Antibody-Drug Conjugates in Breast Cancer: a Comprehensive Review View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-05

AUTHORS

Noam Pondé, Philippe Aftimos, Martine Piccart

ABSTRACT

OPINION STATEMENT: Antibody-drug conjugates are an elegant approach to cancer treatment that couples the specificity of monoclonal antibodies to the cytotoxicity of classic chemotherapy agents, permitting, at least in theory, increased activity and reduced toxicity. In breast cancer, the early success of trastuzumab-emtansine (T-DM1) in the HER2-positive metastatic setting led to great hopes, later dashed by results in the early setting (KRISTINE trial) and in combination with pertuzumab (MARIANNE trial). Parallel to this, development of ADCs in breast cancer has suffered other setbacks, including the recent failure of other agents (MM-302) as well as the suspension of a few programs (XMT-1522, ADCT-502) with the overall effect of dampening the impetus of this concept and halting/delaying the progress of drugs associated with it, particularly when immunotherapy is at the center of so many efforts. Numerous antibody-drug conjugates remain, however, in development, and could prove successful. Critically, ADCs could permit the introduction of novel concepts such as the expansion of potent anti-HER2 therapy to HER2-low breast cancer, treatment beyond resistance to T-DM1, and synergy in combination with immune checkpoint blockade. In the early setting, the ATEMPT trial may show that T-DM1 reduces toxicity while maintaining good outcomes for lower risk HER2+ patients. ADCs based on bispecific antibodies are also in development. Finally, breakthroughs are occurring in the orphan triple-negative breast cancer subtype with agents targeting surface proteins. The recent results of Sacituzumab govitecan suggest substantial activity in heavily pre-treated patients and underscore the enduring relevance of antibody drug conjugates as a path towards better outcomes. More... »

PAGES

37

References to SciGraph publications

  • 2007-07. The Emerging Role of the LIV-1 Subfamily of Zinc Transporters in Breast Cancer in MOLECULAR MEDICINE
  • 2015-10. Activity of T-DM1 in Her2-positive breast cancer brain metastases in CLINICAL & EXPERIMENTAL METASTASIS
  • 2015-11. Evolving Strategies for Target Selection for Antibody-Drug Conjugates in PHARMACEUTICAL RESEARCH
  • 1999-04. Inhibitory effects of combinations of HER-2/neu antibody and chemotherapeutic agents used for treatment of human breast cancers in ONCOGENE
  • 2016-12. HERMIONE: a randomized Phase 2 trial of MM-302 plus trastuzumab versus chemotherapy of physician’s choice plus trastuzumab in patients with previously treated, anthracycline-naïve, HER2-positive, locally advanced/metastatic breast cancer in BMC CANCER
  • 2017-12-05. Antibody drug conjugates and bystander killing: is antigen-dependent internalisation required? in BRITISH JOURNAL OF CANCER
  • 2015-08. A novel humanized anti-HER2 antibody conjugated with MMAE exerts potent anti-tumor activity in BREAST CANCER RESEARCH AND TREATMENT
  • 2015-10. GPNMB cooperates with neuropilin-1 to promote mammary tumor growth and engages integrin α5β1 for efficient breast cancer metastasis in ONCOGENE
  • 2018-02. Clinical toxicity of antibody drug conjugates: a meta-analysis of payloads in INVESTIGATIONAL NEW DRUGS
  • 2015-03. Antibody Drug Conjugates: Design and Selection of Linker, Payload and Conjugation Chemistry in THE AAPS JOURNAL
  • 2017-09. A Mechanism-Based PK/PD Model for Hematological Toxicities Induced by Antibody-Drug Conjugates in THE AAPS JOURNAL
  • 2018. Immune Checkpoint Blockade for Breast Cancer in OPTIMIZING BREAST CANCER MANAGEMENT
  • 2017-03-17. Strategies and challenges for the next generation of antibody–drug conjugates in NATURE REVIEWS DRUG DISCOVERY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11864-019-0633-6

