Medical therapy in acute coronary syndromes: Which medicines and at what doses? View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-07-01

AUTHORS

Dmitriy Kireyev, Edward C. Yun, Brian J. Page, William E. Boden

ABSTRACT

Acute coronary syndrome (ACS) occurs when plaque rupture in a coronary artery is superimposed with thrombus formation. This accounts for 1.7 million hospital admissions in the United States annually and significant morbidity and mortality. Although there are advantages to an invasive approach to treating patients with ACS, the role of medical therapy is vital as an adjunctive treatment to reperfusion therapies and in stabilizing ruptured plaques and modifying the metabolic milieu that predisposes to plaque formation and rupture. This article reviews the most important drug classes for medical treatment of ACS patients, as well as optimal doses. This is an exciting time to be involved in the field of cardiovascular medicine, as we continue to see profound improvement from medical therapy in the morbidity and mortality associated with ACS. More... »

PAGES

267-275

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11886-009-0039-3

DOI

http://dx.doi.org/10.1007/s11886-009-0039-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032074867

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19563726


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Acute Coronary Syndrome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adrenergic beta-Antagonists", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Angiotensins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anticoagulants", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aspirin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibrinolytic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nitrates", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Platelet Aggregation Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Randomized Controlled Trials as Topic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stents", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "familyName": "Kireyev", 
        "givenName": "Dmitriy", 
        "id": "sg:person.0745731237.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745731237.26"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Yun", 
        "givenName": "Edward C.", 
        "type": "Person"
      }, 
      {
        "familyName": "Page", 
        "givenName": "Brian J.", 
        "id": "sg:person.01101573464.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101573464.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Cardiology, Buffalo General Hospital, 100 High Street, 14203, Buffalo, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.413119.f", 
          "name": [
            "Division of Cardiology, Buffalo General Hospital, 100 High Street, 14203, Buffalo, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boden", 
        "givenName": "William E.", 
        "id": "sg:person.01162454534.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162454534.35"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1023/a:1007858100639", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035880115", 
          "https://doi.org/10.1023/a:1007858100639"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cvm-2-3-111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022713379", 
          "https://doi.org/10.1186/cvm-2-3-111"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2009-07-01", 
    "datePublishedReg": "2009-07-01", 
    "description": "Acute coronary syndrome (ACS) occurs when plaque rupture in a coronary artery is superimposed with thrombus formation. This accounts for 1.7 million hospital admissions in the United States annually and significant morbidity and mortality. Although there are advantages to an invasive approach to treating patients with ACS, the role of medical therapy is vital as an adjunctive treatment to reperfusion therapies and in stabilizing ruptured plaques and modifying the metabolic milieu that predisposes to plaque formation and rupture. This article reviews the most important drug classes for medical treatment of ACS patients, as well as optimal doses. This is an exciting time to be involved in the field of cardiovascular medicine, as we continue to see profound improvement from medical therapy in the morbidity and mortality associated with ACS.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s11886-009-0039-3", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1021175", 
        "issn": [
          "1523-3782", 
          "1534-3170"
        ], 
        "name": "Current Cardiology Reports", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "11"
      }
    ], 
    "keywords": [
      "acute coronary syndrome", 
      "medical therapy", 
      "coronary syndrome", 
      "important drug class", 
      "reperfusion therapy", 
      "ACS patients", 
      "hospital admission", 
      "adjunctive treatment", 
      "significant morbidity", 
      "coronary artery", 
      "ruptured plaques", 
      "plaque rupture", 
      "drug classes", 
      "invasive approach", 
      "metabolic milieu", 
      "medical treatment", 
      "thrombus formation", 
      "plaque formation", 
      "optimal doses", 
      "therapy", 
      "cardiovascular medicine", 
      "morbidity", 
      "patients", 
      "syndrome", 
      "mortality", 
      "doses", 
      "profound improvement", 
      "treatment", 
      "rupture", 
      "artery", 
      "admission", 
      "plaques", 
      "United States", 
      "exciting time", 
      "medicine", 
      "milieu", 
      "role", 
      "improvement", 
      "time", 
      "formation", 
      "article", 
      "approach", 
      "state", 
      "class", 
      "advantages", 
      "field"
    ], 
    "name": "Medical therapy in acute coronary syndromes: Which medicines and at what doses?", 
    "pagination": "267-275", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1032074867"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11886-009-0039-3"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "19563726"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11886-009-0039-3", 
      "https://app.dimensions.ai/details/publication/pub.1032074867"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:21", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_486.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s11886-009-0039-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11886-009-0039-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11886-009-0039-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11886-009-0039-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11886-009-0039-3'


 

This table displays all metadata directly associated to this object as RDF triples.

