The Obese Brain—Effects of Bariatric Surgery on Energy Balance Neurocircuitry View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-10

AUTHORS

José Carlos de Lima-Júnior, Lício A. Velloso, Bruno Geloneze

ABSTRACT

Obesity is a highly prevalent disease in the world and with a major impact on global health. While genetic components are also involved in its pathogenesis, in recent years, it has shown a critical role of the innate and adaptive immune cell response in many tissues triggered by excess of nutrients such as lipids and glucose. Free fatty acids and other nutrient-related signals induce damage such as insulin resistance in the peripheral tissues but also in the brain. Specifically in the hypothalamus, these metabolic signals can trigger significant changes in the control of energy balance. Recent studies have shown that saturated fat disrupts melanocortin signaling of hypothalamic neuronal subgroups pivotal to energy control. Bariatric surgery is a treatment option for obesity when other tools have failed, because it is more effective than pharmacotherapy concerning of weight loss itself and in improvement of obesity-related comorbidities. Here, we review the mechanisms by which Roux-en Y gastric bypass (RYGB) can change peripheral signals that modulate melanocortin circuits involved in the regulation of energy balance. More... »

PAGES

57

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11883-015-0536-3

    DOI

    http://dx.doi.org/10.1007/s11883-015-0536-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1025426237

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26300554


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