    DOI

    http://dx.doi.org/10.1007/s11864-019-0633-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113162616

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30931493


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "AC Camargo Hospital", 
              "id": "https://www.grid.ac/institutes/grid.413320.7", 
              "name": [
                "Department of Research, Institut Jules Bordet; Universit\u00e9 Libre de Bruxelles, Boulevard de Waterloo, 121 1000, Brussels, Belgium", 
                "AC Camargo Cancer Center, Medical Oncology Department, Sao Paulo, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pond\u00e9", 
            "givenName": "Noam", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Research, Institut Jules Bordet; Universit\u00e9 Libre de Bruxelles, Boulevard de Waterloo, 121 1000, Brussels, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Aftimos", 
            "givenName": "Philippe", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Research, Institut Jules Bordet; Universit\u00e9 Libre de Bruxelles, Boulevard de Waterloo, 121 1000, Brussels, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Piccart", 
            "givenName": "Martine", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/sj.onc.1202526", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001624052", 
              "https://doi.org/10.1038/sj.onc.1202526"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1202526", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001624052", 
              "https://doi.org/10.1038/sj.onc.1202526"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-13-0896", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005457467"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10585-015-9740-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007579842", 
              "https://doi.org/10.1007/s10585-015-9740-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.30276", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009346679"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2012.44.9694", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011125550"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2016.67.4887", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011138111"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2016.67.4887", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011138111"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2967/jnumed.115.157941", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013958453"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11095-015-1624-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013990430", 
              "https://doi.org/10.1007/s11095-015-1624-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-15-2499", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017320489"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.29210", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018963471"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cncr.28465", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019733278"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12885-016-2385-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020233811", 
              "https://doi.org/10.1186/s12885-016-2385-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12885-016-2385-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020233811", 
              "https://doi.org/10.1186/s12885-016-2385-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0305-7372(78)80014-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020712865"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(14)70178-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022501322"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-15-0188", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023777675"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1208/s12248-014-9710-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024929155", 
              "https://doi.org/10.1208/s12248-014-9710-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm500766w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026892692"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fimmu.2015.00501", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027056417"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-pharmtox-011112-140226", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028992563"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-15-0695", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030606964"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.taap.2012.04.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030670713"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1113205", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031166230"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdu486", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033160518"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000421-198504000-00007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033873771"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000421-198504000-00007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033873771"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/cshperspect.a009159", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034012783"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molonc.2016.07.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037698101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2015.8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037965589", 
              "https://doi.org/10.1038/onc.2015.8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-14-0881-t", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038702474"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2011.40.5902", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039292872"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2010.29.5865", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039297182"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-015-3503-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040244288", 
              "https://doi.org/10.1007/s10549-015-3503-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scitranslmed.aac4925", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040733977"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccell.2015.12.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042708318"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1209124", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042743567"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-09-1611", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043201205"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1413513", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043562849"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2009.26.2071", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044811338"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2014.56.2959", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046908172"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2013.52.5683", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050776713"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/cb500116c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055226626"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdv577", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059394619"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdw424", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059394853"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scitranslmed.aag2611", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062689221"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1538-7445.am2015-ct234", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063265076"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2119/2007-00040.taylor", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1068965003", 
              "https://doi.org/10.2119/2007-00040.taylor"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2119/2007-00040.taylor", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1068965003", 
              "https://doi.org/10.2119/2007-00040.taylor"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2119/2007-00040.taylor", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1068965003", 
              "https://doi.org/10.2119/2007-00040.taylor"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/doi: 10.4415/ann_13_02_07", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078744301"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2014.32.26_suppl.153", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083397480"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd.2016.268", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084129613", 