181 TRIPLES      22 PREDICATES      85 URIs      75 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11886-009-0039-3 schema:about N06a646a6c4d6499cb2ed778772406997
2 N0d061a95d0574636bb15d91b28902a4b
3 N1e36349ce4fd48c9895608429e40f25e
4 N245f0f67ad3b48a5a596739f1c46a8ae
5 N35cd22915fa546b1825937cea30f0133
6 N5fa198d3f2c44f59b5fe3ca50d58b860
7 N70416f4719ab4470a4731a1c1cddcc47
8 N7714b2522e534a1f8315564d0790fdc3
9 N9d2e6dd5f9014279979f7f6b26ec8f00
10 Nb4f43986fb654ee7adf01b78941674e8
11 Nb8a0c497e0484ce2bce93929294a675a
12 Ndd7ca3f6b9d8461faecea261af23df1f
13 anzsrc-for:11
14 anzsrc-for:1102
15 schema:author Nbcc40a9ea40b4597835f431929dc2cff
16 schema:citation sg:pub.10.1023/a:1007858100639
17 sg:pub.10.1186/cvm-2-3-111
18 schema:datePublished 2009-07-01
19 schema:datePublishedReg 2009-07-01
20 schema:description Acute coronary syndrome (ACS) occurs when plaque rupture in a coronary artery is superimposed with thrombus formation. This accounts for 1.7 million hospital admissions in the United States annually and significant morbidity and mortality. Although there are advantages to an invasive approach to treating patients with ACS, the role of medical therapy is vital as an adjunctive treatment to reperfusion therapies and in stabilizing ruptured plaques and modifying the metabolic milieu that predisposes to plaque formation and rupture. This article reviews the most important drug classes for medical treatment of ACS patients, as well as optimal doses. This is an exciting time to be involved in the field of cardiovascular medicine, as we continue to see profound improvement from medical therapy in the morbidity and mortality associated with ACS.
21 schema:genre article
22 schema:inLanguage en
23 schema:isAccessibleForFree false
24 schema:isPartOf N251121464a154a16b85fe1327ef44e4b
25 Nfba670439c834f4b89cb4febb008bba4
26 sg:journal.1021175
27 schema:keywords ACS patients
28 United States
29 acute coronary syndrome
30 adjunctive treatment
31 admission
32 advantages
33 approach
34 artery
35 article
36 cardiovascular medicine
37 class
38 coronary artery
39 coronary syndrome
40 doses
41 drug classes
42 exciting time
43 field
44 formation
45 hospital admission
46 important drug class
47 improvement
48 invasive approach
49 medical therapy
50 medical treatment
51 medicine
52 metabolic milieu
53 milieu
54 morbidity
55 mortality
56 optimal doses
57 patients
58 plaque formation
59 plaque rupture
60 plaques
61 profound improvement
62 reperfusion therapy
63 role
64 rupture
65 ruptured plaques
66 significant morbidity
67 state
68 syndrome
69 therapy
70 thrombus formation
71 time
72 treatment
73 schema:name Medical therapy in acute coronary syndromes: Which medicines and at what doses?
74 schema:pagination 267-275
75 schema:productId N79d072c8fc034375a86249dfe02198e9
76 N7e7932b187f7436a9d6968a5ab511eb8
77 N943776a325a242fd850edf766b6d1259
78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032074867
79 https://doi.org/10.1007/s11886-009-0039-3
80 schema:sdDatePublished 2021-12-01T19:21
81 schema:sdLicense https://scigraph.springernature.com/explorer/license/
82 schema:sdPublisher N551b16470c314a30bbdae547e1a74014
83 schema:url https://doi.org/10.1007/s11886-009-0039-3
84 sgo:license sg:explorer/license/
85 sgo:sdDataset articles
86 rdf:type schema:ScholarlyArticle
87 N06a646a6c4d6499cb2ed778772406997 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Anticoagulants
89 rdf:type schema:DefinedTerm
90 N0d061a95d0574636bb15d91b28902a4b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Aspirin
92 rdf:type schema:DefinedTerm
93 N1e36349ce4fd48c9895608429e40f25e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Adrenergic beta-Antagonists
95 rdf:type schema:DefinedTerm
96 N245f0f67ad3b48a5a596739f1c46a8ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Enzyme Inhibitors
98 rdf:type schema:DefinedTerm
99 N251121464a154a16b85fe1327ef44e4b schema:volumeNumber 11
100 rdf:type schema:PublicationVolume
