Effect of CD4+ T-lymphocyte count on hospital outcome of elective general thoracic surgery patients with human immunodeficiency virus View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-11

AUTHORS

Satoshi Nagasaka, Hirohisa Yazaki, Hideyuki Ito, Shin-ichi Oka, Hiromi Kuwata, Ayako Seike, Shinsuke Kitazawa, Shoji Fukuda, Shigeru Hosaka

ABSTRACT

PURPOSE: Traditionally, the chief surgical indicator for human immunodeficiency virus (HIV)-infected patients was the CD4-positive T-lymphocyte count; however, there is no current consensus. Reports published after 2006 indicated that HIV-infected patients had a higher incidence of postoperative pneumonia and higher 12-month mortality rates. In addition, CD4 counts had no relation to the in-hospital outcome. Therefore, we retrospectively examined all of the previous patients who underwent operations in our department on the basis of these findings. METHODS: Regardless of the initiation of highly active anti-retroviral therapy (HAART), we retrospectively reviewed 10 general thoracic surgeries performed in our department according to the CD4 cell count, HIV-ribonucleic acid (RNA) viral load, time of HAART initiation, operating time, amount of blood, postoperative course, and period of observation. RESULTS: There was no incidence of postoperative pneumonia or wound infection. There were also no complications during the perioperative period. One patient died 7 months after surgery. CONCLUSION: Our retrospective study demonstrates that the indicator for elective general thoracic surgery is not the CD4-positive T-lymphocyte count and that the initiation of HAART may reduce the 12-month mortality rates. In HIV-positive patients, regardless of the CD4-positive T-lymphocyte count, surgeons can operate in the same manner as they would with HIV-negative patients. More... »

PAGES

743-747

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11748-011-0808-y

DOI

http://dx.doi.org/10.1007/s11748-011-0808-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046151513

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22083692


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