              "https://doi.org/10.1038/nrd.2016.268"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2016.70.8297", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084253732"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(17)30313-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085422217"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(17)30312-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085423138"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.pharmthera.2017.05.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085562865"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cncr.30789", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085722415"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1703643", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085866538"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1208/s12248-017-0113-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1086146859", 
              "https://doi.org/10.1208/s12248-017-0113-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1208/s12248-017-0113-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1086146859", 
              "https://doi.org/10.1208/s12248-017-0113-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdx541", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091867037"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10637-017-0520-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092192646", 
              "https://doi.org/10.1007/s10637-017-0520-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2017.367", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092352159", 
              "https://doi.org/10.1038/bjc.2017.367"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(17)30717-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092667029"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(17)30716-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092997796"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2217/fon-2017-0336", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1093059121"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-319-70197-4_10", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100469421", 
              "https://doi.org/10.1007/978-3-319-70197-4_10"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1538-7445.sabcs17-pd3-14", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101066253"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.aar4060", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101698084"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ctrv.2018.04.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103765823"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.25615", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105076727"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2018.36.15_suppl.1004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106714027"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2018.36.15_suppl.1028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106714134"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2018.36.15_suppl.1030", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106714137"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2018.36.15_suppl.2546", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106714722"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2018.36.15_suppl.506", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106715249"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2016.34.15_suppl.607", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106842296"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2017.35.15_suppl.108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106845762"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2017.35.15_suppl.2511", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106846154"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1809615", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107740741"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1809615", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107740741"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(18)30812-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1112068666"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(18)30812-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1112068666"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(18)30812-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1112068666"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(18)30812-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1112068666"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1814213", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1112259240"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1814213", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1112259240"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1814213", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1112259240"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-05", 
        "datePublishedReg": "2019-05-01", 
        "description": "OPINION STATEMENT: Antibody-drug conjugates are an elegant approach to cancer treatment that couples the specificity of monoclonal antibodies to the cytotoxicity of classic chemotherapy agents, permitting, at least in theory, increased activity and reduced toxicity. In breast cancer, the early success of trastuzumab-emtansine (T-DM1) in the HER2-positive metastatic setting led to great hopes, later dashed by results in the early setting (KRISTINE trial) and in combination with pertuzumab (MARIANNE trial). Parallel to this, development of ADCs in breast cancer has suffered other setbacks, including the recent failure of other agents (MM-302) as well as the suspension of a few programs (XMT-1522, ADCT-502) with the overall effect of dampening the impetus of this concept and halting/delaying the progress of drugs associated with it, particularly when immunotherapy is at the center of so many efforts. Numerous antibody-drug conjugates remain, however, in development, and could prove successful. Critically, ADCs could permit the introduction of novel concepts such as the expansion of potent anti-HER2 therapy to HER2-low breast cancer, treatment beyond resistance to T-DM1, and synergy in combination with immune checkpoint blockade. In the early setting, the ATEMPT trial may show that T-DM1 reduces toxicity while maintaining good outcomes for lower risk HER2+ patients. ADCs based on bispecific antibodies are also in development. Finally, breakthroughs are occurring in the orphan triple-negative breast cancer subtype with agents targeting surface proteins. The recent results of Sacituzumab govitecan suggest substantial activity in heavily pre-treated patients and underscore the enduring relevance of antibody drug conjugates as a path towards better outcomes.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s11864-019-0633-6", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1022080", 
            "issn": [
              "1527-2729", 
              "1534-6277"
            ], 
            "name": "Current Treatment Options in Oncology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "5", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "20"
          }
        ], 
        "name": "Antibody-Drug Conjugates in Breast Cancer: a Comprehensive Review", 
        "pagination": "37", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "491845350ba437046d2648f74d2be6f5b2da57ce24341007b9ab72e6cd20350f"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30931493"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "100900946"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s11864-019-0633-6"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1113162616"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s11864-019-0633-6", 
          "https://app.dimensions.ai/details/publication/pub.1113162616"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T14:16", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000372_0000000372/records_117087_00000003.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1007%2Fs11864-019-0633-6"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11864-019-0633-6'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11864-019-0633-6'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11864-019-0633-6'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11864-019-0633-6'


