The efficacy and safety of high-dose statins in acute phase of ischemic stroke and transient ischemic attack: a systematic review View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-08

AUTHORS

Jing-xue Fang, Er-qiang Wang, Wei Wang, Yang Liu, Gang Cheng

ABSTRACT

Inconsistent findings in the studies have been observed concerning the higher dose of statins use in the acute phase of ischemic stroke and transient ischemic attack (TIA). Therefore, we performed a systematic review to assess this issue. A computerized literature search in PubMed, Cochrane Library databases, and EMBASE for randomized controlled trials (RCTs) was conducted. The efficacy outcome indicators were National Institutes of Health Stroke Scale (NIHSS) score, infarct volume, and recurrence of stroke; the safety outcome indicators were intracranial hemorrhage events, cardiovascular and cerebrovascular events, and all-cause death. Pre-specified subgroup analyses were carried out. A total of seven RCTs with 1089 patients were included. Six studies reported the results of the NHISS score. A great reduction was found in NIHSS score in the statins group, and the difference is statistically significant [mean difference (MD) -1.15, 95% confidence interval (CI) -1.64 to -0.66, P < 0.00001]. However, no significant differences in the effect on recurrence of stroke [odds ratio (OR) 1.05, 95% CI 0.65-1.69, P = 0.85] (available in 3 studies), infarct volume [std. mean difference (SMD) 0.04, 95% CI -0.55 to 0.63, P = 0.89] (available in 2 studies), intracerebral hemorrhage events (OR 3.25, 95% CI 0.34-31.52, P = 0.31) (available in 2 studies), cardiovascular and cerebrovascular events (OR 0.70, 95% CI 0.35-1.43, P = 0.33) (available in 2 studies), and all-cause death (OR 1.18, 95% CI 0.60-2.35, P = 0.63) (available in 2 studies) were found. High-dose statin therapy in the acute phase of ischemic stroke and TIA significantly reduce the NIHSS score and improve short-term functional outcome without increasing related adverse events. More... »

PAGES

679-687

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11739-017-1650-8

DOI

http://dx.doi.org/10.1007/s11739-017-1650-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084032837

