Ontology type: schema:ScholarlyArticle
2016-03
AUTHORSSharath Sunkavalli, Basanth Babu Eedara, Karthik Yadav Janga, Ashok Velpula, Raju Jukanti, Suresh Bandari
ABSTRACTLiquid self-nanoemulsifying drug delivery systems (L-SNEDDS) of docetaxel were prepared using varying ratios of Capmul PG 8 NF (oil), Cremophor EL (surfactant) and Transcutol-P (co-surfactant). The optimized L-SNEDDS (L11) was transformed into self-nanoemulsifying powder (SNEP) by physical adsorption on to Neusilin US2 and evaluated for dissolution behavior, in vitro cytotoxicity and in vivo oral bioavailability. Optimized L-SNEDDS (L11) composed of 50% of oil, 41.7% of surfactant and 8.3% co-surfactant produced stable emulsion with smaller globules (43±3 nm). In vitro dissolution studies showed the rapid drug release within 5min (95.42±1%) from SNEPN. In vitro cytotoxicity assessed by the MTT assay using MCF-7 human breast cancer cell lines revealed that L-SNEDDS significantly reduced the IC50 value and was 2.3 times lower than the pure docetaxel. Further, the oral bioavailability studies in male Wistar rats showed higher Cmax values following treatment with SNEPN (0.98±0.13 μg/mL) and L-SNEDDS (1.09±0.06 μg/mL) compared to pure docetaxel (0.37±0.04 μg/mL). More... »
PAGES1115-1124
http://scigraph.springernature.com/pub.10.1007/s11814-015-0205-9
DOIhttp://dx.doi.org/10.1007/s11814-015-0205-9
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1027392161
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0306",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Physical Chemistry (incl. Structural)",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Chemical Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Kakatiya University",
"id": "https://www.grid.ac/institutes/grid.411990.4",
"name": [
"Department of Pharmaceutics, St. Peter\u2019s Institute of Pharmaceutical Sciences, 506001, Vidyanagar, Hanamkonda, Warangal, Telangana State, India"
],
"type": "Organization"
},
"familyName": "Sunkavalli",
"givenName": "Sharath",
"id": "sg:person.01315654035.26",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315654035.26"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Kakatiya University",
"id": "https://www.grid.ac/institutes/grid.411990.4",
"name": [
"Department of Pharmaceutics, St. Peter\u2019s Institute of Pharmaceutical Sciences, 506001, Vidyanagar, Hanamkonda, Warangal, Telangana State, India"
],
"type": "Organization"
},
"familyName": "Eedara",
"givenName": "Basanth Babu",
"id": "sg:person.01314563300.01",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314563300.01"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Kakatiya University",
"id": "https://www.grid.ac/institutes/grid.411990.4",
"name": [
"Department of Pharmaceutics, St. Peter\u2019s Institute of Pharmaceutical Sciences, 506001, Vidyanagar, Hanamkonda, Warangal, Telangana State, India"
],
"type": "Organization"
},
"familyName": "Janga",
"givenName": "Karthik Yadav",
"id": "sg:person.01133312235.69",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133312235.69"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Kakatiya University",
"id": "https://www.grid.ac/institutes/grid.411990.4",
"name": [
"Department of Pharmaceutics, St. Peter\u2019s Institute of Pharmaceutical Sciences, 506001, Vidyanagar, Hanamkonda, Warangal, Telangana State, India"
],
"type": "Organization"
},
"familyName": "Velpula",
"givenName": "Ashok",
"id": "sg:person.01247540635.39",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247540635.39"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Kakatiya University",
"id": "https://www.grid.ac/institutes/grid.411990.4",
"name": [
"Department of Pharmaceutics, St. Peter\u2019s Institute of Pharmaceutical Sciences, 506001, Vidyanagar, Hanamkonda, Warangal, Telangana State, India"
],
"type": "Organization"
},
"familyName": "Jukanti",
"givenName": "Raju",
"id": "sg:person.0725567676.59",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725567676.59"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Kakatiya University",
"id": "https://www.grid.ac/institutes/grid.411990.4",
"name": [
"Department of Pharmaceutics, St. Peter\u2019s Institute of Pharmaceutical Sciences, 506001, Vidyanagar, Hanamkonda, Warangal, Telangana State, India"
],
"type": "Organization"
},
"familyName": "Bandari",
"givenName": "Suresh",
"id": "sg:person.01207730101.26",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207730101.26"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1016/0378-5173(94)90271-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002102447"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0378-5173(94)90271-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002102447"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ijpharm.2004.12.019",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003223414"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2217/nnm.11.7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006420101"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0959-8049(97)00363-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008798612"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3109/03639045.2013.801984",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010601549"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci33435",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010926043"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ijpharm.2007.12.022",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013038249"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0378-5173(02)00544-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015019940"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0378-5173(02)00544-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015019940"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ejpb.2006.10.014",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016279393"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.2165/00003088-199936020-00002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018602733",
"https://doi.org/10.2165/00003088-199936020-00002"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.2165/00003088-199936020-00002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018602733",
"https://doi.org/10.2165/00003088-199936020-00002"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0006-2952(94)90580-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019026436"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0006-2952(94)90580-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019026436"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ijpharm.2011.08.041",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019126966"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0378-5173(94)00222-q",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020243805"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/bmc.457",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020813484"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/1520-6017(200008)89:8<1073::aid-jps12>3.0.co;2-v",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021569600"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.bjc.6602698",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021802614",