     

    This table displays all metadata directly associated to this object as RDF triples.

    329 TRIPLES      21 PREDICATES      106 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s11864-019-0633-6 schema:about anzsrc-for:11
    2 anzsrc-for:1112
    3 schema:author Nc7b1fde001d649109831c71ecbbed855
    4 schema:citation sg:pub.10.1007/978-3-319-70197-4_10
    5 sg:pub.10.1007/s10549-015-3503-3
    6 sg:pub.10.1007/s10585-015-9740-3
    7 sg:pub.10.1007/s10637-017-0520-6
    8 sg:pub.10.1007/s11095-015-1624-3
    9 sg:pub.10.1038/bjc.2017.367
    10 sg:pub.10.1038/nrd.2016.268
    11 sg:pub.10.1038/onc.2015.8
    12 sg:pub.10.1038/sj.onc.1202526
    13 sg:pub.10.1186/s12885-016-2385-z
    14 sg:pub.10.1208/s12248-014-9710-8
    15 sg:pub.10.1208/s12248-017-0113-5
    16 sg:pub.10.2119/2007-00040.taylor
    17 https://doi.org/10.1002/cncr.28465
    18 https://doi.org/10.1002/cncr.30789
    19 https://doi.org/10.1002/ijc.29210
    20 https://doi.org/10.1002/ijc.30276
    21 https://doi.org/10.1016/j.ccell.2015.12.008
    22 https://doi.org/10.1016/j.ctrv.2018.04.016
    23 https://doi.org/10.1016/j.molonc.2016.07.002
    24 https://doi.org/10.1016/j.pharmthera.2017.05.010
    25 https://doi.org/10.1016/j.taap.2012.04.008
    26 https://doi.org/10.1016/s0305-7372(78)80014-0
    27 https://doi.org/10.1016/s1470-2045(14)70178-0
    28 https://doi.org/10.1016/s1470-2045(17)30312-1
    29 https://doi.org/10.1016/s1470-2045(17)30313-3
    30 https://doi.org/10.1016/s1470-2045(17)30716-7
    31 https://doi.org/10.1016/s1470-2045(17)30717-9
    32 https://doi.org/10.1016/s1470-2045(18)30812-x
    33 https://doi.org/10.1021/cb500116c
    34 https://doi.org/10.1021/jm500766w
    35 https://doi.org/10.1056/nejmoa1113205
    36 https://doi.org/10.1056/nejmoa1209124
    37 https://doi.org/10.1056/nejmoa1413513
    38 https://doi.org/10.1056/nejmoa1703643
    39 https://doi.org/10.1056/nejmoa1809615
    40 https://doi.org/10.1056/nejmoa1814213
    41 https://doi.org/10.1093/annonc/mdu486
    42 https://doi.org/10.1093/annonc/mdv577
    43 https://doi.org/10.1093/annonc/mdw424
    44 https://doi.org/10.1093/annonc/mdx541
    45 https://doi.org/10.1097/00000421-198504000-00007
    46 https://doi.org/10.1101/cshperspect.a009159
    47 https://doi.org/10.1126/science.aar4060
    48 https://doi.org/10.1126/scitranslmed.aac4925
    49 https://doi.org/10.1126/scitranslmed.aag2611
    50 https://doi.org/10.1146/annurev-pharmtox-011112-140226
    51 https://doi.org/10.1158/1078-0432.ccr-09-1611
    52 https://doi.org/10.1158/1078-0432.ccr-15-0695
    53 https://doi.org/10.1158/1078-0432.ccr-15-2499
    54 https://doi.org/10.1158/1535-7163.mct-13-0896
    55 https://doi.org/10.1158/1535-7163.mct-14-0881-t
    56 https://doi.org/10.1158/1535-7163.mct-15-0188
    57 https://doi.org/10.1158/1538-7445.am2015-ct234
    58 https://doi.org/10.1158/1538-7445.sabcs17-pd3-14
    59 https://doi.org/10.1200/jco.2009.26.2071
    60 https://doi.org/10.1200/jco.2010.29.5865
    61 https://doi.org/10.1200/jco.2011.40.5902
    62 https://doi.org/10.1200/jco.2012.44.9694
    63 https://doi.org/10.1200/jco.2013.52.5683
    64 https://doi.org/10.1200/jco.2014.32.26_suppl.153
    65 https://doi.org/10.1200/jco.2014.56.2959
    66 https://doi.org/10.1200/jco.2016.34.15_suppl.607
    67 https://doi.org/10.1200/jco.2016.67.4887
    68 https://doi.org/10.1200/jco.2016.70.8297
    69 https://doi.org/10.1200/jco.2017.35.15_suppl.108
    70 https://doi.org/10.1200/jco.2017.35.15_suppl.2511
    71 https://doi.org/10.1200/jco.2018.36.15_suppl.1004
    72 https://doi.org/10.1200/jco.2018.36.15_suppl.1028
    73 https://doi.org/10.1200/jco.2018.36.15_suppl.1030
    74 https://doi.org/10.1200/jco.2018.36.15_suppl.2546
    75 https://doi.org/10.1200/jco.2018.36.15_suppl.506
    76 https://doi.org/10.18632/oncotarget.25615
    77 https://doi.org/10.2217/fon-2017-0336
    78 https://doi.org/10.2967/jnumed.115.157941
    79 https://doi.org/10.3389/fimmu.2015.00501
    80 https://doi.org/doi: 10.4415/ann_13_02_07
    81 schema:datePublished 2019-05
    82 schema:datePublishedReg 2019-05-01