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28303440


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hydroxymethylglutaryl-CoA Reductase Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ischemic Attack, Transient", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stroke", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Shenyang Pharmaceutical University", 
          "id": "https://www.grid.ac/institutes/grid.412561.5", 
          "name": [
            "School of Life Sciences and Biopharmaceutis, Shenyang Pharmaceutical University, Shenyang, Liaoning, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fang", 
        "givenName": "Jing-xue", 
        "id": "sg:person.010556241671.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010556241671.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "General Hospital of Shenyang Military Region", 
          "id": "https://www.grid.ac/institutes/grid.415460.2", 
          "name": [
            "Department of Neurology, General Hospital of Shenyang Military Command, Shenyang, Liaoning, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Er-qiang", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shenyang Pharmaceutical University", 
          "id": "https://www.grid.ac/institutes/grid.412561.5", 
          "name": [
            "School of Life Sciences and Biopharmaceutis, Shenyang Pharmaceutical University, Shenyang, Liaoning, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Wei", 
        "id": "sg:person.010307016717.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010307016717.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shenyang Pharmaceutical University", 
          "id": "https://www.grid.ac/institutes/grid.412561.5", 
          "name": [
            "School of Life Sciences and Biopharmaceutis, Shenyang Pharmaceutical University, Shenyang, Liaoning, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Yang", 
        "id": "sg:person.011104377317.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011104377317.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shenyang Pharmaceutical University", 
          "id": "https://www.grid.ac/institutes/grid.412561.5", 
          "name": [
            "School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cheng", 
        "givenName": "Gang", 
        "id": "sg:person.01304754156.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304754156.96"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/s12883-015-0367-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005654890", 
          "https://doi.org/10.1186/s12883-015-0367-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12883-015-0367-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005654890", 
          "https://doi.org/10.1186/s12883-015-0367-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/ane.12540", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008653315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.20.7.864", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009265046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/ijs.12539", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011314942"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/ijs.12539", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011314942"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/md.0000000000003186", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014895863"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/md.0000000000003186", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014895863"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1474-4422(09)70025-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015488699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1468-1331.2007.02015.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016701439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1468-1331.2007.02015.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016701439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.112.655894", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022870007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.112.655894", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022870007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/biof.1157", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023686117"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/str.0000000000000046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024681268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/str.0000000000000046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024681268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.atherosclerosis.2015.08.043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025724123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0111247", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028346197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(10)61350-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028469827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jacc.2006.04.070", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032201986"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.109.557330", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040281586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.109.557330", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040281586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1073858406297121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042349891"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1073858406297121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042349891"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(04)15690-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043217755"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2377-10-47", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045158786", 
          "https://doi.org/10.1186/1471-2377-10-47"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1474-4422(07)70250-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047589057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1747-4949.2011.00653.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047788883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1747-4949.2011.00653.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047788883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1503/cmaj.070675", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048364093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1503/cmaj.070675", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048364093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/wnf.0b013e3182206c2f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052206060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/wnf.0b013e3182206c2f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052206060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/wnf.0b013e3182206c2f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052206060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10557-013-6493-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052982924", 
          "https://doi.org/10.1007/s10557-013-6493-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10557-013-6493-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052982924", 
          "https://doi.org/10.1007/s10557-013-6493-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.b2535", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062802292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.b2535", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062802292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.atv.17.11.3294", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063334562"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0000000000002606", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064353498"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0000000000002606", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064353498"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0000000000002606", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064353498"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.20996/1819-6446-2012-8-1-4-16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068825781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/138161209787315729", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069166836"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5853/jos.2015.01578", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073274752"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5853/jos.2015.17.3.282", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073274768"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077848933", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077904860", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.33588/rn.4811.2009069", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077904860"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-08", 
    "datePublishedReg": "2017-08-01", 
    "description": "Inconsistent findings in the studies have been observed concerning the higher dose of statins use in the acute phase of ischemic stroke and transient ischemic attack (TIA). Therefore, we performed a systematic review to assess this issue. A computerized literature search in PubMed, Cochrane Library databases, and EMBASE for randomized controlled trials (RCTs) was conducted. The efficacy outcome indicators were National Institutes of Health Stroke Scale (NIHSS) score, infarct volume, and recurrence of stroke; the safety outcome indicators were intracranial hemorrhage events, cardiovascular and cerebrovascular events, and all-cause death. Pre-specified subgroup analyses were carried out. A total of seven RCTs with 1089 patients were included. Six studies reported the results of the NHISS score. A great reduction was found in NIHSS score in the statins group, and the difference is statistically significant [mean difference (MD) -1.15, 95% confidence interval (CI) -1.64 to -0.66, P\u00a0<\u00a00.00001]. However, no significant differences in the effect on recurrence of stroke [odds ratio (OR) 1.05, 95% CI 0.65-1.69, P\u00a0=\u00a00.85] (available in 3 studies), infarct volume [std. mean difference (SMD) 0.04, 95% CI -0.55 to 0.63, P\u00a0=\u00a00.89] (available in 2 studies), intracerebral hemorrhage events (OR 3.25, 95% CI 0.34-31.52, P\u00a0=\u00a00.31) (available in 2 studies), cardiovascular and cerebrovascular events (OR 0.70, 95% CI 0.35-1.43, P\u00a0=\u00a00.33) (available in 2 studies), and all-cause death (OR 1.18, 95% CI 0.60-2.35, P\u00a0=\u00a00.63) (available in 2 studies) were found. High-dose statin therapy in the acute phase of ischemic stroke and TIA significantly reduce the NIHSS score and improve short-term functional outcome without increasing related adverse events.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s11739-017-1650-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1295016", 
        "issn": [
          "1828-0447", 
          "1970-9366"
        ], 
        "name": "Internal and Emergency Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "12"
      }
    ], 
    "name": "The efficacy and safety of high-dose statins in acute phase of ischemic stroke and transient ischemic attack: a systematic review", 
    "pagination": "679-687", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "48311f38f8dbc947e242d2a972fb7f7c42857dd4ea456f3a6c685982258b23c1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28303440"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101263418"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11739-017-1650-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1084032837"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11739-017-1650-8", 
      "https://app.dimensions.ai/details/publication/pub.1084032837"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:57", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000347_0000000347/records_89807_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs11739-017-1650-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11739-017-1650-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11739-017-1650-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11739-017-1650-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11739-017-1650-8'


 

This table displays all metadata directly associated to this object as RDF triples.

