The Obese Brain—Effects of Bariatric Surgery on Energy Balance Neurocircuitry View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-10

AUTHORS

José Carlos de Lima-Júnior, Lício A. Velloso, Bruno Geloneze

ABSTRACT

Obesity is a highly prevalent disease in the world and with a major impact on global health. While genetic components are also involved in its pathogenesis, in recent years, it has shown a critical role of the innate and adaptive immune cell response in many tissues triggered by excess of nutrients such as lipids and glucose. Free fatty acids and other nutrient-related signals induce damage such as insulin resistance in the peripheral tissues but also in the brain. Specifically in the hypothalamus, these metabolic signals can trigger significant changes in the control of energy balance. Recent studies have shown that saturated fat disrupts melanocortin signaling of hypothalamic neuronal subgroups pivotal to energy control. Bariatric surgery is a treatment option for obesity when other tools have failed, because it is more effective than pharmacotherapy concerning of weight loss itself and in improvement of obesity-related comorbidities. Here, we review the mechanisms by which Roux-en Y gastric bypass (RYGB) can change peripheral signals that modulate melanocortin circuits involved in the regulation of energy balance. More... »

PAGES

57

References to SciGraph publications

  • 2011-12. Altered hypothalamic function in diet-induced obesity in INTERNATIONAL JOURNAL OF OBESITY
  • 2014-03. Altered brain activity in severely obese women may recover after Roux-en Y gastric bypass surgery in INTERNATIONAL JOURNAL OF OBESITY
  • 2003-02. STAT3 signalling is required for leptin regulation of energy balance but not reproduction in NATURE
  • 2000-04. Central nervous system control of food intake in NATURE
  • 2015-08. Cognitive and autonomic determinants of energy homeostasis in obesity in NATURE REVIEWS ENDOCRINOLOGY
  • 2013-11. Gut hormones, early dumping and resting energy expenditure in patients with good and poor weight loss response after Roux-en-Y gastric bypass in INTERNATIONAL JOURNAL OF OBESITY
  • 2013-09. Improvement in hepatic insulin sensitivity after Roux-en-Y gastric bypass in a rat model of obesity is partially mediated via hypothalamic insulin action in DIABETOLOGIA
  • 2015-05. Leptin deficient ob/ob mice and diet-induced obese mice responded differently to Roux-en-Y bypass surgery in INTERNATIONAL JOURNAL OF OBESITY
  • 1994-12. Positional cloning of the mouse obese gene and its human homologue in NATURE
  • 2015-10. Distinct regulation of hypothalamic and brown/beige adipose tissue activities in human obesity in INTERNATIONAL JOURNAL OF OBESITY
  • 2008-06. Long-term Weight Regain after Gastric Bypass: A 5-year Prospective Study in OBESITY SURGERY
  • 2015-02. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance in NATURE MEDICINE
  • 2010-01. The Gut Hormone Response Following Roux-en-Y Gastric Bypass: Cross-sectional and Prospective Study in OBESITY SURGERY
  • 2001-12. Serum Leptin Levels After Bariatric Surgery Across a Range of Glucose Tolerance from Normal to Diabetes in OBESITY SURGERY
  • 2001-10. Intracellular signalling: Key enzyme in leptin-induced anorexia in NATURE
  • 2009-07. Prospective study of gut hormone and metabolic changes after adjustable gastric banding and Roux-en-Y gastric bypass in INTERNATIONAL JOURNAL OF OBESITY
  • 2005-05. Anatomy and regulation of the central melanocortin system in NATURE NEUROSCIENCE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11883-015-0536-3

    DOI

    http://dx.doi.org/10.1007/s11883-015-0536-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1025426237

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26300554


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