    83 schema:description OPINION STATEMENT: Antibody-drug conjugates are an elegant approach to cancer treatment that couples the specificity of monoclonal antibodies to the cytotoxicity of classic chemotherapy agents, permitting, at least in theory, increased activity and reduced toxicity. In breast cancer, the early success of trastuzumab-emtansine (T-DM1) in the HER2-positive metastatic setting led to great hopes, later dashed by results in the early setting (KRISTINE trial) and in combination with pertuzumab (MARIANNE trial). Parallel to this, development of ADCs in breast cancer has suffered other setbacks, including the recent failure of other agents (MM-302) as well as the suspension of a few programs (XMT-1522, ADCT-502) with the overall effect of dampening the impetus of this concept and halting/delaying the progress of drugs associated with it, particularly when immunotherapy is at the center of so many efforts. Numerous antibody-drug conjugates remain, however, in development, and could prove successful. Critically, ADCs could permit the introduction of novel concepts such as the expansion of potent anti-HER2 therapy to HER2-low breast cancer, treatment beyond resistance to T-DM1, and synergy in combination with immune checkpoint blockade. In the early setting, the ATEMPT trial may show that T-DM1 reduces toxicity while maintaining good outcomes for lower risk HER2+ patients. ADCs based on bispecific antibodies are also in development. Finally, breakthroughs are occurring in the orphan triple-negative breast cancer subtype with agents targeting surface proteins. The recent results of Sacituzumab govitecan suggest substantial activity in heavily pre-treated patients and underscore the enduring relevance of antibody drug conjugates as a path towards better outcomes.
    84 schema:genre research_article
    85 schema:inLanguage en
    86 schema:isAccessibleForFree false
    87 schema:isPartOf N43cde78f9a304271929cf1439ac4f7e7
    88 N927130354ed34fb6a42b310562ea4a53
    89 sg:journal.1022080
    90 schema:name Antibody-Drug Conjugates in Breast Cancer: a Comprehensive Review
    91 schema:pagination 37
    92 schema:productId N0e1c0541c6da4074beb63fe78c45330a
    93 N520d977078ba48e0a6d42dab0e67118c
    94 N5560ffbd20ec49ada1f48aba0ef99658
    95 Na0a6731f1ffa41729a071e945a539838
    96 Nb6c325cc34b847dba4bdad5f28798ca0
    97 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113162616
    98 https://doi.org/10.1007/s11864-019-0633-6
    99 schema:sdDatePublished 2019-04-11T14:16
    100 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    101 schema:sdPublisher N797025816c614cccb7dd55ac4c9a0599
    102 schema:url https://link.springer.com/10.1007%2Fs11864-019-0633-6
    103 sgo:license sg:explorer/license/
    104 sgo:sdDataset articles
    105 rdf:type schema:ScholarlyArticle
    106 N04e28013311d4df7b57fad9d6f513eba schema:affiliation Nf232609b0aa64cd6b0683a6dbe1c64db
    107 schema:familyName Piccart
    108 schema:givenName Martine
    109 rdf:type schema:Person
    110 N0e1c0541c6da4074beb63fe78c45330a schema:name dimensions_id
    111 schema:value pub.1113162616
    112 rdf:type schema:PropertyValue
    113 N1ef40a03c03540b593a4b5779f4cd7eb schema:name Department of Research, Institut Jules Bordet; Université Libre de Bruxelles, Boulevard de Waterloo, 121 1000, Brussels, Belgium
    114 rdf:type schema:Organization
    115 N3bc408f506494238a88aecb8365f8436 schema:affiliation https://www.grid.ac/institutes/grid.413320.7
    116 schema:familyName Pondé
    117 schema:givenName Noam
    118 rdf:type schema:Person
    119 N43cde78f9a304271929cf1439ac4f7e7 schema:volumeNumber 20
    120 rdf:type schema:PublicationVolume
    121 N520d977078ba48e0a6d42dab0e67118c schema:name nlm_unique_id
    122 schema:value 100900946
    123 rdf:type schema:PropertyValue
    124 N5560ffbd20ec49ada1f48aba0ef99658 schema:name doi
    125 schema:value 10.1007/s11864-019-0633-6
    126 rdf:type schema:PropertyValue
    127 N7133a40cfa2f4c219504622e7caa0e68 rdf:first Ndd7f73ea53a94638b03b40ebf2a27e0a
    128 rdf:rest Naabb959dff4848f58fc7c55e4786e95c
    129 N797025816c614cccb7dd55ac4c9a0599 schema:name Springer Nature - SN SciGraph project
    130 rdf:type schema:Organization
    131 N927130354ed34fb6a42b310562ea4a53 schema:issueNumber 5
    132 rdf:type schema:PublicationIssue
    133 Na0a6731f1ffa41729a071e945a539838 schema:name readcube_id
    134 schema:value 491845350ba437046d2648f74d2be6f5b2da57ce24341007b9ab72e6cd20350f
    135 rdf:type schema:PropertyValue
    136 Naabb959dff4848f58fc7c55e4786e95c rdf:first N04e28013311d4df7b57fad9d6f513eba
    137 rdf:rest rdf:nil
