Les sous-types moléculaires du cancer du sein. Apport des technologies à haut débit View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-10

AUTHORS

F. Reyal, M. -A. Bollet, G. Roubaud, A. Vincent-Salomon, R. -J. Salmon

ABSTRACT

Depuis plus de dix ans, le développement continu de nou velles technologies d’analyse à haut débit offre aux scientifiques la possibilité d’étudier la biologie du vivant en général et des cancers en particulier par des voies aussi différentes que complémentaires. Ainsi, les altérations de la structure de l’ADN (amplification, délétion, gain), les pertes d’hétérozygotie (LOH), les altérations du niveau d’expression des gènes, les altéra tions du contrôle posttranscription nelle des microARN, l’activation des complexes protéiques peuvent être analysées simultanément à l’échelle du génome humain. Nous présentons ici un résumé des découvertes obtenues par l’analyse à haut débit du profil d’expression des cancers du sein, en insistant particulièrement sur l’impact ma jeur de ces travaux sur la connais sance et la prise en charge clinique de ces patientes. Les terabytes de données biologiques accumulées par les scientifiques depuis plus de dix ans ne répondent pas sim plement à une lubie technologique mais sont au contraire des outils déterminants de la dissection moderne de ces tumeurs. L’amélio ration du pronostic des patientes atteintes de cancer du sein passe nécessairement par l’utilisation de ces technologies. More... »

PAGES

12-17

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11834-010-0024-6

DOI

http://dx.doi.org/10.1007/s11834-010-0024-6

DIMENSIONS

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40 schema:description Depuis plus de dix ans, le développement continu de nou velles technologies d’analyse à haut débit offre aux scientifiques la possibilité d’étudier la biologie du vivant en général et des cancers en particulier par des voies aussi différentes que complémentaires. Ainsi, les altérations de la structure de l’ADN (amplification, délétion, gain), les pertes d’hétérozygotie (LOH), les altérations du niveau d’expression des gènes, les altéra tions du contrôle posttranscription nelle des microARN, l’activation des complexes protéiques peuvent être analysées simultanément à l’échelle du génome humain. Nous présentons ici un résumé des découvertes obtenues par l’analyse à haut débit du profil d’expression des cancers du sein, en insistant particulièrement sur l’impact ma jeur de ces travaux sur la connais sance et la prise en charge clinique de ces patientes. Les terabytes de données biologiques accumulées par les scientifiques depuis plus de dix ans ne répondent pas sim plement à une lubie technologique mais sont au contraire des outils déterminants de la dissection moderne de ces tumeurs. L’amélio ration du pronostic des patientes atteintes de cancer du sein passe nécessairement par l’utilisation de ces technologies.
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