Natriuretic peptides in the pathophysiology of congestive heart failure View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-05

AUTHORS

Horng H. Chen, John C. Burnett

ABSTRACT

A hallmark of congestive heart failure (CHF) is the activation of the cardiac endocrine system, in particular atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP). The natriuretic peptides are a group of structurally similar but genetically distinct peptides that have diverse actions in cardiovascular, renal, and endocrine homeostasis. ANP and BNP are of myocardial cell origin and C-type natriuretic peptide (CNP) is of endothelial origin. ANP and BNP bind to the natriuretic peptide-A receptor (NPR-A), which, via 3',5'-cyclic guanosine monophosphate (cGMP), mediates natriuresis, vasodilatation, renin inhibition, antimitogenesis, and lusitropic properties. CNP lacks natriuretic actions but possesses vasodilating and growth inhibiting actions via the guanylyl cyclase-linked natriuretic peptide-B receptor. All three peptides are cleared by the natriuretic peptide-C receptor and degraded by the ectoenzyme neutral endopeptidase 24.11, both of which are widely expressed in kidney, lung, and vascular wall. Recently, a fourth member of the natriuretic peptide, Dendroaspis natriuretic peptide (DNP) has been reported to be present in human plasma and atrial myocardium and is elevated in plasma of human CHF. More... »

PAGES

198-205

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11886-000-0069-3

DOI

http://dx.doi.org/10.1007/s11886-000-0069-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026762752

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10980893


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1116", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Physiology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Angiotensin II", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Atrial Natriuretic Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heart", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heart Failure", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Natriuresis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Natriuretic Peptide, Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Natriuretic Peptide, C-Type", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "ROC Curve", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sensitivity and Specificity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Guggenheim 9, 200 First Street SW, 55905, Rochester, MN, USA", 
          "id": "http://www.grid.ac/institutes/grid.66875.3a", 
          "name": [
            "Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Guggenheim 9, 200 First Street SW, 55905, Rochester, MN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Horng H.", 
        "id": "sg:person.01024326700.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024326700.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Guggenheim 9, 200 First Street SW, 55905, Rochester, MN, USA", 
          "id": "http://www.grid.ac/institutes/grid.66875.3a", 
          "name": [
            "Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Guggenheim 9, 200 First Street SW, 55905, Rochester, MN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Burnett", 
        "givenName": "John C.", 
        "id": "sg:person.01001266776.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001266776.01"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf00212041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001930035", 
          "https://doi.org/10.1007/bf00212041"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/378065a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015449350", 
          "https://doi.org/10.1038/378065a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2000-05", 
    "datePublishedReg": "2000-05-01", 
    "description": "A hallmark of congestive heart failure (CHF) is the activation of the cardiac endocrine system, in particular atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP). The natriuretic peptides are a group of structurally similar but genetically distinct peptides that have diverse actions in cardiovascular, renal, and endocrine homeostasis. ANP and BNP are of myocardial cell origin and C-type natriuretic peptide (CNP) is of endothelial origin. ANP and BNP bind to the natriuretic peptide-A receptor (NPR-A), which, via 3',5'-cyclic guanosine monophosphate (cGMP), mediates natriuresis, vasodilatation, renin inhibition, antimitogenesis, and lusitropic properties. CNP lacks natriuretic actions but possesses vasodilating and growth inhibiting actions via the guanylyl cyclase-linked natriuretic peptide-B receptor. All three peptides are cleared by the natriuretic peptide-C receptor and degraded by the ectoenzyme neutral endopeptidase 24.11, both of which are widely expressed in kidney, lung, and vascular wall. Recently, a fourth member of the natriuretic peptide, Dendroaspis natriuretic peptide (DNP) has been reported to be present in human plasma and atrial myocardium and is elevated in plasma of human CHF.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s11886-000-0069-3", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2384951", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2532198", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1021175", 
        "issn": [
          "1523-3782", 
          "1534-3170"
        ], 
        "name": "Current Cardiology Reports", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "2"
      }
    ], 
    "keywords": [
      "congestive heart failure", 
      "atrial natriuretic peptide", 
      "Dendroaspis natriuretic peptide", 
      "natriuretic peptide", 
      "heart failure", 
      "human congestive heart failure", 
      "cardiac endocrine system", 
      "myocardial cell origin", 
      "type natriuretic peptide", 
      "lusitropic properties", 
      "natriuretic action", 
      "renin inhibition", 
      "atrial myocardium", 
      "endocrine homeostasis", 
      "endothelial origin", 
      "vascular wall", 
      "cell origin", 
      "endocrine system", 
      "guanosine monophosphate", 
      "diverse actions", 
      "receptors", 
      "BNP", 
      "human plasma", 
      "peptides", 
      "distinct peptides", 
      "natriuresis", 
      "failure", 
      "vasodilatation", 
      "vasodilating", 
      "pathophysiology", 
      "lung", 
      "kidney", 
      "myocardium", 
      "action", 
      "antimitogenesis", 
      "plasma", 
      "inhibition", 
      "homeostasis", 
      "CNP", 
      "hallmark", 
      "activation", 
      "monophosphate", 
      "group", 
      "origin", 
      "fourth member", 
      "wall", 
      "members", 
      "growth", 
      "system", 
      "properties", 
      "particular atrial natriuretic peptide", 
      "guanylyl cyclase-linked natriuretic peptide", 
      "cyclase-linked natriuretic peptide"
    ], 
    "name": "Natriuretic peptides in the pathophysiology of congestive heart failure", 
    "pagination": "198-205", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1026762752"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11886-000-0069-3"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10980893"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11886-000-0069-3", 
      "https://app.dimensions.ai/details/publication/pub.1026762752"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:11", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_329.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s11886-000-0069-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11886-000-0069-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11886-000-0069-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11886-000-0069-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11886-000-0069-3'