    138 Nb6c325cc34b847dba4bdad5f28798ca0 schema:name pubmed_id
    139 schema:value 30931493
    140 rdf:type schema:PropertyValue
    141 Nc7b1fde001d649109831c71ecbbed855 rdf:first N3bc408f506494238a88aecb8365f8436
    142 rdf:rest N7133a40cfa2f4c219504622e7caa0e68
    143 Ndd7f73ea53a94638b03b40ebf2a27e0a schema:affiliation N1ef40a03c03540b593a4b5779f4cd7eb
    144 schema:familyName Aftimos
    145 schema:givenName Philippe
    146 rdf:type schema:Person
    147 Nf232609b0aa64cd6b0683a6dbe1c64db schema:name Department of Research, Institut Jules Bordet; Université Libre de Bruxelles, Boulevard de Waterloo, 121 1000, Brussels, Belgium
    148 rdf:type schema:Organization
    149 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    150 schema:name Medical and Health Sciences
    151 rdf:type schema:DefinedTerm
    152 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    153 schema:name Oncology and Carcinogenesis
    154 rdf:type schema:DefinedTerm
    155 sg:journal.1022080 schema:issn 1527-2729
    156 1534-6277
    157 schema:name Current Treatment Options in Oncology
    158 rdf:type schema:Periodical
    159 sg:pub.10.1007/978-3-319-70197-4_10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100469421
    160 https://doi.org/10.1007/978-3-319-70197-4_10
    161 rdf:type schema:CreativeWork
    162 sg:pub.10.1007/s10549-015-3503-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040244288
    163 https://doi.org/10.1007/s10549-015-3503-3
    164 rdf:type schema:CreativeWork
    165 sg:pub.10.1007/s10585-015-9740-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007579842
    166 https://doi.org/10.1007/s10585-015-9740-3
    167 rdf:type schema:CreativeWork
    168 sg:pub.10.1007/s10637-017-0520-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092192646
    169 https://doi.org/10.1007/s10637-017-0520-6
    170 rdf:type schema:CreativeWork
    171 sg:pub.10.1007/s11095-015-1624-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013990430
    172 https://doi.org/10.1007/s11095-015-1624-3
    173 rdf:type schema:CreativeWork
    174 sg:pub.10.1038/bjc.2017.367 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092352159
    175 https://doi.org/10.1038/bjc.2017.367
    176 rdf:type schema:CreativeWork
    177 sg:pub.10.1038/nrd.2016.268 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084129613
    178 https://doi.org/10.1038/nrd.2016.268
    179 rdf:type schema:CreativeWork
    180 sg:pub.10.1038/onc.2015.8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037965589
    181 https://doi.org/10.1038/onc.2015.8
    182 rdf:type schema:CreativeWork
    183 sg:pub.10.1038/sj.onc.1202526 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001624052
    184 https://doi.org/10.1038/sj.onc.1202526
    185 rdf:type schema:CreativeWork
    186 sg:pub.10.1186/s12885-016-2385-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1020233811
    187 https://doi.org/10.1186/s12885-016-2385-z
    188 rdf:type schema:CreativeWork
    189 sg:pub.10.1208/s12248-014-9710-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024929155
    190 https://doi.org/10.1208/s12248-014-9710-8
    191 rdf:type schema:CreativeWork
    192 sg:pub.10.1208/s12248-017-0113-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086146859
    193 https://doi.org/10.1208/s12248-017-0113-5
    194 rdf:type schema:CreativeWork
    195 sg:pub.10.2119/2007-00040.taylor schema:sameAs https://app.dimensions.ai/details/publication/pub.1068965003
    196 https://doi.org/10.2119/2007-00040.taylor
    197 rdf:type schema:CreativeWork
    198 https://doi.org/10.1002/cncr.28465 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019733278
    199 rdf:type schema:CreativeWork
    200 https://doi.org/10.1002/cncr.30789 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085722415
    201 rdf:type schema:CreativeWork
    202 https://doi.org/10.1002/ijc.29210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018963471
    203 rdf:type schema:CreativeWork
    204 https://doi.org/10.1002/ijc.30276 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009346679
    205 rdf:type schema:CreativeWork
    206 https://doi.org/10.1016/j.ccell.2015.12.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042708318
    207 rdf:type schema:CreativeWork
    208 https://doi.org/10.1016/j.ctrv.2018.04.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103765823
