A meta-analysis of consanguinity and breast cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-11

AUTHORS

John B. Wild, Mei-Ju Hwang, Gabriela Jones

ABSTRACT

BACKGROUND: There have been various publications stating that consanguinity both increases and decreases the risk of breast cancer. AIMS: The objective of this study was to determine the impact of consanguinity upon breast cancer. We conducted a systematic review of the literature and meta-analysis. METHODS: Eligible studies were identified on Medline and EMBASE updated to the 19 of September 2017. Studies with sufficient comparative data were included in a meta-analysis. Analyses were carried out using RevMan software. RESULTS: Three comparative studies with a total of 317 individuals with breast cancer and 1459 controls. Reviewing the literature demonstrated conflicting conclusions of the influence of consanguinity upon breast cancer. The meta-analysis showed that there were no statistically significant associations between consanguinity and breast cancer though there was a trend protection from a history of consanguinity. CONCLUSION: Though there is limited literature published on the effects of parental consanguinity, the available data does not demonstrate that it is a risk factor for breast cancer. More... »

PAGES

895-899

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11845-018-1791-4

DOI

http://dx.doi.org/10.1007/s11845-018-1791-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1101748095

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29574661


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