 

This table displays all metadata directly associated to this object as RDF triples.

194 TRIPLES      22 PREDICATES      97 URIs      86 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11886-000-0069-3 schema:about N126ec0fb7253460799e47a47f3a70eb8
2 N1b06a37ab05743f792077da27bbd2fed
3 N2022fb55e2594ea6aba3940460673d60
4 N3944bfb1f1064a6db241af838e790461
5 N4050040bff1b42369a563adbea834248
6 N4b61aea6a5e1448baeb95698fa0f6bd7
7 N4ead5aef67724ee2a64501321fa59e6e
8 N5c61fc8f6fce4d6bafae51fac34e190b
9 N6064c58646324b6e91cc0fc632dea8f1
10 N610d7c2151484a0c8275bd678ab7a836
11 N7b51846f0ef747e893d1901ebdc4b270
12 Na97ff104bbb140b693982194c9162fbc
13 Nc6d5b1377e004adf8a3a8fc3172af4a1
14 Nce712cf3b499405cb3ce7371ff2a0d1e
15 anzsrc-for:11
16 anzsrc-for:1102
17 anzsrc-for:1116
18 schema:author N30ecb31004bb47e9a44d1000d68909f6
19 schema:citation sg:pub.10.1007/bf00212041
20 sg:pub.10.1038/378065a0
21 schema:datePublished 2000-05
22 schema:datePublishedReg 2000-05-01
23 schema:description A hallmark of congestive heart failure (CHF) is the activation of the cardiac endocrine system, in particular atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP). The natriuretic peptides are a group of structurally similar but genetically distinct peptides that have diverse actions in cardiovascular, renal, and endocrine homeostasis. ANP and BNP are of myocardial cell origin and C-type natriuretic peptide (CNP) is of endothelial origin. ANP and BNP bind to the natriuretic peptide-A receptor (NPR-A), which, via 3',5'-cyclic guanosine monophosphate (cGMP), mediates natriuresis, vasodilatation, renin inhibition, antimitogenesis, and lusitropic properties. CNP lacks natriuretic actions but possesses vasodilating and growth inhibiting actions via the guanylyl cyclase-linked natriuretic peptide-B receptor. All three peptides are cleared by the natriuretic peptide-C receptor and degraded by the ectoenzyme neutral endopeptidase 24.11, both of which are widely expressed in kidney, lung, and vascular wall. Recently, a fourth member of the natriuretic peptide, Dendroaspis natriuretic peptide (DNP) has been reported to be present in human plasma and atrial myocardium and is elevated in plasma of human CHF.
24 schema:genre article
25 schema:inLanguage en
26 schema:isAccessibleForFree false
27 schema:isPartOf N70b43bcb47b141dcbeae1ae74893bff0
28 Ndaaabbc825e7408aafd0ba2ed95845f5
29 sg:journal.1021175
30 schema:keywords BNP
31 CNP
32 Dendroaspis natriuretic peptide
33 action
34 activation
35 antimitogenesis
36 atrial myocardium
37 atrial natriuretic peptide
38 cardiac endocrine system
39 cell origin
40 congestive heart failure
41 cyclase-linked natriuretic peptide
42 distinct peptides
43 diverse actions
44 endocrine homeostasis
45 endocrine system
46 endothelial origin
47 failure
48 fourth member
49 group
50 growth
51 guanosine monophosphate
52 guanylyl cyclase-linked natriuretic peptide
53 hallmark
54 heart failure
55 homeostasis
56 human congestive heart failure
