoa1103782 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041864150
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1056/nejmoa1112302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051449373
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1093/annonc/mdf034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045240563
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1093/annonc/mdh470 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017702605
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1093/annonc/mdi092 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020629434
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1093/annonc/mdi246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028947330
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1093/annonc/mdq632 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046321370
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1097/sla.0b013e31819a0486 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016002497
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1158/1078-0432.ccr-11-1965 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013287324
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1200/jco.2000.18.1.136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074572224
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1200/jco.2000.18.16.2938 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074684744
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1200/jco.2002.12.075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203208
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1200/jco.2004.05.113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025767346
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1200/jco.2004.11.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034270716
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1200/jco.2005.04.4792 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023047003
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1200/jco.2005.05.546 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001923432
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1200/jco.2005.07.113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046620703
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1200/jco.2006.09.0928 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029306962
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1200/jco.2007.13.7471 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011463806
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1200/jco.2007.14.9930 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029489307
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1200/jco.2008.17.5299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033537766
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1200/jco.2009.27.4860 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024418205
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1200/jco.2009.27.7723 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015191602
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1200/jco.2010.28.15_suppl.3534 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083943020
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1200/jco.2010.28.15_suppl.3543 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083943029
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1200/jco.2010.28.18_suppl.cra3507 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083946794
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1200/jco.2010.30.0855 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041540340
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1200/jco.2010.33.5091 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045522021
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1200/jco.2011.38.0915 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018011890
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1200/jco.2011.38.4206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053193117
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1200/jco.2011.39.5814 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025171029
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1200/jco.2012.30.4_suppl.lba385 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083952922
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1634/theoncologist.2008-0213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015589842
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1634/theoncologist.2011-0141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013432328
284 rdf:type schema:CreativeWork
285 https://www.grid.ac/institutes/grid.5395.a schema:alternateName University of Pisa
286 schema:name Division of Medical Oncology, Department of Oncology, Transplants and New Technologies in Medicine, University of Pisa, Pisa, Italy
287 Polo Oncologico, Azienda Ospedaliera-Universitaria Pisana, Via Roma 67, 56126, Pisa, Italy
288 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...