216 TRIPLES      21 PREDICATES      66 URIs      25 LITERALS      13 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11739-017-1650-8 schema:about N0cc0f48e35be470a93b890366b1bbf06
2 Na7ac383f7809489fb4c046d68eb82a58
3 Nd085a8e7bfb548098b19d591cbdf1893
4 Nf6fc5b5599ee49e6a48e2a60a4f7b918
5 anzsrc-for:11
6 anzsrc-for:1102
7 schema:author N8c46c9c5b4ac4f3dbcf453be49e8decc
8 schema:citation sg:pub.10.1007/s10557-013-6493-6
9 sg:pub.10.1186/1471-2377-10-47
10 sg:pub.10.1186/s12883-015-0367-4
11 https://app.dimensions.ai/details/publication/pub.1077848933
12 https://app.dimensions.ai/details/publication/pub.1077904860
13 https://doi.org/10.1002/biof.1157
14 https://doi.org/10.1016/j.atherosclerosis.2015.08.043
15 https://doi.org/10.1016/j.jacc.2006.04.070
16 https://doi.org/10.1016/s0140-6736(04)15690-0
17 https://doi.org/10.1016/s0140-6736(10)61350-5
18 https://doi.org/10.1016/s1474-4422(07)70250-8
19 https://doi.org/10.1016/s1474-4422(09)70025-0
20 https://doi.org/10.1097/md.0000000000003186
21 https://doi.org/10.1097/wnf.0b013e3182206c2f
22 https://doi.org/10.1111/ane.12540
23 https://doi.org/10.1111/ijs.12539
24 https://doi.org/10.1111/j.1468-1331.2007.02015.x
25 https://doi.org/10.1111/j.1747-4949.2011.00653.x
26 https://doi.org/10.1136/bmj.b2535
27 https://doi.org/10.1161/01.atv.17.11.3294
28 https://doi.org/10.1161/01.str.20.7.864
29 https://doi.org/10.1161/str.0000000000000046
30 https://doi.org/10.1161/strokeaha.109.557330
31 https://doi.org/10.1161/strokeaha.112.655894
32 https://doi.org/10.1177/1073858406297121
33 https://doi.org/10.1212/wnl.0000000000002606
34 https://doi.org/10.1371/journal.pone.0111247
35 https://doi.org/10.1503/cmaj.070675
36 https://doi.org/10.20996/1819-6446-2012-8-1-4-16
37 https://doi.org/10.2174/138161209787315729
38 https://doi.org/10.33588/rn.4811.2009069
39 https://doi.org/10.5853/jos.2015.01578
40 https://doi.org/10.5853/jos.2015.17.3.282
41 schema:datePublished 2017-08
42 schema:datePublishedReg 2017-08-01
43 schema:description Inconsistent findings in the studies have been observed concerning the higher dose of statins use in the acute phase of ischemic stroke and transient ischemic attack (TIA). Therefore, we performed a systematic review to assess this issue. A computerized literature search in PubMed, Cochrane Library databases, and EMBASE for randomized controlled trials (RCTs) was conducted. The efficacy outcome indicators were National Institutes of Health Stroke Scale (NIHSS) score, infarct volume, and recurrence of stroke; the safety outcome indicators were intracranial hemorrhage events, cardiovascular and cerebrovascular events, and all-cause death. Pre-specified subgroup analyses were carried out. A total of seven RCTs with 1089 patients were included. Six studies reported the results of the NHISS score. A great reduction was found in NIHSS score in the statins group, and the difference is statistically significant [mean difference (MD) -1.15, 95% confidence interval (CI) -1.64 to -0.66, P < 0.00001]. However, no significant differences in the effect on recurrence of stroke [odds ratio (OR) 1.05, 95% CI 0.65-1.69, P = 0.85] (available in 3 studies), infarct volume [std. mean difference (SMD) 0.04, 95% CI -0.55 to 0.63, P = 0.89] (available in 2 studies), intracerebral hemorrhage events (OR 3.25, 95% CI 0.34-31.52, P = 0.31) (available in 2 studies), cardiovascular and cerebrovascular events (OR 0.70, 95% CI 0.35-1.43, P = 0.33) (available in 2 studies), and all-cause death (OR 1.18, 95% CI 0.60-2.35, P = 0.63) (available in 2 studies) were found. High-dose statin therapy in the acute phase of ischemic stroke and TIA significantly reduce the NIHSS score and improve short-term functional outcome without increasing related adverse events.
44 schema:genre research_article
45 schema:inLanguage en
46 schema:isAccessibleForFree false
47 schema:isPartOf Nd2f75d0c27374c9896bb05c60289e524
48 Nff67715b980f4ae7a6263c4d9804f811
49 sg:journal.1295016
50 schema:name The efficacy and safety of high-dose statins in acute phase of ischemic stroke and transient ischemic attack: a systematic review
51 schema:pagination 679-687
52 schema:productId N3f0636b8c35b422dba46c87d677de5bc
53 N7a9762fb16a34e3eb5093b5b36462979
54 N8faa30d7c5934881833eeadf214a0aab
55 Nb6c48e76e9914ab49c229ad78030f7a7
56 Nd12d3c39e90c461d84c9e7f5a3c22db8
57 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084032837
58 https://doi.org/10.1007/s11739-017-1650-8
59 schema:sdDatePublished 2019-04-11T09:57
60 schema:sdLicense https://scigraph.springernature.com/explorer/license/
61 schema:sdPublisher Nad39a6b06e76469db68a21115486112f