57 human plasma
58 inhibition
59 kidney
60 lung
61 lusitropic properties
62 members
63 monophosphate
64 myocardial cell origin
65 myocardium
66 natriuresis
67 natriuretic action
68 natriuretic peptide
69 origin
70 particular atrial natriuretic peptide
71 pathophysiology
72 peptides
73 plasma
74 properties
75 receptors
76 renin inhibition
77 system
78 type natriuretic peptide
79 vascular wall
80 vasodilatation
81 vasodilating
82 wall
83 schema:name Natriuretic peptides in the pathophysiology of congestive heart failure
84 schema:pagination 198-205
85 schema:productId N0947e4efdf2d472184d18e818aebc0ea
86 N94c0ef543b9f42d8ab49864f44cea644
87 Nc25d0fd879af417591261495394e2349
88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026762752
89 https://doi.org/10.1007/s11886-000-0069-3
90 schema:sdDatePublished 2022-01-01T18:11
91 schema:sdLicense https://scigraph.springernature.com/explorer/license/
92 schema:sdPublisher Nfd0686ecb7054443b86a3430122a51c0
93 schema:url https://doi.org/10.1007/s11886-000-0069-3
94 sgo:license sg:explorer/license/
95 sgo:sdDataset articles
96 rdf:type schema:ScholarlyArticle
97 N0947e4efdf2d472184d18e818aebc0ea schema:name dimensions_id
98 schema:value pub.1026762752
99 rdf:type schema:PropertyValue
100 N097a2a91123449d6af897133c8399479 rdf:first sg:person.01001266776.01
101 rdf:rest rdf:nil
102 N126ec0fb7253460799e47a47f3a70eb8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Humans
104 rdf:type schema:DefinedTerm
105 N1b06a37ab05743f792077da27bbd2fed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Signal Transduction
107 rdf:type schema:DefinedTerm
108 N2022fb55e2594ea6aba3940460673d60 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Angiotensin II
110 rdf:type schema:DefinedTerm
111 N30ecb31004bb47e9a44d1000d68909f6 rdf:first sg:person.01024326700.50
112 rdf:rest N097a2a91123449d6af897133c8399479
113 N3944bfb1f1064a6db241af838e790461 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Animals
115 rdf:type schema:DefinedTerm
116 N4050040bff1b42369a563adbea834248 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name ROC Curve
118 rdf:type schema:DefinedTerm
119 N4b61aea6a5e1448baeb95698fa0f6bd7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Natriuretic Peptide, C-Type
121 rdf:type schema:DefinedTerm
122 N4ead5aef67724ee2a64501321fa59e6e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Amino Acid Sequence
124 rdf:type schema:DefinedTerm
125 N5c61fc8f6fce4d6bafae51fac34e190b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Heart
127 rdf:type schema:DefinedTerm
128 N6064c58646324b6e91cc0fc632dea8f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Sensitivity and Specificity
130 rdf:type schema:DefinedTerm
131 N610d7c2151484a0c8275bd678ab7a836 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Natriuretic Peptide, Brain
133 rdf:type schema:DefinedTerm
134 N70b43bcb47b141dcbeae1ae74893bff0 schema:volumeNumber 2
135 rdf:type schema:PublicationVolume