101 N2688cf95d4fc4520917630cd4c60587b rdf:first N493086dcb1a34201b6ba0cb3a459d856
102 rdf:rest N3ec4feb0a70941d1af5faf04cef29cb8
103 N35cd22915fa546b1825937cea30f0133 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Stents
105 rdf:type schema:DefinedTerm
106 N37949ca0df8847c3b008162fc8f53e1a rdf:first sg:person.01162454534.35
107 rdf:rest rdf:nil
108 N3ec4feb0a70941d1af5faf04cef29cb8 rdf:first sg:person.01101573464.76
109 rdf:rest N37949ca0df8847c3b008162fc8f53e1a
110 N493086dcb1a34201b6ba0cb3a459d856 schema:familyName Yun
111 schema:givenName Edward C.
112 rdf:type schema:Person
113 N551b16470c314a30bbdae547e1a74014 schema:name Springer Nature - SN SciGraph project
114 rdf:type schema:Organization
115 N5fa198d3f2c44f59b5fe3ca50d58b860 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Fibrinolytic Agents
117 rdf:type schema:DefinedTerm
118 N70416f4719ab4470a4731a1c1cddcc47 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Angiotensins
120 rdf:type schema:DefinedTerm
121 N7714b2522e534a1f8315564d0790fdc3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Nitrates
123 rdf:type schema:DefinedTerm
124 N79d072c8fc034375a86249dfe02198e9 schema:name pubmed_id
125 schema:value 19563726
126 rdf:type schema:PropertyValue
127 N7e7932b187f7436a9d6968a5ab511eb8 schema:name doi
128 schema:value 10.1007/s11886-009-0039-3
129 rdf:type schema:PropertyValue
130 N943776a325a242fd850edf766b6d1259 schema:name dimensions_id
131 schema:value pub.1032074867
132 rdf:type schema:PropertyValue
133 N9d2e6dd5f9014279979f7f6b26ec8f00 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Humans
135 rdf:type schema:DefinedTerm
136 Nb4f43986fb654ee7adf01b78941674e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Platelet Aggregation Inhibitors
138 rdf:type schema:DefinedTerm
139 Nb8a0c497e0484ce2bce93929294a675a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Acute Coronary Syndrome
141 rdf:type schema:DefinedTerm
142 Nbcc40a9ea40b4597835f431929dc2cff rdf:first sg:person.0745731237.26
143 rdf:rest N2688cf95d4fc4520917630cd4c60587b
144 Ndd7ca3f6b9d8461faecea261af23df1f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Randomized Controlled Trials as Topic
146 rdf:type schema:DefinedTerm
147 Nfba670439c834f4b89cb4febb008bba4 schema:issueNumber 4
148 rdf:type schema:PublicationIssue
149 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
150 schema:name Medical and Health Sciences
151 rdf:type schema:DefinedTerm
152 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
153 schema:name Cardiorespiratory Medicine and Haematology
154 rdf:type schema:DefinedTerm
155 sg:journal.1021175 schema:issn 1523-3782
156 1534-3170
157 schema:name Current Cardiology Reports
158 schema:publisher Springer Nature
159 rdf:type schema:Periodical
160 sg:person.01101573464.76 schema:familyName Page
161 schema:givenName Brian J.
162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101573464.76
163 rdf:type schema:Person
164 sg:person.01162454534.35 schema:affiliation grid-institutes:grid.413119.f
165 schema:familyName Boden
166 schema:givenName William E.
167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162454534.35
168 rdf:type schema:Person
169 sg:person.0745731237.26 schema:familyName Kireyev
170 schema:givenName Dmitriy
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745731237.26
172 rdf:type schema:Person
173 sg:pub.10.1023/a:1007858100639 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035880115
174 https://doi.org/10.1023/a:1007858100639
175 rdf:type schema:CreativeWork
176 sg:pub.10.1186/cvm-2-3-111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022713379
177 https://doi.org/10.1186/cvm-2-3-111
178 rdf:type schema:CreativeWork
179 grid-institutes:grid.413119.f schema:alternateName Division of Cardiology, Buffalo General Hospital, 100 High Street, 14203, Buffalo, NY, USA
180 schema:name Division of Cardiology, Buffalo General Hospital, 100 High Street, 14203, Buffalo, NY, USA
181 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...