Treatment outcome in a cohort of young patients with polycythemia vera View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-10

AUTHORS

Marco Ruggeri, Silvia Finotto, Stefania Fortuna, Francesco Rodeghiero

ABSTRACT

The treatment of polycythemia vera in young adults is challenging, requiring one to run a balance between the increased risk of vascular complications, if left untreated, versus the potential of promoting secondary leukemia/myelodysplasia or cancer, if actively managed with chemotherapy. We report the results of a 20-year retrospective analysis in a cohort of 30 young adults with PV (median age 37 years, range 19-45) treated exclusively with phlebotomy, aspirin and hydroxyurea only in case of vascular complications occurring in the presence of thrombocytosis (platelet count > 600 × 10(9)/L). With this approach, vascular complications were no higher than in other published series, and secondary leukemia/myelodysplasia or cancer was not observed during a follow-up of 14 years. More... »

PAGES

411-413

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11739-010-0429-y

DOI

http://dx.doi.org/10.1007/s11739-010-0429-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000720440

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20607450


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