62 schema:url https://link.springer.com/10.1007%2Fs11739-017-1650-8
63 sgo:license sg:explorer/license/
64 sgo:sdDataset articles
65 rdf:type schema:ScholarlyArticle
66 N0cc0f48e35be470a93b890366b1bbf06 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
67 schema:name Humans
68 rdf:type schema:DefinedTerm
69 N3224c11236304c02a3950d75182fd617 rdf:first sg:person.01304754156.96
70 rdf:rest rdf:nil
71 N3f0636b8c35b422dba46c87d677de5bc schema:name readcube_id
72 schema:value 48311f38f8dbc947e242d2a972fb7f7c42857dd4ea456f3a6c685982258b23c1
73 rdf:type schema:PropertyValue
74 N47fcbe3960104755a2f2ef65ac819683 schema:affiliation https://www.grid.ac/institutes/grid.415460.2
75 schema:familyName Wang
76 schema:givenName Er-qiang
77 rdf:type schema:Person
78 N54e85b5dcad74c28b0b35247e7036f43 rdf:first N47fcbe3960104755a2f2ef65ac819683
79 rdf:rest N99503a5da1a644df8fc5537db170c35a
80 N7a9762fb16a34e3eb5093b5b36462979 schema:name dimensions_id
81 schema:value pub.1084032837
82 rdf:type schema:PropertyValue
83 N8c46c9c5b4ac4f3dbcf453be49e8decc rdf:first sg:person.010556241671.59
84 rdf:rest N54e85b5dcad74c28b0b35247e7036f43
85 N8faa30d7c5934881833eeadf214a0aab schema:name pubmed_id
86 schema:value 28303440
87 rdf:type schema:PropertyValue
88 N99503a5da1a644df8fc5537db170c35a rdf:first sg:person.010307016717.59
89 rdf:rest Nf1890f8a0d2147f2b43dbe9b0f01019a
90 Na7ac383f7809489fb4c046d68eb82a58 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Hydroxymethylglutaryl-CoA Reductase Inhibitors
92 rdf:type schema:DefinedTerm
93 Nad39a6b06e76469db68a21115486112f schema:name Springer Nature - SN SciGraph project
94 rdf:type schema:Organization
95 Nb6c48e76e9914ab49c229ad78030f7a7 schema:name nlm_unique_id
96 schema:value 101263418
97 rdf:type schema:PropertyValue
98 Nd085a8e7bfb548098b19d591cbdf1893 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Ischemic Attack, Transient
100 rdf:type schema:DefinedTerm
101 Nd12d3c39e90c461d84c9e7f5a3c22db8 schema:name doi
102 schema:value 10.1007/s11739-017-1650-8
103 rdf:type schema:PropertyValue
104 Nd2f75d0c27374c9896bb05c60289e524 schema:issueNumber 5
105 rdf:type schema:PublicationIssue
106 Nf1890f8a0d2147f2b43dbe9b0f01019a rdf:first sg:person.011104377317.84
107 rdf:rest N3224c11236304c02a3950d75182fd617
108 Nf6fc5b5599ee49e6a48e2a60a4f7b918 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Stroke
110 rdf:type schema:DefinedTerm
111 Nff67715b980f4ae7a6263c4d9804f811 schema:volumeNumber 12
112 rdf:type schema:PublicationVolume
113 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
114 schema:name Medical and Health Sciences
115 rdf:type schema:DefinedTerm
116 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
117 schema:name Cardiorespiratory Medicine and Haematology
118 rdf:type schema:DefinedTerm
119 sg:journal.1295016 schema:issn 1828-0447
120 1970-9366
121 schema:name Internal and Emergency Medicine
122 rdf:type schema:Periodical
123 sg:person.010307016717.59 schema:affiliation https://www.grid.ac/institutes/grid.412561.5
124 schema:familyName Wang
125 schema:givenName Wei
126 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010307016717.59
127 rdf:type schema:Person
128 sg:person.010556241671.59 schema:affiliation https://www.grid.ac/institutes/grid.412561.5
129 schema:familyName Fang
130 schema:givenName Jing-xue
131 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010556241671.59
132 rdf:type schema:Person
133 sg:person.011104377317.84 schema:affiliation https://www.grid.ac/institutes/grid.412561.5
134 schema:familyName Liu
135 schema:givenName Yang
136 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011104377317.84
137 rdf:type schema:Person
138 sg:person.01304754156.96 schema:affiliation https://www.grid.ac/institutes/grid.412561.5
139 schema:familyName Cheng
140 schema:givenName Gang
141 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304754156.96
142 rdf:type schema:Person
143 sg:pub.10.1007/s10557-013-6493-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052982924
144 https://doi.org/10.1007/s10557-013-6493-6
145 rdf:type schema:CreativeWork
146 sg:pub.10.1186/1471-2377-10-47 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045158786
147 https://doi.org/10.1186/1471-2377-10-47
148 rdf:type schema:CreativeWork
149 sg:pub.10.1186/s12883-015-0367-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005654890
150 https://doi.org/10.1186/s12883-015-0367-4
151 rdf:type schema:CreativeWork
152 https://app.dimensions.ai/details/publication/pub.1077848933 schema:CreativeWork
153 https://app.dimensions.ai/details/publication/pub.1077904860 schema:CreativeWork
