Treatment of Functional Mitral Regurgitation in Heart Failure View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-11-16

AUTHORS

Enrico Fabris, Antonio De Luca, Giancarlo Vitrella, Davide Stolfo, Marco Masè, Renata Korcova, Marco Merlo, Serena Rakar, Arnoud W. J. van’t Hof, Elvin Kedhi, Andrea Perkan, Gianfranco Sinagra

ABSTRACT

Purpose of ReviewTo analyze the current state of the art of functional mitral regurgitation (FMR) treatment.Recent FindingsThe first-line treatment of severe FMR consists of guideline medical therapy (GMT) and resynchronization therapy when indicated; the impact of new medical therapies like sacubitril/valsartan needs further assessment. Valvular intervention may be considered in FMR symptomatic patients despite GMT, and can be performed surgically or percutaneously. MitraClip is a safe percutaneous procedure associated with symptoms improvement. Recently, the COAPT trial showed superior outcomes for MitraClip versus GMT contrasting the MITRA-FR trial which showed no benefit of MitraClip compared with GMT. These results should be interpreted as complementary rather than opposite.SummaryThe COAPT trial provided a “proof of concept” that percutaneous treatment of severe FMR in patients without too advanced left ventricular disease translates into a prognostic benefit. Careful patient selection will play a critical role in defining the clinical niche for successful interventions. More... »

PAGES

139

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11886-019-1221-x

DOI

http://dx.doi.org/10.1007/s11886-019-1221-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1122657683

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31734930


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