Hematopoietic stem cell transplantation for severe combined immune deficiency View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-09

AUTHORS

Kenneth I. Weinberg, Neena Kapoor, Ami J. Shah, Gay M. Crooks, Donald B. Kohn, Robertson Parkman

ABSTRACT

Hematopoietic stem cell transplantation (HSCT) has been the definitive therapy for severe combined immune deficiency (SCID) since the first successful transplant for SCID in 1968. Improvements in the use of HSCT to treat patients with SCID are continuing. For example, during the last 5 years, the first successful in-utero HSCT, and the first success with gene therapy have occurred in patients with SCID. Debate still continues about the role of pretransplantation therapy for SCID patients, and the biology of post-HSCT immune reconstitution is under investigation. More... »

PAGES

416-420

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11882-001-0026-2

DOI

http://dx.doi.org/10.1007/s11882-001-0026-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044875434

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11892067


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48 schema:description Hematopoietic stem cell transplantation (HSCT) has been the definitive therapy for severe combined immune deficiency (SCID) since the first successful transplant for SCID in 1968. Improvements in the use of HSCT to treat patients with SCID are continuing. For example, during the last 5 years, the first successful in-utero HSCT, and the first success with gene therapy have occurred in patients with SCID. Debate still continues about the role of pretransplantation therapy for SCID patients, and the biology of post-HSCT immune reconstitution is under investigation.
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