    209 rdf:type schema:CreativeWork
    210 https://doi.org/10.1016/j.molonc.2016.07.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037698101
    211 rdf:type schema:CreativeWork
    212 https://doi.org/10.1016/j.pharmthera.2017.05.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085562865
    213 rdf:type schema:CreativeWork
    214 https://doi.org/10.1016/j.taap.2012.04.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030670713
    215 rdf:type schema:CreativeWork
    216 https://doi.org/10.1016/s0305-7372(78)80014-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020712865
    217 rdf:type schema:CreativeWork
    218 https://doi.org/10.1016/s1470-2045(14)70178-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022501322
    219 rdf:type schema:CreativeWork
    220 https://doi.org/10.1016/s1470-2045(17)30312-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085423138
    221 rdf:type schema:CreativeWork
    222 https://doi.org/10.1016/s1470-2045(17)30313-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085422217
    223 rdf:type schema:CreativeWork
    224 https://doi.org/10.1016/s1470-2045(17)30716-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092997796
    225 rdf:type schema:CreativeWork
    226 https://doi.org/10.1016/s1470-2045(17)30717-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092667029
    227 rdf:type schema:CreativeWork
    228 https://doi.org/10.1016/s1470-2045(18)30812-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1112068666
    229 rdf:type schema:CreativeWork
    230 https://doi.org/10.1021/cb500116c schema:sameAs https://app.dimensions.ai/details/publication/pub.1055226626
    231 rdf:type schema:CreativeWork
    232 https://doi.org/10.1021/jm500766w schema:sameAs https://app.dimensions.ai/details/publication/pub.1026892692
    233 rdf:type schema:CreativeWork
    234 https://doi.org/10.1056/nejmoa1113205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031166230
    235 rdf:type schema:CreativeWork
    236 https://doi.org/10.1056/nejmoa1209124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042743567
    237 rdf:type schema:CreativeWork
    238 https://doi.org/10.1056/nejmoa1413513 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043562849
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.1056/nejmoa1703643 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085866538
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1056/nejmoa1809615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107740741
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1056/nejmoa1814213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112259240
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.1093/annonc/mdu486 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033160518
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.1093/annonc/mdv577 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059394619
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.1093/annonc/mdw424 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059394853
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.1093/annonc/mdx541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091867037
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.1097/00000421-198504000-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033873771
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1101/cshperspect.a009159 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034012783
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1126/science.aar4060 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101698084
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1126/scitranslmed.aac4925 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040733977
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1126/scitranslmed.aag2611 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062689221
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1146/annurev-pharmtox-011112-140226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028992563
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1158/1078-0432.ccr-09-1611 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043201205
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1158/1078-0432.ccr-15-0695 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030606964