154 https://doi.org/10.1002/biof.1157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023686117
155 rdf:type schema:CreativeWork
156 https://doi.org/10.1016/j.atherosclerosis.2015.08.043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025724123
157 rdf:type schema:CreativeWork
158 https://doi.org/10.1016/j.jacc.2006.04.070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032201986
159 rdf:type schema:CreativeWork
160 https://doi.org/10.1016/s0140-6736(04)15690-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043217755
161 rdf:type schema:CreativeWork
162 https://doi.org/10.1016/s0140-6736(10)61350-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028469827
163 rdf:type schema:CreativeWork
164 https://doi.org/10.1016/s1474-4422(07)70250-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047589057
165 rdf:type schema:CreativeWork
166 https://doi.org/10.1016/s1474-4422(09)70025-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015488699
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1097/md.0000000000003186 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014895863
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1097/wnf.0b013e3182206c2f schema:sameAs https://app.dimensions.ai/details/publication/pub.1052206060
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1111/ane.12540 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008653315
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1111/ijs.12539 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011314942
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1111/j.1468-1331.2007.02015.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016701439
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1111/j.1747-4949.2011.00653.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047788883
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1136/bmj.b2535 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062802292
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1161/01.atv.17.11.3294 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063334562
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1161/01.str.20.7.864 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009265046
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1161/str.0000000000000046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024681268
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1161/strokeaha.109.557330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040281586
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1161/strokeaha.112.655894 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022870007
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1177/1073858406297121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042349891
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1212/wnl.0000000000002606 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064353498
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1371/journal.pone.0111247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028346197
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1503/cmaj.070675 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048364093
199 rdf:type schema:CreativeWork
200 https://doi.org/10.20996/1819-6446-2012-8-1-4-16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068825781
201 rdf:type schema:CreativeWork
202 https://doi.org/10.2174/138161209787315729 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069166836
203 rdf:type schema:CreativeWork
204 https://doi.org/10.33588/rn.4811.2009069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077904860
205 rdf:type schema:CreativeWork
206 https://doi.org/10.5853/jos.2015.01578 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073274752
207 rdf:type schema:CreativeWork
208 https://doi.org/10.5853/jos.2015.17.3.282 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073274768
209 rdf:type schema:CreativeWork
210 https://www.grid.ac/institutes/grid.412561.5 schema:alternateName Shenyang Pharmaceutical University
211 schema:name School of Life Sciences and Biopharmaceutis, Shenyang Pharmaceutical University, Shenyang, Liaoning, China
212 School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning, China
213 rdf:type schema:Organization
214 https://www.grid.ac/institutes/grid.415460.2 schema:alternateName General Hospital of Shenyang Military Region
215 schema:name Department of Neurology, General Hospital of Shenyang Military Command, Shenyang, Liaoning, China
216 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...