136 N7b51846f0ef747e893d1901ebdc4b270 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Prognosis
138 rdf:type schema:DefinedTerm
139 N94c0ef543b9f42d8ab49864f44cea644 schema:name doi
140 schema:value 10.1007/s11886-000-0069-3
141 rdf:type schema:PropertyValue
142 Na97ff104bbb140b693982194c9162fbc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Heart Failure
144 rdf:type schema:DefinedTerm
145 Nc25d0fd879af417591261495394e2349 schema:name pubmed_id
146 schema:value 10980893
147 rdf:type schema:PropertyValue
148 Nc6d5b1377e004adf8a3a8fc3172af4a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Atrial Natriuretic Factor
150 rdf:type schema:DefinedTerm
151 Nce712cf3b499405cb3ce7371ff2a0d1e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Natriuresis
153 rdf:type schema:DefinedTerm
154 Ndaaabbc825e7408aafd0ba2ed95845f5 schema:issueNumber 3
155 rdf:type schema:PublicationIssue
156 Nfd0686ecb7054443b86a3430122a51c0 schema:name Springer Nature - SN SciGraph project
157 rdf:type schema:Organization
158 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
159 schema:name Medical and Health Sciences
160 rdf:type schema:DefinedTerm
161 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
162 schema:name Cardiorespiratory Medicine and Haematology
163 rdf:type schema:DefinedTerm
164 anzsrc-for:1116 schema:inDefinedTermSet anzsrc-for:
165 schema:name Medical Physiology
166 rdf:type schema:DefinedTerm
167 sg:grant.2384951 http://pending.schema.org/fundedItem sg:pub.10.1007/s11886-000-0069-3
168 rdf:type schema:MonetaryGrant
169 sg:grant.2532198 http://pending.schema.org/fundedItem sg:pub.10.1007/s11886-000-0069-3
170 rdf:type schema:MonetaryGrant
171 sg:journal.1021175 schema:issn 1523-3782
172 1534-3170
173 schema:name Current Cardiology Reports
174 schema:publisher Springer Nature
175 rdf:type schema:Periodical
176 sg:person.01001266776.01 schema:affiliation grid-institutes:grid.66875.3a
177 schema:familyName Burnett
178 schema:givenName John C.
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001266776.01
180 rdf:type schema:Person
181 sg:person.01024326700.50 schema:affiliation grid-institutes:grid.66875.3a
182 schema:familyName Chen
183 schema:givenName Horng H.
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024326700.50
185 rdf:type schema:Person
186 sg:pub.10.1007/bf00212041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001930035
187 https://doi.org/10.1007/bf00212041
188 rdf:type schema:CreativeWork
189 sg:pub.10.1038/378065a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015449350
190 https://doi.org/10.1038/378065a0
191 rdf:type schema:CreativeWork
192 grid-institutes:grid.66875.3a schema:alternateName Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Guggenheim 9, 200 First Street SW, 55905, Rochester, MN, USA
193 schema:name Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Guggenheim 9, 200 First Street SW, 55905, Rochester, MN, USA
194 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...