Ontology type: schema:ScholarlyArticle
2006-03
AUTHORSHae-Sim Park, Seung-Hyun Kim, Choon-Sik Park
ABSTRACTMajor progress has been made during the past few years in developing a better understanding of the genetic basis of asthma, which has led to the identification of several chromosomal regions and loci showing linkage to and association with asthma and asthma-related phenotypes. Recent positional cloning approaches have also been informative in identifying several strong candidate genes for asthma. As another approach, association studies between candidate gene polymorphisms and asthma-related phenotypes have been conducted in many areas and replicated in different ethnic groups. These approaches need to be followed by validation processes to confirm their functional relevance in the pathophysiology of asthma. In this review, we describe several novel genes, including ADAM33, ADRB2, and eotaxin, that modify airway responsiveness in asthmatic patients. More... »
PAGES112
http://scigraph.springernature.com/pub.10.1007/s11882-006-0048-x
DOIhttp://dx.doi.org/10.1007/s11882-006-0048-x
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1022601784
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/16566860
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Genetics",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Cardiorespiratory Medicine and Haematology",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "ADAM Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Asthma",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Bronchial Hyperreactivity",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Chemokine CCL11",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Chemokines, CC",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Genetic Predisposition to Disease",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Phenotype",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Polymorphism, Genetic",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Receptors, Adrenergic, beta-2",
"type": "DefinedTerm"
}
],
"author": [
{
"familyName": "Park",
"givenName": "Hae-Sim",
"id": "sg:person.010200047735.02",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010200047735.02"
],
"type": "Person"
},
{
"familyName": "Kim",
"givenName": "Seung-Hyun",
"id": "sg:person.01255615162.64",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255615162.64"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Allergy and Respiratory Medicine, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Jung Dong Wonmi Gu, Bucheon, Kyonggi Do, Korea",
"id": "http://www.grid.ac/institutes/grid.412678.e",
"name": [
"Division of Allergy and Respiratory Medicine, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Jung Dong Wonmi Gu, Bucheon, Kyonggi Do, Korea"
],
"type": "Organization"
},
"familyName": "Park",
"givenName": "Choon-Sik",
"id": "sg:person.012407066254.74",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012407066254.74"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1007/s11882-005-0082-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021438567",
"https://doi.org/10.1007/s11882-005-0082-0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00281-003-0153-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046707226",
"https://doi.org/10.1007/s00281-003-0153-z"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng0501-87",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030529574",
"https://doi.org/10.1038/ng0501-87"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature00878",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000571676",
"https://doi.org/10.1038/nature00878"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1465-9921-4-14",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043096595",
"https://doi.org/10.1186/1465-9921-4-14"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng1256",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010334841",
"https://doi.org/10.1038/ng1256"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng1166",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007396598",
"https://doi.org/10.1038/ng1166"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.2165/00129785-200101030-00002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009087415",
"https://doi.org/10.2165/00129785-200101030-00002"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng1153",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052769945",
"https://doi.org/10.1038/ng1153"
],
"type": "CreativeWork"
}
],
"datePublished": "2006-03",
"datePublishedReg": "2006-03-01",
"description": "Major progress has been made during the past few years in developing a better understanding of the genetic basis of asthma, which has led to the identification of several chromosomal regions and loci showing linkage to and association with asthma and asthma-related phenotypes. Recent positional cloning approaches have also been informative in identifying several strong candidate genes for asthma. As another approach, association studies between candidate gene polymorphisms and asthma-related phenotypes have been conducted in many areas and replicated in different ethnic groups. These approaches need to be followed by validation processes to confirm their functional relevance in the pathophysiology of asthma. In this review, we describe several novel genes, including ADAM33, ADRB2, and eotaxin, that modify airway responsiveness in asthmatic patients.",
"genre": "article",
"id": "sg:pub.10.1007/s11882-006-0048-x",
"inLanguage": "en",
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1029244",
"issn": [
"1529-7322",
"1534-6315"
],
"name": "Current Allergy and Asthma Reports",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "2",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "6"
}
],
"keywords": [
"asthma-related phenotypes",
"pathophysiology of asthma",
"candidate gene polymorphisms",
"airway responsiveness",
"airway responses",
"asthmatic patients",
"asthma",
"gene polymorphisms",
"different ethnic groups",
"functional relevance",
"strong candidate gene",
"ethnic groups",
"association studies",
"phenotype",
"eotaxin",
"patients",
"candidate genes",
"pathophysiology",
"novel genes",
"major progress",
"ADRB2",
"ADAM33",
"genes",
"responsiveness",
"genetic basis",
"association",
"chromosomal regions",
"better understanding",
"polymorphism",
"group",
"review",
"years",
"response",
"positional cloning approach",
"study",
"role",
"relevance",
"identification",
"validation process",
"cloning approach",
"area",
"approach",
"progress",
"understanding",
"loci",
"basis",
"region",
"linkage",
"process"
],
"name": "The role of novel genes in modifying airway responses in asthma",
"pagination": "112",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1022601784"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s11882-006-0048-x"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"16566860"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s11882-006-0048-x",
"https://app.dimensions.ai/details/publication/pub.1022601784"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-10T09:55",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/article/article_430.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/s11882-006-0048-x"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11882-006-0048-x'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11882-006-0048-x'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11882-006-0048-x'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11882-006-0048-x'
This table displays all metadata directly associated to this object as RDF triples.
211 TRIPLES
22 PREDICATES
98 URIs
79 LITERALS
18 BLANK NODES