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1158/1078-0432.ccr-15-2499 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017320489
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1158/1535-7163.mct-13-0896 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005457467
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1158/1535-7163.mct-14-0881-t schema:sameAs https://app.dimensions.ai/details/publication/pub.1038702474
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1158/1535-7163.mct-15-0188 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023777675
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1158/1538-7445.am2015-ct234 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063265076
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1158/1538-7445.sabcs17-pd3-14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101066253
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1200/jco.2009.26.2071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044811338
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1200/jco.2010.29.5865 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039297182
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1200/jco.2011.40.5902 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039292872
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1200/jco.2012.44.9694 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011125550
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1200/jco.2013.52.5683 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050776713
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1200/jco.2014.32.26_suppl.153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083397480
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1200/jco.2014.56.2959 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046908172
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1200/jco.2016.34.15_suppl.607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106842296
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1200/jco.2016.67.4887 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011138111
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1200/jco.2016.70.8297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084253732
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1200/jco.2017.35.15_suppl.108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106845762
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1200/jco.2017.35.15_suppl.2511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106846154
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1200/jco.2018.36.15_suppl.1004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106714027
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1200/jco.2018.36.15_suppl.1028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106714134
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1200/jco.2018.36.15_suppl.1030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106714137
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1200/jco.2018.36.15_suppl.2546 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106714722
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1200/jco.2018.36.15_suppl.506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106715249
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.18632/oncotarget.25615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105076727
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.2217/fon-2017-0336 schema:sameAs https://app.dimensions.ai/details/publication/pub.1093059121
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.2967/jnumed.115.157941 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013958453
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.3389/fimmu.2015.00501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027056417
    323 rdf:type schema:CreativeWork
    324 https://doi.org/doi: 10.4415/ann_13_02_07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078744301
    325 rdf:type schema:CreativeWork
    326 https://www.grid.ac/institutes/grid.413320.7 schema:alternateName AC Camargo Hospital
    327 schema:name AC Camargo Cancer Center, Medical Oncology Department, Sao Paulo, Brazil
    328 Department of Research, Institut Jules Bordet; Université Libre de Bruxelles, Boulevard de Waterloo, 121 1000, Brussels, Belgium
    329 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...