"https://doi.org/10.1038/sj.bjc.6602698"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.bjc.6602698",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021802614",
"https://doi.org/10.1038/sj.bjc.6602698"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0169-409x(00)00103-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022127682"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ejpb.2009.06.001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022680444"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1124/jpet.106.101154",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023058607"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ejps.2015.03.024",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029999016"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ijpharm.2014.06.019",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031638944"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0928-0987(00)00167-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031826305"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ijpharm.2007.12.016",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033066430"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11814-012-0133-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033074429",
"https://doi.org/10.1007/s11814-012-0133-x"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ijpharm.2012.05.072",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033427412"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.powtec.2012.01.032",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037253398"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s40005-013-0060-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037818326",
"https://doi.org/10.1007/s40005-013-0060-9"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ijpharm.2007.12.026",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038515955"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jconrel.2008.09.086",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042232077"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ijpharm.2004.07.046",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044004825"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0168-3659(00)00343-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044431010"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jps.20068",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044502040"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0928-0987(03)00174-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045571658"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0928-0987(03)00174-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045571658"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0378-5173(02)00085-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046031530"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ijpharm.2003.12.028",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046786103"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ijpharm.2004.02.033",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049176949"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3109/03639045.2014.900081",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051043968"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.addr.2012.11.005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053213603"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ijpharm.2013.08.008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053432231"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0022-1759(83)90303-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053705634"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0022-1759(83)90303-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053705634"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1077845239",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.1995.13.3.645",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1082550214"
],
"type": "CreativeWork"
}
],
"datePublished": "2016-03",
"datePublishedReg": "2016-03-01",
"description": "Liquid self-nanoemulsifying drug delivery systems (L-SNEDDS) of docetaxel were prepared using varying ratios of Capmul PG 8 NF (oil), Cremophor EL (surfactant) and Transcutol-P (co-surfactant). The optimized L-SNEDDS (L11) was transformed into self-nanoemulsifying powder (SNEP) by physical adsorption on to Neusilin US2 and evaluated for dissolution behavior, in vitro cytotoxicity and in vivo oral bioavailability. Optimized L-SNEDDS (L11) composed of 50% of oil, 41.7% of surfactant and 8.3% co-surfactant produced stable emulsion with smaller globules (43\u00b13 nm). In vitro dissolution studies showed the rapid drug release within 5min (95.42\u00b11%) from SNEPN. In vitro cytotoxicity assessed by the MTT assay using MCF-7 human breast cancer cell lines revealed that L-SNEDDS significantly reduced the IC50 value and was 2.3 times lower than the pure docetaxel. Further, the oral bioavailability studies in male Wistar rats showed higher Cmax values following treatment with SNEPN (0.98\u00b10.13 \u03bcg/mL) and L-SNEDDS (1.09\u00b10.06 \u03bcg/mL) compared to pure docetaxel (0.37\u00b10.04 \u03bcg/mL).",
"genre": "research_article",
"id": "sg:pub.10.1007/s11814-015-0205-9",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1046991",
"issn": [
"0256-1115",
"1975-7220"
],
"name": "Korean Journal of Chemical Engineering",
"type": "Periodical"
},
{
"issueNumber": "3",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "33"
}
],
"name": "Preparation and characterization of docetaxel self-nanoemulsifying powders (SNEPs): A strategy for improved oral delivery",
"pagination": "1115-1124",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"827ccb50e06f103ab4dbe22a06ff73e8d753bfd420824a13cbd8c3458073f24a"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s11814-015-0205-9"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1027392161"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s11814-015-0205-9",
"https://app.dimensions.ai/details/publication/pub.1027392161"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T02:08",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000522.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1007%2Fs11814-015-0205-9"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11814-015-0205-9'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11814-015-0205-9'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11814-015-0205-9'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11814-015-0205-9'
This table displays all metadata directly associated to this object as RDF triples.
225 TRIPLES
21 PREDICATES
69 URIs
19 LITERALS
7 BLANK NODES